1.
Bioorg Med Chem Lett
; 14(5): 1229-34, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14980671
RESUMO
Using N,N-dialkylated benzamidines as the novel P4 motifs, we have designed and synthesized a class of 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides as highly potent and selective fXa inhibitors with significantly improved hydrophilicity and in vitro anticoagulant activity. These benzamidine-P4 fXa inhibitors have displayed excellent oral bioavailability and long half-life.