Examining Differences in Recovery Outcomes between Male and Female Hip Fracture Patients: Design and Baseline Results of a Prospective Cohort Study from the Baltimore Hip Studies.

BACKGROUND: Incidence of hip fractures in men is expected to increase, yet little is known about consequences of hip fracture in men compared to women. It is important to investigate differences at time of fracture using the newest technologies and methodology regarding metabolic, physiologic, neuromuscular, functional, and clinical outcomes, with attention to design issues for recruiting frail older adults across numerous settings. OBJECTIVES: To determine whether at least moderately-sized sex differences exist across several key outcomes after a hip fracture. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study (Baltimore Hip Studies 7th cohort [BHS-7]) was designed to include equal numbers of male and female hip fracture patients to assess sex differences across various outcomes post-hip fracture. Participants were recruited from eight hospitals in the Baltimore metropolitan area within 15 days of admission and were assessed at baseline, 2, 6 and 12 months post-admission. MEASUREMENTS: Assessments included questionnaire, functional performance evaluation, cognitive testing, measures of body composition, and phlebotomy. RESULTS: Of 1709 hip fracture patients screened from May 2006 through June 2011, 917 (54%) were eligible and 39% (n=362) provided informed consent. The final analytic sample was 339 (168 men and 171 women). At time of fracture, men were sicker (mean Charlson score= 2.4 vs. 1.6; p<0.001) and had worse cognition (3MS score= 82.3 vs. 86.2; p<0.05), and prior to fracture were less likely to be on bisphosphonates (8% vs. 39%; p<0.001) and less physically active (2426 kilocalories/week vs. 3625; p<0.001). CONCLUSIONS: This paper provides the study design and methodology for recruiting and assessing hip fracture patients and evidence of baseline and pre-injury sex differences which may affect eventual recovery one year later.

Older men who sustain a hip fracture experience greater declines in bone mineral density at the contralateral hip than non-fractured comparators.

Men experience declining bone mineral density (BMD) after hip fracture; however, changes attributable to fracture are unknown. This study evaluated the excess BMD decline attributable to hip fracture among older men. Older men with hip fracture experienced accelerated BMD declines and are at an increased risk of secondary fractures. INTRODUCTION: The objective was to determine whether bone mineral density (BMD) changes in men after hip fracture exceed that expected with aging. METHODS: Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST). BHS-7 recruited older adults (N = 339) hospitalized for hip fracture; assessments occurred within 22 days of admission and at 2, 6, and 12 months follow-up. MOST enrolled age-eligible men (N = 694) from population-based listings; data were collected at a baseline visit and a second visit that occurred between 10 and 31 months later. The combined sample (n = 452) consisted of Caucasian men from BHS-7 (n = 89) and MOST (n = 363) with ≥ 2 dual-energy X-ray absorptiometry scans and overlapping ranges of age, height, and weight. Mixed-effect models estimated rates of BMD change, and generalized linear models evaluated differences in annual bone loss at the total hip and femoral neck between cohorts. RESULTS: Adjusted changes in total hip and femoral neck BMD were - 4.16% (95% CI, - 4.87 to - 3.46%) and - 4.90% (95% CI, - 5.88 to - 3.92%) in BHS-7 participants; - 1.57% (95% CI, - 2.19 to - 0.96%) and - 0.99% (95% CI, - 1.88 to - 0.10%) in MOST participants; and statistically significant (P < 0.001) between-group differences in change were - 2.59% (95% CI, - 3.26 to - 1.91%) and - 3.91% (95% CI, - 4.83 to - 2.98%), respectively. CONCLUSION: Hip fracture in older men is associated with accelerated BMD declines at the non-fractured hip that are greater than those expected during aging, and pharmacological interventions in this population to prevent secondary fractures may be warranted.

The association of waist circumference with walking difficulty among adults with or at risk of knee osteoarthritis: the Osteoarthritis Initiative.

