Sodium arsenite induces hepatic stellate cells activation by m6A modification of TGF-ß1 during liver fibrosis.

The compound known as Sodium arsenite (NaAsO2), which is a prevalent type of inorganic arsenic found in the environment, has been strongly associated with liver fibrosis (LF), a key characteristic of nonalcoholic fatty liver disease (NAFLD), which has been demonstrated in our previous study. Our previous research has shown that exposure to NaAsO2 triggers the activation of hepatic stellate cells (HSCs), a crucial event in the development of LF. However, the molecular mechanism is still unknown. N6-methyladenosine (m6A) modification is the most crucial post-transcriptional modification in liver disease. Nevertheless, the precise function of m6A alteration in triggering HSCs and initiating LF caused by NaAsO2 remains unknown. Here, we found that NaAsO2 induced LF and HSCs activation through TGF-ß/Smad signaling, which could be reversed by TGF-ß1 knockdown. Furthermore, NaAsO2 treatment enhanced the m6A modification level both in vivo and in vitro. Significantly, NaAsO2 promoted the specific interaction of METTL14 and IGF2BP2 with TGF-ß1 and enhanced the TGF-ß1 mRNA stability. Notably, NaAsO2-induced TGF-ß/Smad pathway and HSC-t6 cells activation might be avoided by limiting METTL14/IGF2BP2-mediated m6A modification. Our findings showed that the NaAsO2-induced activation of HSCs and LF is made possible by the METTL14/IGF2BP2-mediated m6A methylation of TGF-ß1, which may open up new therapeutic options for LF brought on by environmental hazards.

QTc prolongation after aneurysmal subarachnoid hemorrhage might be associated with worse neurologic outcome in patients receiving microsurgical clipping or embolization of the intracranial aneurysms: a retrospective observational study.

PURPOSE: QT interval prolongation is one of the most common electrocardiographic (ECG) abnormalities in patients with aneurysmal subarachnoid hemorrhage (aSAH). Whether corrected QT interval (QTc) prolongation is associated with perioperative cardiac events and dismal neurological outcome in mid to long-term follow-up in patients after aSAH is insufficiently studied and remains controversial. METHODS: We retrospectively studied the adult (≥ 18 years) patients admitted to our institution between Jan 2018 and Dec 2020 for aSAH who underwent intracranial aneurysm clipping or embolization. The patients were divided into 2 groups (normal and QTc prolongation groups) according to their QTc. To minimize the confounding bias, a propensity score matching (PSM) analysis was performed to compare the neurologic outcomes between patients with normal QTc and QTc prolongation. RESULTS: After screening, 908 patients were finally included. The patients were divided into 2 groups: normal QTc groups (n = 714) and long QTc group (n = 194). Female sex, hypokalemia, posterior circulation aneurysm, and higher Hunt-Hess grade were associated with QTc prolongation. In multiple regression analysis, older age, higher hemoglobin level, posterior circulation aneurysm, and higher Hunt-Hess grade were identified to be associated with worse outcome during 1-year follow-up. Before PSM, patients with QTc prolongation had higher rate of perioperative cardiac arrest or ventricular arrhythmias. After PSM, there was no statistical difference between normal and QTc prolongation groups in perioperative cardiac events. However, patients in the QTc prolongation group still had worse neurologic outcome during 1-year follow-up. CONCLUSIONS: QTc prolongation is associated with worse outcome in patients following SAH, which is independent of perioperative cardiac events.

EGCG induces degradation of active folate in serum via H2O2 generation, while L-ascorbic acid effectively reverses this effect.

Empirical studies have indicated that excessive tea consumption may potentially decrease folate levels within the human body. The main active component in green tea, epigallocatechin gallate (EGCG), significantly reduces the concentration of 5-methyltetrahydrofolate (5-MTHF) in both solution and serum. However, our findings also demonstrate that the pro-degradation effect of EGCG on 5-MTHF can be reversed by L-ascorbic acid (AA). Subsequent investigations suggest that EGCG could potentially expedite the degradation of 5-MTHF by generating hydrogen peroxide. In summary, excessive tea intake may lead to reduced folate levels in the bloodstream, yet timely supplementation of AA could potentially safeguard folate from degradation.

