RESUMO
Se realizó un estudio retrospectivo por medio de IFI, para detectar anticuerpos IgG anti Chlamydia pneumoiae y Mycoplasma pneumoniae, en pacientes seronegativos para hantavirus, con sintomatología de neumonia atípica y distress respiratorio. Chlamydia pneumoniae alcanzó una prevalencia de 8,6 por ciento y M. pneumoniae de 17,1 por ciento en los pacientes estudiados. Se enfatiza la importancia que estos agentes tienen en nuestro medio y la necesidad de contar con técnicas de laboratorio rápida, que permitan un diagnóstico diferencial oportuno entre el síndrome pulmonar por hantavirus y otras patologías que producen cuadros similares, principalmente con neumonía atípica
Assuntos
Humanos , Chlamydophila pneumoniae , Mycoplasma pneumoniae , Síndrome do Desconforto Respiratório do Recém-Nascido , Chlamydophila pneumoniae , Técnica Indireta de Fluorescência para Anticorpo , Orthohantavírus , Mycoplasma pneumoniae , Síndrome do Desconforto Respiratório do Recém-Nascido , Estudos Retrospectivos , Síndrome Pulmonar por Hantavirus/diagnóstico , Síndrome Pulmonar por Hantavirus/etiologiaRESUMO
Serum concentrations of alpha-2-macroglobulin (alpha 2M) were measured in cord blood from neonates born in Alabama, USA and in Guatemala. Results indicate an inverse relationship between cord serum alpha 2M concentrations and birth weight of newborns in both locations. Infants with lower birth weight had higher cord serum alpha 2M concentrations as compared to those with higher birth weight. The results of the present study using cord serum are similar to those in our previous reports indicating an inverse relationship between maternal serum alpha 2M concentrations and birth weight. This distinctive and reproducible association between alpha 2M concentrations and fetal size in maternal as well as cord blood samples warrants further investigations to determine the mechanism of this relationship.
Assuntos
Peso ao Nascer , Recém-Nascido/sangue , alfa-Macroglobulinas/metabolismo , Alabama , Índice de Massa Corporal , Feminino , Sangue Fetal/metabolismo , Idade Gestacional , Guatemala , Humanos , Masculino , Grupos Raciais , Valores de Referência , Fatores SocioeconômicosRESUMO
Maternal serum alpha-2-macroglobulin (alpha 2M) levels were measured at the time of delivery in 244 women in the central highlands of Guatemala. Significantly higher alpha 2M levels were found in thin women and in poor women. In multiple regression analysis controlling for gestational age, race, sex, maternal triceps skinfold thickness and socioeconomic status, high alpha 2M levels were significantly associated with decreased birthweight. These findings agree with those in a predominantly black population in the United States and extend the relationship between alpha 2M and decreased birthweight to a developing country.