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1.
Theriogenology ; 142: 1-7, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31557708

RESUMO

This study reports the distribution of sperm morphology defects by breed, age, season and region of 11,387 bulls in 500 herds in Australia and near Pacific Islands during annual BBSE. Bull location was divided into 4 broad climatic regions based upon temperature, vegetation and climatic risk. Taking into account the impact of age, season, region, and breed there were differences between breeds in both percent morphologically normal sperm and in some individual categories of sperm abnormality (P < 0.001). Independent of breed, season and region, proximal droplets were significantly increased in bulls less than 20 months of age. This is the first study to comprehensively collect data from this wide geographical area and compare sperm morphology profiles among the Bos indicus and Bos taurus breeds. The findings of this study will act as a guide for veterinary practitioners and cattle breeders in the proportion of bulls that can be expected to pass the PNS test, by breed, age and region, based on a robust data set.


Assuntos
Envelhecimento , Bovinos/genética , Bovinos/fisiologia , Estações do Ano , Espermatozoides/citologia , Animais , Austrália , Masculino , Contagem de Espermatozoides , Motilidade dos Espermatozoides , Espermatozoides/fisiologia
2.
Ann Endocrinol (Paris) ; 80(1): 38-46, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30243474

RESUMO

The present review focused on the most important effects of leptin on the hypothalamus and on how leptin regulates neuropeptides associated with food intake and GnRH secretion. This review of the literature suggests that a reduction in leptin serum concentrations results from lower body energy reserves or poor energy availability, leading to hypothalamic secretion of neuropeptides such as NPY/AgRP and QRFP to stimulate food intake. Under these negative metabolic conditions, GnRH secretion is reduced, impairing reproductive functions. In contrast, when metabolic status is inversed by an increase in food availability, energy reserves or both, leptin serum concentrations increase to an action threshold reversing the pattern of secretion: i.e., reducing NPY/AgRP and QRFP and increasing POMC and Kisspeptin, and thereby reducing food intake and stimulating GnRH secretion to promote reproductive function.


Assuntos
Ingestão de Alimentos/fisiologia , Hormônio Liberador de Gonadotropina/metabolismo , Leptina/fisiologia , Neuropeptídeos/fisiologia , Proteína Relacionada com Agouti/metabolismo , Animais , Metabolismo Energético/fisiologia , Homeostase/fisiologia , Humanos , Hipotálamo/fisiologia , Kisspeptinas/metabolismo , Leptina/sangue , Neuropeptídeo Y/metabolismo , Pró-Opiomelanocortina/metabolismo , Reprodução/fisiologia
4.
PLoS One ; 10(4): e0125694, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25915506

RESUMO

STUDY OVERVIEW: The incidence of adverse pregnancy outcomes is higher in pregnancies where the fetus is male. Sex specific differences in feto-placental perfusion indices identified by Doppler assessment have recently been associated with placental insufficiency and fetal growth restriction. This study aims to investigate sex specific differences in placental perfusion and to correlate these changes with fetal growth. It represents the largest comprehensive study under field conditions of uterine hemodynamics in a monotocous species, with a similar long gestation period to the human. Primiparous 14 mo heifers in Australia (n=360) and UK (n=180) were either individually or group fed, respectively, diets with differing protein content (18, 14, 10 or 7% crude protein (CP)) from 60 d prior to 98 days post conception (dpc). Fetuses and placentae were excised at 98 dpc (n = 48). Fetal development an median uterine artery blood flow were assessed monthly from 36 dpc until term using B-mode and Doppler ultrasonography. MUA blood flow to the male feto-placental unit increased in early pregnancy associated with increased fetal growth. Protein restriction before and shortly after conception (-60 d up to 23 dpc) increased MUA diameter and indices of velocity during late pregnancy, reduced fetal heart weight in the female fetus and increased heart rate at birth, but decreased systolic blood pressure at six months of age. CONCLUSION AND SIGNIFICANCE: Sex specific differences both in feto-placental Doppler perfusion indices and response of these indices to dietary perturbations were observed. Further, maternal diet affected development of fetal cardiovascular system associated with altered fetal haemodynamics in utero, with such effects having a sex bias. The results from this study provide further insight into the gender specific circulatory differences present in the fetal period and developing cardiovascular system.


Assuntos
Pressão Sanguínea/fisiologia , Proteínas Alimentares/administração & dosagem , Coração/embriologia , Coração/crescimento & desenvolvimento , Artéria Uterina/fisiopatologia , Animais , Austrália , Velocidade do Fluxo Sanguíneo/fisiologia , Bovinos , Circulação Cerebrovascular , Feminino , Desenvolvimento Fetal , Masculino , Placenta/irrigação sanguínea , Placenta/embriologia , Gravidez , Caracteres Sexuais , Reino Unido
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