Endoscopic Balloon Dilatation of the Eustachian Tube via the Soft Palate Approach in Miniature Pigs.

The eustachian tube (ET) is one of the most complex organs in the human body, and its dysfunction may lead to a variety of diseases. In recent years, an increasing number of scholars have opted to conduct ET-related studies using large experimental animals such as miniature pigs or sheep, yielding promising results. Typically, conventional endoscopic procedures are performed through the nasal approach for large experimental animals. However, due to the elongated and narrow nasal cavity in these animals, transnasal surgeries are challenging. To address this issue, we explored an ET surgery approach via the soft palate. The animal was placed in a supine position. After endotracheal intubation under general anesthesia, a mouth opener was used to fully expose the upper palate. Local infiltration with diluted adrenal fluid was performed for anesthesia of the area. A sickle knife was then used to make a longitudinal soft palate incision at the junction of the soft and hard palates. After hemostasis, an endoscope was inserted into the nasopharynx cavity, allowing the visualization of the pharyngeal opening of the ET on the posterior lateral wall of the nasal cavity. Subsequently, a specialized pusher was used to insert a balloon into ET. The balloon was inflated, maintained at 10 bar for 2 min, and then removed. The incision in the soft palate was then sutured to ensure proper alignment. The soft palate healed well after the operation. This surgical approach is suitable for ET-related procedures in large experimental animals (e.g., miniature pigs, sheep, and dogs). The surgical procedure is simple, with a short surgical time, and wound healing is rapid. Under endoscopy, the pharyngeal opening of the ET is visible, and it is thus a good choice for procedures such as balloon dilation of the ET.

The Influence of Physical Exercise on College Students’ Mental Health from The Perspective of Political Education / La influencia del ejercicio físico en la salud mental de los estudiantes universitarios desde la perspectiva de la educación política

This study examines the impact of parental support and course teachers on students' physical exercise behavior. It aims to provide insights for improving the physical education curriculum and enhancing its effectiveness. The purpose of using a Political education perspective in guiding physical education in colleges and universities is to assess the influence of physical education on college students' mental health and provide relevant information for physical education programs in these institutions. A random sampling method was used to survey 1000 college students in A City. The mental health of college students was assessed using the List 90 (SCL-90) developed by L.R. Derogatis, and their physical performance was evaluated using the Physical Performance Test (par-3) conducted by Liang Deqing and colleagues. The results were analysed. Statistically significant differences were found between the experimental and control groups in compulsion, interpersonal relationships, depression, hostility, fear, disorder, and emotion. Physical exercise showed a strong correlation of 91.7% with college students' mental health. By analysing the disparities, it is evident that various forms of physical education exert distinct impacts on mental well-being. The Political education perspective positively influences the guidance of college students' physical exercise. Regular physical exercise significantly benefits the overall health of college students, with a notable emphasis on its positive impact on their mental well-being. Firstly, broaden the scope of the study population and enhance the diversity of the research sample. While there is a substantial body of research on exercise behaviour among college students and adults, there is a scarcity of studies focusing on exercise behaviour among middle school children, particularly in the middle school age group. This study will contribute to the research field of exercise behaviour and expand the research group's scope. Secondly, interdisciplinary research. Physical exercise behaviour is a concern in both physical education and sociology. Children's mental health issues involve multiple disciplines, including psychology, sociology, economics, and demographics. Combining the two requires interdisciplinary knowledge to explain mechanisms and influencing factors comprehensively and reasonably.(AU)

Ambient temperatures associated with reduced cognitive function in older adults in China.

The cognitive function status of older adults determines the social function and living quality of older adults, which is related to the healthy development and stability of the society. However, the impact of high or low ambient temperature on cognitive function in older adults remains unclear. Based on data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we comprehensively assessed the impact of ambient temperature on the cognitive function of older adults in this study. The findings exhibited that for each 1 °C ascent in monthly temperature of high temperature, the examination score of global cognitive function of older adults decreased by 0.48 (95% CI 0.21-0.74), which was greater than that of 0.14 (95% CI 0.06-0.25) for each 1 °C reduction in low temperature. Overall, the detrimental effect of high temperature on cognitive function in older adults was more significant than that of low temperature, including on the five sub-cognitive functions involved. Our research provides vital technical guidance and reference for the health protection and prevention of cognitive function of older adults in specific external environmental conditions under the current climatic variation and temperature rise.

