RESUMO
Objective: To explore the influence of angiotensin-(1-7) \[Ang-(1-7)\] and phorbol 12-myristate 13-acetate (PMA)on the proliferation and secretion of cultured rat glomerular mesangial cells (GMC) induced by angiotensinⅡ(AngⅡ). Methods: Ang-(1-7) and PMA was used in cultured rat glomerular mesangial cells induced by AngⅡ, synthesis of DNA and protein, change of cell number were observed for rat GMC proliferation. Secretion of PcⅢ and HA was measured by radioimmunoassay in culture medium of rat GMC. Results: Ang-(1-7) and PMA both inhibited the AngⅡinduced synthesis of DNA and protein, increase of cell number, and secretion of PcⅢ and HA in cultured rat GMC. Conclusion: Ang-(1-7) and PMA both can inhibit the AngⅡ induced proliferation and secretion of cultured rat GMC.
