Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database.

PURPOSE: National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS: The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS: A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION: Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis.

Mapeamento do linfonodo sentinela para carcinoma epidermoide de cavidade oral T1 e T2: a eficácia é mesma do melanoma cutâneo / Sentinel lymph node mapping for T1/T2 oral squamous cell carcinoma: does it have the same efficacy as for cutaneous melanoma

Introdução: O mapeamento do linfonodo sentinela (MLNS) é umatécnica valor no estadiamento linfático dos tumores sólidos e setornou padrão no estadiamento do melanoma cutâneo não sendoainda considerado padrão para estadiamento de carcinomas decavidade oral. Objetivo: Estudar o MLNS como procedimentodiagnóstico e de estadiamento e comparar sua acurácia à do MLNSpara o melanoma cutâneo de Cabeça e Pescoço. Método: Foramanalisados 104 MLNS, 32 com carcinoma de cavidade oral T1 ouT2N0 (grupo A) e 72 melanomas cutâneos estadiados T1b ou maise N0 (grupo B). Foram analisados sensibilidade, especificidadevalor preditivo positivo (VPP), valor preditivo negativo (VPN) eacurácia de ambos grupos. Resultados: A idade média do grupoA foi de 62 anos com 25 homens (77%). Para o grupo B, a mesmafoi de 58 anos com 37 homens (51%). Pelo menos um LinfonodoSentinela foi localizado em 31/32 pacientes no grupo A (96,8%)e 70/72 no Grupo B (97,2%). Tivemos 1 resultado falso negativono grupo A com 83% de sensibilidade, 100% de especificidadeVPP de 100% e VPN de 96,1%. A acurácia total foi de 96,7%. Nogrupo B houve 2 falso negativos, 88% de sensibilidade, 100%de especificidade, VPP de 100%, VPN de 96,4% com acuráciade 97,1% nesse grupo. Conclusão: A acurácia do MLNS paraestadiamento de Carcinoma de cavidade oral T1:T2 é comparávelao método de MLNS para o melanoma cutâneo em Cabeça ePescoço. Descritores: carcinoma epidermoide, cavidade oral,Linfonodo Sentinela, Estadiamento Cervical, melanoma cutâneo.