The significance of serum Klotho to hearing loss: a potential protector under noise pollution.

The issue of hearing protection in the presence of noise pollution is of great importance in the fields of environmental science and clinical medicine. Currently, the clinical significance of Klotho in relation to hearing has not been revealed. The aim of this study was to examine the correlation between serum Klotho levels and Pure Tone Average (PTA) hearing thresholds among individuals in the U.S.. The analysis involved a sample of 1,781 individuals aged 20 to 69, obtained from the 2007-2012 National Health and Nutrition Examination Survey. Various methods were utilized for the analysis, including univariate and multivariate linear regression, stratified analysis, smooth curve fitting, a two-segment linear regression model, and log-likelihood ratio analysis. The results of the univariate analysis indicated that serum Klotho concentration, age, education level, hypertension, diabetes, and smoking all exhibited a significant influence on PTAs. After adjusting for potential confounding factors, it was observed that a decrease in serum Klotho was significantly associated with PTA thresholds at low frequency (ß = -0.002; 95% CI: -0.003, -0.001; P = 0.004), speech frequency (ß = -0.002; 95% CI: -0.003, -0.001; P = 0.007), and high frequency (ß = -0.002; 95% CI: -0.003, -0.001; P = 0.045). Specifically, for every 1 pg/ml decrease in serum Klotho concentration, the PTAs increased by 0.002 dB. Moreover, age and gender-specific analyses revealed significant associations. For individuals aged 59-69, a significant association was found between serum Klotho concentration and high-frequency PTA (ß = -4.153; 95% CI: -7.948, -0.358; P = 0.032). Additionally, among females, significant associations were observed between serum Klotho concentration and speech-frequency PTA (ß = -1.648, 95% CI: -3.197, -0.099; P = 0.037) as well as high-frequency PTA (ß = -3.046; 95% CI: -5.319, -0.772; P = 0.009). Finally, the results of smooth curve fitting and threshold effect analyses indicated a potential negative linear correlation between serum Klotho concentration and PTA thresholds. In conclusion, a lower level of serum Klotho was found to be associated with increased hearing thresholds, particularly among the elderly population. This finding has significant implications for the prevention and treatment of hearing damage.

Trends and Challenges in AIoT/IIoT/IoT Implementation.

For the next coming years, metaverse, digital twin and autonomous vehicle applications are the leading technologies for many complex applications hitherto inaccessible such as health and life sciences, smart home, smart agriculture, smart city, smart car and logistics, Industry 4.0, entertainment (video game) and social media applications, due to recent tremendous developments in process modeling, supercomputing, cloud data analytics (deep learning, etc.), communication network and AIoT/IIoT/IoT technologies. AIoT/IIoT/IoT is a crucial research field because it provides the essential data to fuel metaverse, digital twin, real-time Industry 4.0 and autonomous vehicle applications. However, the science of AIoT is inherently multidisciplinary, and therefore, it is difficult for readers to understand its evolution and impacts. Our main contribution in this article is to analyze and highlight the trends and challenges of the AIoT technology ecosystem including core hardware (MCU, MEMS/NEMS sensors and wireless access medium), core software (operating system and protocol communication stack) and middleware (deep learning on a microcontroller: TinyML). Two low-powered AI technologies emerge: TinyML and neuromorphic computing, but only one AIoT/IIoT/IoT device implementation using TinyML dedicated to strawberry disease detection as a case study. So far, despite the very rapid progress of AIoT/IIoT/IoT technologies, several challenges remain to be overcome such as safety, security, latency, interoperability and reliability of sensor data, which are essential characteristics to meet the requirements of metaverse, digital twin, autonomous vehicle and Industry 4.0. applications.

Advanced stimuli-responsive membranes for smart separation.

