Long-lasting canine cardiovascular alterations following bromocriptine induced-estrus.

Bromocriptine (BRM), a dopamine 2 receptor agonist, is a common drug for inducing estrus in dogs. It is also used for the treatment of some endocrine abnormalities and has some cardiovascular consequences in the patients under treatment. The current study aimed to evaluate its effects on the cardiovascular function of dogs during administration and the subsequent induced estrus cycle. Eight non-pregnant female dogs were assigned into control and treatment groups. The control group (n = 3) were dogs that showed proestrus naturally. The treatment group (n = 5) received oral incremental (µg/kg) doses (100 on days 1 and 2, 200 on days 3, 4, and 400 on days 5 until the proestrus expression) of BRM tablets (2.5 mg; Iran-Hormone Co, Iran). The left ventricle function, carotid blood flow indices, and systolic (SAP) and diastolic (DAP) arterial pressure were recorded every two days. The phases of the cycle were determined using a vaginal smear. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI) had a sharp decline following the administration of BRM (P < 0.05). The carotid PSA, EDV, RI, and pulse index were lower during induced estrus compared to the control (p < 0.05). BRM-induced estrus showed a different pattern of changes compared to the normal cycle from day 9 (p < 0.05) onwards. The cardiovascular effects of BRM remained for days after the termination of administration which may interfere with reproductive functions.

Ultrasound monitoring of pregnancy in mini-lop rabbits.

Ultrasound plays a considerable role in human and animal reproduction in terms of early detection of pregnancy, prediction of parturition time, and diagnosis of fetal abnormalities. The present study aimed to evaluate the ultrasound implementation for monitoring of gestation in mini-lop rabbits. Fifteen heads of pubertal does were selected and kept in normal conditions of feeding and temperature. Animals were mated with three bucks from the same breed. The pregnancy monitoring was begun from five days post-mating (dpm) to kindling using a 12.5 MHz ultrasonic transducer. The examinations were performed at fixed dpm for all does (5, 7, 12, 16, 20, and 26). Furthermore, randomly selected does (2-3 does per day; one doe was fixed) were subjected to daily ultrasound examination to estimate the relationship between the ultrasound biometrics with the gestational age (GA) and days to parturition. The pregnancy rate was 80%, and the mean number of live kits at birth was 4.2 in the present study. Based on the ultrasound records, the gestation length can be divided into three tertiles of pregnancy (TOP) in rabbits. The first TOP (0-10 dpm) was monitored by detecting and measuring the gestational sac diameter from 6 to 10 dpm. The 2nd TOP (11-12 dpm) was characterized by detection and measurement of Crown Rump Length and Fetal Heart Rate. From 15 to 20 dpm, bi-parietal diameter and head circumference were positively correlated with the GA (p-value < 0.05). Abdominal circumference and femur length were detectable and measurable during the 3rd TOP (21 dpm-kindling). Pregnancy was detected as early as six dpm with acceptable markers in mini-lop rabbits. Highly significant negative correlations were detected between days to parturition and the sonographic biometrics. Three abnormal fetuses were successfully detected and described, too.

Patent ductus arteriosus in a lamb: A case report.

Patent ductus arteriosus (PDA) is a persistent patency of a vessel normally present in the fetus that connects the pulmonary arterial system to the aorta. The ductus arteriosus fails to close at birth when breathing commences and placental blood circulation is removed. Closure of the ductus arteriosus arises in response to decline pulmonary vascular resistance and increased systemic vascular resistance. This report describes a case of PDA in a two-month-old male lamb with clinical signs of machinery murmur, tachycardia, increase respiratory rate, weakness and ill thrift. Echocardiographic examination and necropsy finding confirmed PDA.