[A case of elderly locally-advanced breast cancer with skin ulcer responding to letrozole].

We report an 84-year-old woman with an ulcerated tumor of her right breast. The histological examination showed invasive ductal carcinoma, ER (allred-score 8), PgR (allred-score 0), and HER2 (0). Computed tomography and bone scintigraphy showed no distant metastases. She was diagnosed with right locally advanced breast cancer (cT4bN2aM0, stageIIIB) and received hormone therapy with letrozole. One year after, the carcinoma was reduced in size and the skin ulcer had disappeared. Two years later, the carcinoma had grown back slightly, but the skin ulcer was still undetectable. Hormone therapy alone was considered useful for treatment of elderly locally advanced breast cancer patients.

[A case of lung cancer with skin metastases responding to erlotinib].

The patient was a 67-year-old female with left lung adenocarcinoma T2N2M1(brain).She received systemic chemothera- py(cisplatin/docetaxel)and stereotactic radiosurgery.She showed a partial response and PET-CT evidenced no new metastasis. So she underwent left pneumonectomy(LtUt S6S8, adenocarcinoma mixed type pT2pN0).One month later, a small nodule appeared on the dorsal surface of her left hand.Excisional biopsy showed adenocarcinoma metastasis of lung cancer. Soon afterward, multiple skin nodules appeared and were diagnosed multiple skin metastases.Erlotinib was administered. After two weeks, skin metastases were reduced significantly, and she was treated with erlotinib on an outpatient basis for 5 months.This is, to our knowledge, the first case in which skin metastases of lung cancer responded to erlotinib.Our experience suggests erlotinib administration at an early treatment has fewer side effects in therapy for metastatic lung cancer.

[A case of simultaneous bilateral metastatic ovarian tumor of colon cancer followed by FOLFOX4 Regimen and oral tegafur/uracil+oral leucovorin after R0 operation].

The patient was a 41-year-old female, who underwent histectomy and sdnexopexy due to perforated ovarian tumor. One month later, she was diagnosed with simultaneous bilateral metastatic ovarian tumor of colon cancer, and right hemicolectomy (D3) was performed. After surgery, the patient was treated with 10 courses of therapy with the FOLFOX4 regimen. No recurrence was recognized, and the patient was treated with 12 courses of therapy with oral tegafur/ uracil (UFT)+oral Leucovorin (LV). The patient evidenced no tumor recurrence 2 years after the initial treatment. We consider oral UFT+oral LV therapy was useful for post FOLFOX4 therapy after R0 surgery.

[Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan].

PURPOSE: Oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin (FOLFOX) has emerged as the treatment of choice for advanced-stage colorectal cancer. Sensory neurotoxicity is its dose-limiting toxicity. We decided to use Gosha-jinki-gan for prevention of oxaliplatin-related neurotoxicity following the report of Fushiki et al. METHODS: The subjects were 14 patients with metastatic colorectal cancer. Oxaliplatin (85 mg/m(2)) was given intravenously as a FOLFOX4 regimen. All 14 patients received Gosha-jinki-gan every day after first oxaliplatin infusion. RESULT: 7 patients had grade 3 toxicity(neutropenia 6, thrombocytopenia 1). Sensory neuropathy occurred in 10 patients (71.4%). There was no neurotoxicity with functional impairment in this study. CONCLUSIONS: Gosha-jinki-gan seems to prevent acute oxaliplatin-induced neurotoxicity.

[A clinical study of hepatic arterial infusion chemotherapy with 5-FU and leucovorin for liver metastases].

We followed patients who underwent hepatic arterial infusion chemotherapy (HAI) with 5-FU and Leucovorin for liver metastases. Since CR (complete response) and PR (partial response) were achieved, this therapy seems to be effective. 5-FU metabolized on its first pass through the liver, and the hepatic extraction with rapid HAI is lower than that with slow HAI. It is suggested that control of extrahepatic lesions thought rapid HAI is useful for life prolongation.