[The immune reactivity transfer factor as a modulator of lymphocyte functional activity in rats]. / Faktor perenosu imunnoï reaktyvnosti iak moduliator funktsional'noï aktyvnosti limfotsytiv shchuriv.

The transplantation of the thyroid tissue is one of the perspective methods for rehabilitation of thyroid gland functional disorders that appear due to the influence of insufficient environmental conditions on organism. By means of micromethod of lymphocyte blast transformation reaction on the base of [3H]-thymidine shift the functional activity of the Wistar rat's splenocytes was studied in case of radiation induced hypothyroidism with or without xenotransplantation of newborn pig thyroid gland organ culture. It was found that the level of thyroxine and triiodothyronine significantly decreased in serum of irradiated animals, the lymphocyte proliferation level was also reduced (by means of radioiodine introduction in dose of 8,325 MBk/mmole). Application of thyroid gland tissue xenotransplantate in this model of hypothyroidism helped to achieve the increasing of thyroid hormones levels in serum and rehabilitation of lymphocytes functional activity. The opportunities for correction of immunological disorders with the help of transfer factor of immune reactivity preparates were investigated. Transfer factor--is a low-molecular weight leukocyte extract (J 10 kD) with immunomodulating activities. This preparates activated the proliferation of splenocytes from animals with hypothyroidism and animals with hypothyroidism after xenotransplantation.

[The role of microorganisms of the wound in postop complications]. / Rol' mikroorhanizmiv rany u vynyknenni pisliaoperatsiinykh uskladnen'.

Sensitivity of mostly wide-spread pathogenic microorganisms to modern antibiotics of the wide spectrum of action (Tienam, Mefoxin, Cifran), and to antibiotics, widely applied in everyday clinical practice was studied.

[Mitogenic effects of staphylococcal antigenic substances on irradiated lymphocytes from Wistar rats]. / Mitohenna dia antyhennykh substantsii stafilokoka na limfotsyty oprominenykh shchuriv liniï vistar.

Proliferation activity of lymphocytes from rats was studied using a micromethod of blasttransformation reaction after X-ray irradiation (absorbed doses for animals were 0.5 and 1 Gy). Staphylococcus protein A and peptidoglycan stimulated the proliferation of irradiated lymphocytes. It was assumed that staphylococcus antigen substances held radiation protective effects. Staphylococcus protein A may be used for stabilization of lymphopoesis and functional activity of humoral and cellular immunity in irradiated animals due to T- and B-mitogenic properties.

[DNA synthesis in lymphocytes of irradiated animals as affected by mitogens and Staphylococcal antigens]. / Syntez DNK u limfotsytakh oprominenykh tvaryn pid vplyvom mitoheniv i antyheniv stafilokoka.

Proliferation activity of lymphocytes from rats was studied using micromethod of blast transformation reaction after exposure of X-ray irradiation (absorbed doses for animals are 0.5 and 1 Gr). The reducing of the functional activity of lymphocytes was found. There was difference in lymphocyte response induced by standard mitogens (PHA, ConA, LPS) and antigens of Staphylococcus protein A and peptidoglycan. The irradiation protective effects of Staphylococcus substances were found.

[Human specific transfer factor to Staphylococcus aureus antigens]. / Liuds'kyi spetsyfichnyi Faktor perenosu do antyheniv Staphylococcus aureus.

Immunobiological properties of human specific transfer factor (TF) to Staphylococcus aureus antigens were studied. It is shown that this TF activated human leucocytes in vitro as well as in vivo. Antigen specificity of TF's immunomodulating effects is also shown. In vitro we used leucocyte migration inhibition test (IML), macrophage inhibition test (MPI) and rosette formation (E-ros). For testing in vivo we used delayed type hypersensitivity (DTH) skin tests.

[The biological activity of the transfer factor induced by bacterial antigens]. / Biolohichna aktyvnist' faktora perenosu, indukovanoho bakterial'nymy antyhenamy.

Today's statement of transfer factor, an immunostimulator derived from leukocytes which enhances antiinfectious immunity, is observed in the review. Basic biological, physical and chemical characteristics of the transfer factor, its possible action mechanisms, and laboratory and clinical methods of use to cure infectious fungal (Candida, Coccidium), invasive (schistosomiasis, leishmaniasis, cryptosporidiosis), viral (varicella zoster, ophthalmic herpes, Herpes simplex types 1 and 2, H. zoster, H. simplex ceratitis, genital herpes, human herpes virus type 6, postherpetic neuritis, hepatitis B, AIDS), and bacterial infections (Mycobacterium leprae, M. tuberculosis, M. fortuitum, Salmonella cholerae suis, S. dublin, S. Virchov, Brucella abortus, Actinobacillus pleuropneumoniae, bacterial sepsis, Staphylococcus) are described.