1.
Clin. transl. oncol. (Print)
; 8(4): 242-249, abr. 2006. ilus
Artigo
em En
| IBECS
| ID: ibc-047663
RESUMO
No disponible
Cancer is an epigenetic disease, a combination ofDNA modifications, chromatin organization and variationsin its associated proteins, configure a new entitythat regulates gene function throughout methylation,acetylation and chromatin remodelling. Irregular denovo DNA methylation, mainly promoter hypermethylation,histone deacetylation or methylation areimportant means for the transcriptional repression ofcancer-associated genes. Reverse these epigeneticprocesses restoring normal expression of malignancy-preventing-genes has consequently become a newtherapeutic target in cancer treatment. Aberrant patternsof epigenetic modifications will be, in a near future,crucial parameters in cancer diagnosis, prognosisand therapy