Membranes have been extensively studied and applied in various fields owing to their high energy efficiency and small environmental impact. Further conferring membranes with stimuli responsiveness can allow them to dynamically tune their pore structure and/or surface properties for efficient separation performance. This review summarizes and discusses important developments and achievements in stimuli-responsive membranes. The most commonly utilized stimuli, including light, pH, temperature, ions, and electric and magnetic fields, are discussed in detail. Special attention is given to stimuli-responsive control of membrane pore structure (pore size and porosity/connectivity) and surface properties (wettability, surface topology, and surface charge), from the perspective of determining the appropriate membrane properties and microstructures. This review also focuses on strategies to prepare stimuli-responsive membranes, including blending, casting, polymerization, self-assembly, and electrospinning. Smart applications for separations are also reviewed as well as a discussion of remaining challenges and future prospects in this exciting field. This review offers critical insights for the membrane and broader materials science communities regarding the on-demand and dynamic control of membrane structures and properties. We hope that this review will inspire the design of novel stimuli-responsive membranes to promote sustainable development and make progress toward commercialization.

Enhanced Yield of Large-Sized Ti3C2Tx MXene Polymers Nanosheets via Cyclic Ultrasonic-Centrifugal Separation.

Water pollution has spurred the development of membrane separation technology as a potential means of solving the issue. In contrast to the irregular and asymmetric holes that are easily made during the fabrication of organic polymer membranes, forming regular transport channels is essential. This necessitates the use of large-size, two-dimensional materials that can enhance membrane separation performance. However, some limitations regarding yield are associated with preparing large-sized MXene polymer-based nanosheets, which restrict their large-scale application. Here, we propose a combination of wet etching and cyclic ultrasonic-centrifugal separation to meet the needs of the large-scale production of MXene polymers nanosheets. It was found that the yield of large-sized Ti3C2Tx MXene polymers nanosheets reached 71.37%, which was 2.14 times and 1.77 times higher than that prepared with continuous ultrasonication for 10 min and 60 min, respectively. The size of the Ti3C2Tx MXene polymers nanosheets was maintained at the micron level with the help of the cyclic ultrasonic-centrifugal separation technology. In addition, certain advantages of water purification were evident due to the possibility of attaining the pure water flux of 36.5 kg m-2 h-1 bar-1 for the Ti3C2Tx MXene membrane prepared with cyclic ultrasonic-centrifugal separation. This simple method provided a convenient way for the scale-up production of Ti3C2Tx MXene polymers nanosheets.

Effects of d-ribose on human erythrocytes: Non-enzymatic glycation of hemoglobin, eryptosis, oxidative stress and energy metabolism.

d-Ribose is not only an important component of some biomacromolecules, but also an active pentose with strong reducibility and non-enzymatic glycation ability. Previous studies reported the diverse role of d-ribose in different cells. In this study, the effects of d-ribose on non-enzymatic glycation of hemoglobin (Hb), as well as eryptosis, oxidative stress and energy metabolism of erythrocytes were observed by molecular fluorescence spectrophotometry, multi-wavelength spectrophotometry, high-pressure liquid chromatography (HPLC), mass spectrometry (MS) and flow cytometer. The results showed that d-ribose had the strongest non-enzymatic glycation ability to Hb in vitro when compared with other monosaccharides, and could enter the erythrocytes in a concentration-dependent manner, which was not inhibited by the specific glucose transporter 1 (GLUT1) inhibitor WZB117. In addition, d-ribose incubation increased the HbA1c, hemolysis, eryptosis, and ROS level of erythrocytes significantly more than that of d-glucose, however, no changes were observed in the levels of ATP, NADPH, and other intermediate energy metabolites in d-ribose treatment. Therefore, the strong non-enzymatic glycation ability of d-ribose may play an important role in erythrocyte damage.

Role of the anterior choroidal artery in the endovascular treatment of brain arteriovenous malformations.

