RESUMO
The neutral fraction of the hexane extract of the aerial parts of Santolina viscosa afforded eight new longipinene derivatives (1-8), oblongifolidiol (9), and several other known compounds. The structures of 1-8 were established by spectroscopic methods and chemical transformations. The vulgarone A-type structure previously reported for oblongifolidiol has been reassigned as the longipinene derivative 9 using 2D NMR, chemical correlations, and X-ray diffraction.
Assuntos
Plantas Medicinais/química , Sesquiterpenos/química , Espectroscopia de Ressonância Magnética , Marrocos , Sesquiterpenos/isolamento & purificação , Espanha , Espectrofotometria Infravermelho , Difração de Raios XRESUMO
Efficient syntheses of ent-isozonarol (6a), ent-isozonarone (7a) and ent-chromazonarol (8) from (-)-sclareol (12) are described. 6a and 7a show a significative antitumoral activity.
Assuntos
Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Xantenos/síntese química , Xantenos/farmacologia , Animais , Antineoplásicos/química , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Biologia Marinha , Células Tumorais Cultivadas , Xantenos/químicaRESUMO
The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was carried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and antitumoral activity of selected compounds has been tested.
Assuntos
Asteraceae/química , Sesquiterpenos/química , Animais , Anti-Infecciosos/química , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Camundongos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia , Células Tumorais CultivadasRESUMO
Nine analogues of pyrimidine bases have been tested in vitro, using cultures of epimastigote forms of Trypanosoma cruzi: Three of them are inhibitors of the normal development of Trypanosoma cruzi.
Assuntos
Pirimidinas/farmacologia , Tripanossomicidas , Trypanosoma cruzi/efeitos dos fármacos , Animais , Trypanosoma cruzi/crescimento & desenvolvimentoRESUMO
4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). The in vitro testing revealed that the new compounds are weak reactivators of the phosphorylated electrophorus acetylcholinesterase.
