RESUMO
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.
Assuntos
Bactérias/química , Glicosídeos/isolamento & purificação , Glicosídeos/farmacologia , Resistência a Vancomicina/efeitos dos fármacos , Bactérias/classificação , Bactérias/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Glicosídeos/química , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Espectrofotometria InfravermelhoRESUMO
Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.