The anterior choroidal artery (AchA) is a very important vessel that supplies certain crucial structures that have poor collateral circulation. When the AchA is recruited to supply brain arteriovenous malformations (BAVMs), can the AchA act as a safe path through which endovascular treatment (EVT) be performed? As few studies or reports have investigated this matter, we performed a review to expound upon the role of the AchA in the EVT of BAVMs. In this review, we discussed the anatomy and variation of the AchA, the angioarchitecture of BAVMs fed by the AchA, the status of EVT for BAVMs and its associated problems and their solutions, the choice of embolic materials, new EVT techniques, the complications and prognoses of EVT through the AchA, etc. The review revealed that although EVT of BAVMs through the AchA is challenging and can result in unpredictable complications, it may be an appropriate option prior to surgery and radiation therapies or serve as a curative procedure. A complete and thorough understanding of the functional anatomy and variant of the AchA and proper EVT techniques are crucial for successful embolization of BAVMs via the AchA.

High ambient temperatures are associated with urban crime risk in Chicago.

Urban crime (UC) seriously affects the security and stability of the communities and society. However, the effects of external temperatures on the risk of UC are still confusing. We quantitatively estimated the effects of high and low temperatures on UC in Chicago. After controlling for the confounding factors, we found that high temperature has a positive promoting effect on UC, for non-domestic crime, the effect occurs at lag day 0 with a maximum risk of 1.40 (95%CI, 1.34-1.46) compared to a risk of 1 at temperature of -12.3 °C, and decreased as the lag day increased. The effect of low temperature is not significant for UC. Heat waves above the 99th percentile with a duration of 4.5-5.5 days exert a significant positive impact on non-domestic crime of UC. Our findings confirm the adverse promotion effect of high temperature on UC risk, and effective individual behavior guidance and administrative intervention are of great significance for reducing the risk of UC under specific high temperature environment.

The cytological and electrophysiological effects of silver nanoparticles on neuron-like PC12 cells.

The aim of this study was to investigate the toxic effects and mechanism of silver nanoparticles (SNPs) on the cytological and electrophysiological properties of rat adrenal pheochromocytoma (PC12) cells. Different concentrations of SNPs (20 nm) were prepared, and the effects of different application durations on the cell viability and electrical excitability of PC12 quasi-neuronal networks were investigated. The effects of 200 µM SNPs on the neurite length, cell membrane potential (CMP) difference, intracellular Ca2+ content, mitochondrial membrane potential (MMP) difference, adenosine triphosphate (ATP) content, and reactive oxygen species (ROS) content of networks were then investigated. The results showed that 200 µM SNPs produced grade 1 cytotoxicity at 48 h of interaction, and the other concentrations of SNPs were noncytotoxic. Noncytotoxic 5 µM SNPs significantly increased electrical excitability, and noncytotoxic 100 µM SNPs led to an initial increase followed by a significant decrease in electrical excitability. Cytotoxic SNPs (200 µM) significantly decreased electrical excitability. SNPs (200 µM) led to decreases in neurite length, MMP difference and ATP content and increases in CMP difference and intracellular Ca2+ and ROS levels. The results revealed that not only cell viability but also electrophysiological properties should be considered when evaluating nanoparticle-induced neurotoxicity. The SNP-induced cytotoxicity mainly originated from its effects on ATP content, cytoskeletal structure and ROS content. The decrease in electrical excitability was mainly due to the decrease in ATP content. ATP content may thus be an important indicator of both cell viability and electrical excitability in PC12 quasi-neuronal networks.

Change lifestyle modification plan/transtheoretical model in non-alcoholic simple fatty liver disease: a pilot randomized study.

