Assuntos
Neoplasias Ósseas/secundário , Dermatomiosite/diagnóstico , Glucocorticoides/uso terapêutico , Interferon-alfa/uso terapêutico , Melanoma/patologia , Metilprednisolona/uso terapêutico , Neoplasias Cutâneas/patologia , Dermatomiosite/tratamento farmacológico , Dermatomiosite/patologia , Feminino , Humanos , Interferon alfa-2 , Melanoma/tratamento farmacológico , Pessoa de Meia-Idade , Prognóstico , Proteínas Recombinantes/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Resultado do TratamentoRESUMO
No disponible
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Assuntos
Feminino , Adulto , Humanos , Siringoma/diagnóstico , Neoplasias das Glândulas Sudoríparas/diagnóstico , Diagnóstico DiferencialRESUMO
No disponible
No disponible
Assuntos
Feminino , Idoso , Humanos , Doenças da Unha/diagnóstico , Doenças da Unha/complicações , Linfedema/complicações , Doenças Respiratórias/complicações , Diagnóstico Diferencial , Vitamina E/uso terapêuticoRESUMO
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Assuntos
Masculino , Pessoa de Meia-Idade , Humanos , Hemangiossarcoma/patologia , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Neoplasias Induzidas por Radiação/patologiaRESUMO
Sézary syndrome (SS) is a leukaemic variant of cutaneous T-cell lymphoma (CTCL). We report a patient with SS who developed granulomatous lesions. These lesions broke out during treatment with bexarotene when the disease had appeared to stabilize. After a partial clinical remission the disease showed rapid progression and finally led to the patient's death. This contradicts the initial assessment, which considered the granulomatous inflammation as a good prognostic factor in CTCL.
Assuntos
Antineoplásicos/efeitos adversos , Toxidermias/etiologia , Granuloma/induzido quimicamente , Síndrome de Sézary/tratamento farmacológico , Tetra-Hidronaftalenos/efeitos adversos , Adulto , Bexaroteno , Toxidermias/patologia , Evolução Fatal , Feminino , Granuloma/patologia , HumanosRESUMO
BACKGROUND: Molluscum contagiosum (MC) is a common cutaneous infection, which has been reported in association with cutaneous pseudolymphoma in few cases. METHODS: A 72-year-old woman with a nodule arising on the external canthus was reviewed. The lesion was surgically removed, and the histopathological study demonstrated an epidermal invagination filled by molluscum bodies and a diffuse infiltrate comprising atypical lymphocytes. RESULTS: Immunohistochemical stains disclosed predominance of T cells with positive CD30 labeling. Polymerase chain reaction failed to demonstrate clonal rearrangement of the T-cell receptor. CONCLUSION: After ruling out systemic involvement, the patient was followed up for 2 years with no evidence of recurrence. We report this case to the best of our knowledge and discuss the literature about atypical clinical and histological presentations of MC.
Assuntos
Molusco Contagioso/patologia , Pseudolinfoma/patologia , Dermatopatias/patologia , Idoso , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-1/metabolismo , Molusco Contagioso/complicações , Molusco Contagioso/cirurgia , Pseudolinfoma/complicações , Pseudolinfoma/cirurgia , Pele/patologia , Dermatopatias/complicações , Dermatopatias/cirurgia , Linfócitos T/metabolismo , Linfócitos T/patologia , Resultado do TratamentoRESUMO
Una mujer de 67 años nos consultó por múltiples lesiones asintomáticas purpúricas en superficies anteriores de muslos y abdomen. La analítica descubrió una hipergammaglobulinemia IgG e IgA. La biopsia cutánea mostró púrpura neutrofílica sin vasculitis. El estudio endocrinológico halló tiroiditis de Hashimoto y la exploración oftalmológica, queratoconjuntivitis seca (AU)
Assuntos
Púrpura/história , Tireoidite Autoimune/etiologiaRESUMO
We report two brothers, aged 5 and 2 years, with typical features of congenital erythropoietic porphyria. The elder did not receive medical attention until the age of 2 years, even though his urine had been red almost from birth, and despite severe scarring of the hands and face. The younger brother suffered haemolysis at birth. The uroporphyrinogen III cosynthase (URO IIIS) enzyme activity of red blood cells was 2% and 1.2% in the brothers, and genetic studies showed two different mutations of the URO IIIS gene, C73R and P248Q. The latter is a recently described mutation.
Assuntos
Eritrócitos/enzimologia , Dermatoses da Mão/sangue , Porfiria Eritropoética/sangue , Uroporfirinogênio III Sintetase/sangue , Pré-Escolar , Dermatoses da Mão/genética , Dermatoses da Mão/urina , Humanos , Lactente , Masculino , Mutação de Sentido Incorreto , Porfiria Eritropoética/genética , Porfiria Eritropoética/urina , Uroporfirinogênio III Sintetase/genéticaRESUMO
We treated 105 patients with anogenital warts with cotton swabs soaked in liquid nitrogen. 90.1% of the patients were cured, but recurrences were observed in 19.5%. With this method we obtained better clinical results than those obtained with the cryoprobes system. Good results were obtained when the lesions were accessible for treatment, but neither the time of evolution nor the size influenced the cure.
Assuntos
Condiloma Acuminado/tratamento farmacológico , Neoplasias dos Genitais Femininos/tratamento farmacológico , Neoplasias dos Genitais Masculinos/tratamento farmacológico , Recidiva Local de Neoplasia , Nitrogênio/uso terapêutico , Feminino , Seguimentos , Humanos , MasculinoRESUMO
Fourteen cases of anogenital warts in children are reported. Girls were more frequently affected than boys (9/5). Three children had been infected during birth; two had autoinfection from non-anogenital warts; two girls had apparently been sexually abused. In the remaining 7 cases the origin of the warts was unknown. The authors discuss the epidemiological, therapeutic and social implications of this little known but important paediatric pathology, pointing to the possibility of sexual transmission in cases of "apparently" unknown origin.
