1.
Bioorg Med Chem Lett
; 21(7): 1978-82, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21377875
RESUMO
In our search for new PPARα/γ agonists, we designed and synthesized a series of benzoylazole-based carboxylic acids. Compound 9 showed potent PPARγ partial agonistic activity with modest PPARα agonistic activity. The sodium salt of 9 (9Na) demonstrated potent efficacy in lowering both blood glucose and lipids in an animal model without causing significant body weight gain, a well-known side effect associated with PPARγ full agonists.