Validez clínica de la histología intraoperatoria en el diagnóstico de la infección protésica / Clinical validity of the intraoperative histology in the diagnosis of prosthetic joint infection

Antecedentes y objetivo: Diferentes autores han puesto de manifiesto la utilidad del análisis histológico en el diagnóstico de la infección protésica; sin embargo, todavía hoy, su validez clínica es motivo de controversia. El objetivo del presente manuscrito es describir y analizar la validez clínica del análisis histológico en el diagnóstico de infección protésica en el paciente sometido a un recambio protésico de cadera o rodilla. Material y métodos: Se presenta un estudio retrospectivo que incluye 133 recambios protésicos de cadera y rodilla realizados en nuestro centro entre 2008 y 2020. Se realizó un análisis estadístico descriptivo, bivariado y se determinó la validez clínica del análisis histológico. Resultados: La validez clínica del análisis histológico ofreció una sensibilidad del 48%, una especificidad del 91%, un valor predictivo positivo del 55% y un valor predictivo negativo del 88%. Conclusiones: La determinación de la validez clínica del análisis histológico pone de manifiesto una especificidad elevada. Dicho análisis supone una herramienta diagnóstica apropiada para detectar pacientes sanos, con ausencia de infección.(AU)

Background and aim: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. Material and methods: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. Outcomes: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. Conclusions: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.(AU)

[Translated article] Clinical validity of the intraoperative histology in the diagnosis of prosthetic joint infection / Validez clínica de la histología intraoperatoria en el diagnóstico de la infección protésica

Background and aim: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. Material and methods: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. Outcomes: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. Conclusions: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.(AU)

Antecedentes y objetivo: Diferentes autores han puesto de manifiesto la utilidad del análisis histológico en el diagnóstico de la infección protésica; sin embargo, todavía hoy, su validez clínica es motivo de controversia. El objetivo del presente manuscrito es describir y analizar la validez clínica del análisis histológico en el diagnóstico de infección protésica en el paciente sometido a un recambio protésico de cadera o rodilla. Material y métodos: Se presenta un estudio retrospectivo que incluye 133 recambios protésicos de cadera y rodilla realizados en nuestro centro entre 2008 y 2020. Se realizó un análisis estadístico descriptivo, bivariado y se determinó la validez clínica del análisis histológico. Resultados: La validez clínica del análisis histológico ofreció una sensibilidad del 48%, una especificidad del 91%, un valor predictivo positivo del 55% y un valor predictivo negativo del 88%. Conclusiones: La determinación de la validez clínica del análisis histológico pone de manifiesto una especificidad elevada. Dicho análisis supone una herramienta diagnóstica apropiada para detectar pacientes sanos, con ausencia de infección.(AU)

Clinical validity of the intraoperative histology in the diagnosis of prosthetic joint infection. / Validez clínica de la histología intraoperatoria en el diagnóstico de la infección protésica.

BACKGROUND AND AIM: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. MATERIAL AND METHODS: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. OUTCOMES: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. CONCLUSIONS: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.

[Translated article] Clinical validity of the intraoperative histology in the diagnosis of prosthetic joint infection.

BACKGROUND AND AIM: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyse the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. MATERIAL AND METHODS: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our centre between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. OUTCOMES: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. CONCLUSIONS: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.