RESUMO
Nineteen patients with skin neoplasms were treated with intralesional recombinant interferon-alpha 2. There were 11 basal cell carcinomas, 3 squamous cell carcinomas, 4 solar keratoses, and 1 keratoacanthoma. Biopsy specimens were taken before and 2 months after treatment in most cases. Lesions were injected three times weekly for 3 weeks (nine total injections) with 0.9 X 10(6) IU (0.3 ml) of interferon-alpha 2 (total dose 8.1 X 10(6) IU). Clinical and histologic examination revealed three squamous cell carcinomas that had cleared. No basal cell carcinomas had resolved but the keratoses were clinically clear and histologically less active. One keratoacanthoma resolved.
Assuntos
Carcinoma/terapia , Interferon Tipo I/uso terapêutico , Neoplasias Cutâneas/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Basocelular/terapia , Carcinoma de Células Escamosas/terapia , Feminino , Humanos , Injeções Subcutâneas , Interferon Tipo I/administração & dosagem , Ceratoacantoma/terapia , Ceratose/terapia , Masculino , Pessoa de Meia-Idade , Dermatoses do Couro Cabeludo/terapiaRESUMO
A double-blind, randomized, placebo-controlled trial was carried out comparing the effects of clobetasol propionate ointment and the ointment base on the inflammation induced by cryotherapy of basal cell carcinomata and warts. A single application of the steroid was shown to be significantly better at reducing erythema, pain and swelling than the ointment base.
Assuntos
Betametasona/análogos & derivados , Clobetasol/análogos & derivados , Criocirurgia/efeitos adversos , Dermatite/prevenção & controle , Adolescente , Adulto , Idoso , Carcinoma Basocelular/cirurgia , Ensaios Clínicos como Assunto , Clobetasol/uso terapêutico , Dermatite/etiologia , Método Duplo-Cego , Eritema/prevenção & controle , Humanos , Pessoa de Meia-Idade , Pomadas , Dermatopatias/cirurgia , Neoplasias Cutâneas/cirurgia , Verrugas/cirurgiaRESUMO
The effect of ultraviolet A phototherapy on uraemic pruritus was investigated in a placebo-controlled trial. Equivalent and significant reduction of itch was noted in both placebo and treatment groups as assessed by analogue scales and interviews. This reduction in itch could have been the result of either a placebo response or a biological effect of blue light.