1.
Bioorg Med Chem Lett
; 20(22): 6379-83, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20934334
RESUMO
A novel series of pyrazole sEH inhibitors is reported. Lead optimization efforts to replace the aniline core are also described. In particular, 2-pyridine, 3-pyridine and pyridazine analogs are potent sEH inhibitors with favorable CYP3A4 inhibitory and microsomal stability profiles.