RESUMO
BACKGROUND: Renal biopsy is not free from complications and patients who undergo this procedure are usually hospitalized to receive intensive care for several days after biopsy. In contrast, after this period, routine follow-up to detect biopsy-associated complications is rarely scheduled, unless the patient develops a clinical manifestation. We describe a case of marked enlargement of arteriovenous fistula in the kidney that occurred many years after renal biopsy. In contrast to the previous cases requiring interventional radiology, our patient showed subclinical growth of fistula over about nine years. CASE PRESENTATION: A 24-year-old man with a history of percutaneous renal biopsy was hospitalized for interventional radiology. Gross hematuria emerged shortly after biopsy, but completely disappeared with administration of hemostatic agents and bed rest. Subsequently, the patient had few symptoms for many years. A giant fistula (a gourd-shaped mass, size 26 × 22 and 12 × 11 mm) was unexpectedly detected by ultrasonography performed for examination of an unrelated disorder (slight elevation of serum transaminase) at 9 years after the original biopsy. The fistula was successfully treated with radiological intervention. Thus, subclinical development of complications associated with renal biopsy should be considered, even in an uneventful course. CONCLUSIONS: This case provides a platform to discuss the importance of long-term follow-up of patients after renal biopsy despite of its difficulty.
Assuntos
Fístula Arteriovenosa/diagnóstico por imagem , Fístula Arteriovenosa/etiologia , Biópsia por Agulha/efeitos adversos , Rim/patologia , Humanos , Rim/irrigação sanguínea , Masculino , Artéria Renal/diagnóstico por imagem , Adulto JovemRESUMO
We describe a 19-year-old male who developed diclofenac-induced acute interstitial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and promptly recovered after initiation of low-dose prednisolone (0.5 mg/kg/day). There are no established criteria for the administration of corticosteroids in the treatment of drug-induced AIN. Moreover, no clear recommendations regarding the optimal dose and duration of steroid administration in the treatment for drug-induced AIN has been established. In addition, we discuss the clinical benefit of steroid treatment and the diagnostic impact of Ga scanning on the management of drug-induced AIN.
Assuntos
Corticosteroides/administração & dosagem , Radioisótopos de Gálio , Rim/efeitos dos fármacos , Rim/diagnóstico por imagem , Nefrite Intersticial/diagnóstico por imagem , Nefrite Intersticial/tratamento farmacológico , Compostos Radiofarmacêuticos , Doença Aguda , Anti-Inflamatórios não Esteroides/efeitos adversos , Biópsia , Diclofenaco/efeitos adversos , Humanos , Rim/patologia , Rim/fisiopatologia , Masculino , Nefrite Intersticial/induzido quimicamente , Nefrite Intersticial/patologia , Nefrite Intersticial/fisiopatologia , Valor Preditivo dos Testes , Cintilografia , Resultado do Tratamento , Adulto JovemAssuntos
Supressores da Gota/uso terapêutico , Hiperuricemia/tratamento farmacológico , Diálise Renal , Tiazóis/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Monitoramento de Medicamentos , Febuxostat , Supressores da Gota/sangue , Humanos , Hiperuricemia/sangue , Hiperuricemia/diagnóstico , Masculino , Pessoa de Meia-Idade , Tiazóis/sangue , Fatores de Tempo , Resultado do Tratamento , Ácido Úrico/sangueRESUMO
A 56-year-old male with chronic renal failure was admitted to the hospital because of progressive hip pain, appetite loss, general fatigue, and hypercalcemia. Slight pain had developed in the left hip 3 months before the initiation of hemodialysis, which subsequently developed into hyperalgesia. The patient was suspected to have sarcoidosis based on the elevated serum angiotensin-converting enzyme and lysozyme levels, and the ocular finding characterized by punched out chorioretinal scarring, although this could not be confirmed by histological evaluations. There was an abnormal uptake of gallium in the dependent portion of the tumoral calcinosis, which could have suggested either the presence of granulomatous sarcoid tissue within the calcified mass or active calcification associated with an inflammatory reaction. Elevated serum concentrations of 1,25-dihydroxyvitamin D3, which should be implicated in the development of hypercalcemia, promptly decreased after the administration of steroids. Steroid administration subsequently led to a decrease in the serum calcium and relief of the hip pain. This was a rare case of sarcoidosis associated with symptomatic tumoral calcinosis and hypercalcemia. The diagnostic significance of a gallium scan in this case will also be discussed.
Assuntos
Calcinose/etiologia , Calcinose/patologia , Hipercalcemia/complicações , Hipercalcemia/etiologia , Falência Renal Crônica/complicações , Sarcoidose/etiologia , Calcinose/sangue , Calcitriol/sangue , Gálio , Humanos , Hipercalcemia/sangue , Falência Renal Crônica/sangue , Falência Renal Crônica/patologia , Masculino , Pessoa de Meia-Idade , Peptidil Dipeptidase A/sangue , Diálise Renal/métodos , Sarcoidose/sangue , Sarcoidose/patologia , Tomografia Computadorizada de EmissãoRESUMO
Assessment of airborne organophosphorus pesticides in houses of young children (1-6 years old) and childcare facilities was conducted following pesticide applications in an agricultural community in Japan. Trichlorfon and fenitrothion, applied in two separate periods, were frequently detected from outdoor and indoor air. Dichlorvos, the primary degradation product of trichlorfon, was also detected after the application of trichlorfon. Both the outdoors and indoor concentration of applied pesticide were shown to increase with decreasing distance from the pesticide-applied farm. Indoor concentration of these pesticides significantly correlated with outdoor concentration (p=0.001 for trichlorfon and p=0.001 for fenitrothion), indicating infiltration of applied pesticide inside. Ratio of indoor to outdoor concentration (I/O ratio) of fenitrothion was higher for houses with windows open during the application than those with closed windows (median value: 0.74 vs. 0.16, p=0.003). However, a similar trend was not observed for trichlorfon as well as dichlorvos in the first period. Dichlorvos was found to have a higher I/O ratio than trichlorfon during the period, and clear correlation between indoor concentrations of dichlorvos and those of trichlorfon suggested increased decomposition of trichlorfon in the indoor environment. Daily inhalation exposure estimated by using the fixed measurement data and time-activity questionnaire ranged from 0 to 35 ng/kg/day for trichlorfon, from 0 to 26 ng/kg/day for dichlorvos, and from 0 to 44 ng/kg/day for fenitrothion. Median inhalation exposure from indoor air accounted for 74%, 86.3%, and 45% of the daily inhalation exposure, respectively. For kindergarteners or nursery school children, inhalation exposure at childcare facilities was comparable with or more than that at home, indicating that pollution level at childcare facilities had potential of high impact on children's exposure. Estimated daily inhalation exposures were inversely correlated to the proximity of their activity location to the pesticide-applied farm.