OBJECTIVE: Excess weight is a known risk factor for functional limitation and common in adults with knee osteoarthritis (OA). We asked to what extent high waist circumference was linked with developing difficulty with walking speed and distance over 4 years in adults with or at risk of knee OA. METHOD: Using data from the Osteoarthritis Initiative (OAI), we employed World Health Organization (WHO) categories for Body Mass Index (BMI) and waist circumference (small/medium and large). Difficulty with speed was defined by slow gait: <1.2 m/s during a 20-m walk, and difficulty with distance was defined by an inability to walk 400 m. We calculated risk ratios (RR) to examine the likelihood of developing difficulty with distance and speed using obesity and waist circumference as predictors with RRs adjusted for potential confounders (i.e., age, sex, race, education, physical activity, and OA status). RESULTS: Participants with obesity and large waists were 2.2 times more likely to have difficulty with speed at 4 years compared to healthy weight and small/medium waisted participants (Adjusted RR 2.2 [95% Confidence interval (CI) 1.6, 3.1], P < .0001). Participants with obesity and a large waist circumference had 2.4 times the risk of developing the inability to walk 400 m compared with those with a healthy BMI and small/medium waist circumference (Adjusted RR 0.9 [95% CI 1.6, 3.7], P < .0001). CONCLUSIONS: Waist circumference may be a main risk factor for developing difficulty with speed in adults with or at risk of knee OA.

The immediate effect of dry needling on multifidus muscles' function in healthy individuals.

BACKGROUND: Dry needling of muscles is mainly used for the management of pain in musculoskeletal disorders. Yet, the association between dry needling and motor performance of muscles is still unclear. OBJECTIVE: To investigate the immediate effect of dry needling on lumbar multifidus muscles' function in healthy subjects. METHODS: Twenty-eight volunteers were divided randomly into: study group (13 subjects) and control group (15 subjects) who underwent no intervention. Study group received dry needling to the lumbar multifidus muscles using a deep insertion technique with 4 needles (2 on each side of the spine). The needles were left in situ for 10 minutes. Ultrasound imaging was used to measure multifidus muscles' thickness, pre and post-procedure during rest in a prone position and during contralateral active straight leg extension. RESULTS: Significant difference was found in the percentage of change of muscle activation post needling between groups on the right side at level L4-5. A slight increase in the percentage of muscle activity, post procedure was observed in the dry needling group compared with the control group, although not significant in other segments examined. CONCLUSION: An improvement of back muscle function following dry needling procedure in healthy individuals was found. This implies that dry needling might stimulate motor nerve fibers and as such increase muscle activity.

Older Adults with Chronic Low Back Pain: A Clinical Population Vulnerable to Frailty?

The purpose of this secondary analysis was to explore the differences in proportions of frailty criteria, pre-frailty, and frailty in older adults with and without chronic low back pain (CLBP). Among individuals with CLBP, we also explored whether the proportions of these outcomes differed based on pain intensity status. Using measures to determine weakness, slowness, and exhaustion, we determined that older adults with CLBP had higher proportions of frailty criteria and were more likely to be classified as pre-frail or frail. Older adults with high intensity CLBP had greater proportions of weakness, exhaustion, and pre-frailty/frailty compared to those with low intensity CLBP. These preliminary findings suggest older adults with CLBP may be at a higher risk for frailty than those without pain; pain intensity may be an important factor in assessing risk of frailty in this population.

The use of nonorganic signs and symptoms as a screening tool for return-to-work in patients with acute low back pain.

STUDY DESIGN: A longitudinal cohort study of patients with acute, work-related low back pain undergoing physical therapy treatment. OBJECTIVE: To determine cut-off values maximizing the predictive ability of the nonorganic signs and symptoms in patients with acute, work-related low back pain and to calculate the predictive validity of the signs and symptoms, alone and in combination, using an outcome of return to work within 4 weeks of initiating treatment. SUMMARY OF BACKGROUND DATA: Waddell et al have proposed nonorganic signs and symptoms as screening tools in patients with chronic low back pain for detecting the presence of abnormal illness behavior and identifying patients in need of further evaluation to improve the likelihood of a successful treatment outcome. METHODS: Consecutive patients referred to physical therapy with work-related low back pain of less than 2 weeks' duration were examined for the presence of nonorganic signs and symptoms before initiating physical therapy treatment. The outcome measure used was the ability to return to work without restrictions within 4 weeks of the initial evaluation. RESULTS: Sensitivity, specificity, and likelihood ratios were calculated for all possible cut-off values for the nonorganic signs, symptoms, and the nonorganic index (signs and symptoms). The best cut-off values were two or more signs (negative likelihood ratio = 0.75), three or more symptoms (negative likelihood ratio = 0.62), and an index score of three or more (negative likelihood ratio = 0.59). Area under a receiver operator characteristic curve for the signs, symptoms, and index were 0.60, 0.63, and 0.63, respectively. CONCLUSIONS: Because the nonorganic tests are purported to serve as screening tests, cut-off values were selected that minimized false-negative results. Even with optimal cut-off values, none of the nonorganic tests served as effective screening tools. Other screening tools may prove more effective for the early identification of patients at increased risk for delay in returning to work after an episode of acute low back pain.

