RESUMO
Treatment of pi-allyltricarbonyliron lactone complexes, that contain an adjacent leaving group, with lithium naphthalenide causes decomplexation to acyclic dienols in excellent yield and without any stereochemical scrambling of the allylic centre. When an endo complex is employed (E,E)-geometry prevails with good selectivity whereas (Z,E)-geometry dominates in the case of exo complexes. A mechanism consistent with the observed stereo- and regiochemistry is proposed.
Assuntos
Química Orgânica/métodos , Ferro/química , Lactonas/química , Álcoois/química , Carbonatos/química , Lítio/química , Espectroscopia de Ressonância Magnética , Modelos Químicos , Naftalenos/química , EstereoisomerismoRESUMO
Silyl enol ethers derived from ketone functionalised rho-allyltricarbonyliron lactone complexes undergo highly diastereoselective carbon-fluorine and carbon-oxygen bond formation reactions with excellent control at the alpha-stereogenic centre.
Assuntos
Flúor/química , Ferro/química , Carbono/química , Éteres/química , Lactonas/química , Espectroscopia de Ressonância Magnética , Modelos Químicos , Modelos Moleculares , Oxigênio/químicaRESUMO
The synthesis of the germination self-inhibitor (-)-Gloeosporone is reported. The embedded 1,7-diol motif in the product is constructed by an ironcarbonyl tether controlled Mukaiyama aldol reaction. The key step in the synthesis is the reductive removal of the ligating iron species by treatment of an acetoxycomplex 6 with lithium naphthalenide.
Assuntos
Antifúngicos/síntese química , Antifúngicos/farmacologia , Lactonas/química , Lactonas/síntese química , Lactonas/farmacologia , Esporos Fúngicos/efeitos dos fármacos , Antifúngicos/química , Colletotrichum/química , Estrutura Molecular , Esporos Fúngicos/fisiologiaRESUMO
The total synthesis of taurospongin A by two new approaches has been achieved where pi-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.
Assuntos
Alcinos/síntese química , DNA Polimerase beta/antagonistas & inibidores , Inibidores Enzimáticos/síntese química , Ésteres/síntese química , Transcriptase Reversa do HIV/antagonistas & inibidores , Compostos de Ferro/química , Lactonas/química , Alcinos/farmacologia , Inibidores Enzimáticos/farmacologia , Ésteres/farmacologia , Inibidores da Transcriptase Reversa/síntese química , Inibidores da Transcriptase Reversa/farmacologia , EstereoisomerismoRESUMO
Treatment of pi-allyltricarbonyliron lactone complexes bearing an adjacent leaving group, with lithium naphthalenide causes decomplexation to acyclic dienols in excellent yield and without any scrambling of the allylic centre.
RESUMO
The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.