Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats.

Doxorubicin is associated with cardiotoxicity, and physical exercise seeks to minimize the toxic effects of doxorubicin through physiological cardiac remodeling, as well as the reduction of oxidative stress, evidenced by previous studies. This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20-30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumulative dose of 7.50 mg/kg. Our results show an increase in total collagen fibers in the D group (p = 0.01), but no increase in the TD group, in addition to the attenuation of the number of cardiac mast cells in the animals in the TD group (p = 0.05). The animals in the TD group showed maintenance of tolerance to exertion compared to group D. Therefore, running training attenuated the cardiac damage caused by the treatment with doxorubicin, in addition to maintaining the tolerance to exertion in the rats.

Origin and distribution of femoral nerves in swine (Sus scrofa domesticus) fetuses from crosses of Dan Bred and AGPIC-337 lines / Origem e distribuição dos nervos femorais em fetos suínos (Sus scrofa domesticus - linneaus, 1758) do cruzamento das linhagens Dan Bred e AGPIC337

The objective of this work was to assess the origin and distribution of femoral nerves in 30 swine fetuses from crosses of Dan Bred and AGPIC-337 lines. Thirty animals­fifteen males and fifteen females­from the collection of the Faculty of Veterinary Medicine's Animal Anatomy Laboratory of the Federal University of Uberlândia, Uberlândia MG, Brazil, were used. The animals were fixed by injecting a 10% aqueous formaldehyde solution into the descending aorta artery and thoracic, abdominal, pelvic and intramuscular cavities. The specimens were then submerged in a solution with the same concentration. These animals have five to seven lumbar vertebrae. The number of lumbar vertebrae was six in 96.67% and seven in 3.33% of the animals. The femoral nerve originated from the L4 and L5 (66.67%), L5 and L6 (26.67%) and L3 and L4 (6.66%) lumbar vertebrae. It sent branches to the psoas major, psoas minor, iliac, pectineus, and quadriceps femoris muscles in all animals, to the sartorius in 43.33% and to the gracilis in 6.66% of animals. No marked differences were found in the characteristics of origin and distribution of the femoral nerve between the swine fetuses from crosses of Dan Bred and AGPIC-337 lines and the animals described in the literature.

Objetivou-se estudar a origem e distribuição dos nervos femorais em 30 fetos suínos oriundos do cruzamento das linhagens Dan Bred e AGPIC337. Foram utilizados 30 animais, quinze machos e quinze fêmeas, pertencente ao acervo do laboratório de Anatomia Animal da Faculdade de Medicina Veterinária da Universidade Federal de Uberlândia. A fixação dos animais se deu por meio de injeção de solução aquosa de formaldeído a 10% na artéria aorta parte descendente, cavidades torácica, abdominal, pélvica e intramusculares, em seguida, os espécimes foram submersos em solução contendo a mesma concentração. Esses animais possuem cinco a sete vértebras lombares. Em 96,67% dos animais o número de vértebras lombares foi seis e em 3,33% sete. O nervo femoral originou-se de L4 e L5 (66,67%), L5 e L6 (26,67%) e L3 e L4 (6,66%). Emitiu ramos para os músculos psoas maior, psoas menor, ilíaco, pectíneo, quadríceps femoral em 100% dos casos, 43,33% para o sartório e 6,66% para o grácil. Nota-se que não foram observadas diferenças marcantes nas características tanto na origem como na distribuição do nervo femoral entre os fetos de suínos oriundos do cruzamento das linhagens Dan Bred e AGPIC337 e os animais da literatura consultada