Brainstem evoked potentials for scoliosis surgery: a reliable method allowing use of halogenated anesthetic agents.

A predictable and accurate method of monitoring cord function during scoliosis surgery using somatosensory brainstem evoked potentials (SBEP) is described. This method allows the use of halogenated anesthetic agents, which are ideal for neuromuscular patients, but easily disrupt traditional cortical monitoring. Fifty-eight children with idiopathic, neuromuscular, and syndrome related scoliosis were monitored with 51 true negative, one false negative, four true positive and two false positive results. The SBEP method is sensitive and effective for all types of scoliosis surgery, especially neuromuscular scoliosis.

Loss of intraoperative evoked responses during dorsal column surgery associated with isolated postoperative sensory deficit.

Two patients underwent surgery for the removal of dermoid tumors that involved the dorsal aspect of the spinal cord. Both patients were monitored with intraoperative posterior tibial nerve somatosensory evoked potentials (SSEPs). In each case, the surgical procedure was nearly complete when an abrupt and persistent loss of SSEPs occurred. Although minor recovery of waveforms was present by the end of the operation, the SSEP waveforms remained strikingly abnormal. Neither patient had a postoperative motor deficit, although both had evidence of dorsal column dysfunction. These observations suggest that, during dorsal column surgery, even dramatic SSEP loss may not be associated with motor pathway injury, but rather, may correlate better with postoperative dorsal column dysfunction. The possible implications for intraoperative monitoring of SSEPs during dorsal column surgical procedures are discussed.

The auditory brain stem response reliably predicts hearing loss in graduates of a tertiary intensive care nursery.

Babies (N = 642) were tested for auditory disorder, using the auditory brain stem response (ABR), at the time of their discharge from a tertiary intensive care nursery (ICN). Of those with ABR threshold elevation in one or both ears (N = 97), 61% (N = 59) were retested some months later by a battery of audiological tests; 21 (N = 3.3% of the 642) suffered binaural peripheral loss and 11 (1.7%) now wear hearing aids. These new data, when combined with similar data previously reported from the same ICN, yield a sample of 1613 babies examined during a 5.8-year period from which these conclusions emerge: (1) About 16% of our ICN babies leave the hospital with reduced sensitivity in one or both ears; (2) the hearing deficiency is permanent for 8 to 10%; (3) the loss is sensorineural, bilateral, and so severe for about 4% that hearing aids will be required to optimize their language and psychosocial development. Use of the ABR procedure for neonatal hearing testing is the target of several criticisms: it is being applied too early in life; its predictions about permanent hearing loss are unacceptably inaccurate; or/and it is too costly. We discuss these and still other objections that have been raised.

Auditory brainstem response. Sensory assessment by bone conduction masking.

Auditory brainstem response (ABR) thresholds to clicks were determined for 15 normal hearing adults and for four patients with conductive, sensorineural, or mixed hearing losses. Conductive losses were created in five of the normal hearing adult subjects for which threshold assessment was repeated. The response to a click at 5 dB above threshold was masked with a high-pass, bone-conducted noise. For both the patients and the normal subjects, subtracting 15 dB from the amount of noise required to mask this ABR response approximated sensory threshold. Tympanometry was performed on all patients, except one exhibiting unilateral congenital atresia, to confirm middle ear status.