BACKGROUND: Non-alcoholic simple fatty liver disease patients have very low compliance with almost all types of physical activities. A transtheoretical model-oriented lifestyle modification plan awakens the patient's consciousness in the pre-intention stage. Aim to evaluate whether a management by stages of change plan based on the Transtheoretical Model and Stages of Change promoted behavior change for patients with non-alcoholic simple fatty liver disease. METHODS: Patients with simple fatty liver diagnosed from July to December 2019 were randomly divided into the transtheoretical model and non-transtheoretical model groups. Primary outcome was change in health belief and health behavior based on questionnaires. Secondary outcomes included changes in blood lipids, body mass indexes, and waist circumference 12-months after intervention. RESULTS: Of 200 enrolled patients 194 were analyzed (non-transtheoretical model group n = 98, transtheoretical model group n = 96). After intervention, total health belief scores (120.91 ± 4.94 vs. 118.82 ± 5.48) and total health behavior scores (131.71 ± 5.87 vs. 119.96 ± 7.12) were higher in the transtheoretical model group (all P < 0.05). Blood lipids, body mass index, and waist circumference more obviously improved in the transtheoretical model group (all P < 0.05). CONCLUSION: A transtheoretical model-based lifestyle modification intervention can be effectively applied to patients with non-alcoholic simple fatty liver. CLINICAL RESEARCH REGISTRATION NUMBER: ChiCTR2100049354. The registration date is August 1, 2021.

Geo-Economic Linkages between China and the Countries along the 21st-Century Maritime Silk Road and Their Types.

With the advances of the Belt and Road Initiative (BRI), the geo-economic interactions between China and countries along the 21st-Century Maritime Silk Road counties (MSRCs) continue to increase, and analyzing the geo-economic relations between China and the MSRCs is extremely important for a scientific understanding of bilateral geo-economic cooperation. Differently from the traditional logic of geo-economic competition and cooperation, we constructed a new framework based on the dominant factors of geo-economic relations and used an extreme random forest regression model to classify the geo-economic relation types between China and MSRCs from 2006 to 2017. The results show that the unbalanced development of investment and trade between China and MSRCs hindered the enhancement of the intensity of bilateral geo-economic linkage from 2006 to 2017. The "Matthew effect" of China's geo-economic flow linkage with MSRCs is significant. There are obvious differences in the dominant factors affecting the types of geo-economic relations between China and MSRCs, and the distribution of the importance of the indices of the types of geo-economic relations in each country is disordered. Geopolitics, markets, and resources have played important roles in the geo-economic linkages between China and MSRCs. There are five types of geo-economic relations between China and the MSRCs: market-oriented type, resource-oriented type, market-resource-oriented type, market-geopolitics-oriented type, and resource-geopolitics-oriented type, of which the market-oriented type is the most important type of geo-economic relations. In the future, China should focus on regional powers along the Maritime Silk Road for bilateral geo-economic cooperation, actively promote the balanced development of bilateral geo-economic elements flows, strengthen geopolitical cooperation with MSRCs, and formulate cooperation plans according to the types of geo-economic relations.

The Choice of Anesthetic Drugs in Outpatient Hysteroscopic Surgery: A Systematic Review and Network Meta-Analysis.

Objective: Hysteroscopy is a minimally invasive gynecologic technique that is widely practiced in outpatient procedures. The choice of anesthesia is a key factor for the surgical outcome and postoperative recovery. This study was conducted to assess the effects of different anesthetic modalities based on dexmedetomidine in outpatient hysteroscopic surgery anesthesia. Methods: We did a systematic review and network meta-analysis of outpatient hysteroscopic surgery anesthesia. We searched Pubmed, Embase, and Cochrane-Library from database inception to December 31, 2021. Duplicate literature was excluded and screened separately for initial screening at three tiers: article title, abstract, and full text before deciding whether to include in this study against the above criteria. Results after analysis of categorical variables were expressed as ORR Ratio (95% CI) and continuous variables were expressed as Mean Difference (95% CI). Data collation and analyses were performed using the gemtc package in the R language. Results: Four trials were finally included with data for 301 participants, three anesthetic drugs, and five anesthetic modalities. A fixed-effects model was used for the different anesthesia modalities without significant heterogeneity (all I2<20%) in the analysis of adverse events (AEs), the incidence of respiratory depression, operative time, and time in the post-anesthesia care unit (PACU). Remimazolam tosylate was associated with a lower incidence of AEs versus dexmedetomidine, and significant differences between dexmedetomidine and propofol were absent. Propofol and various doses of remimazolam tosylate resulted in a lower incidence of respiratory depression versus dexmedetomidine, with an absence of differences between propofol and dexmedetomidine. The operative time for different anesthetic modalities was, in descending order, dexmedetomidine < remimazolam tosylate (0.60 mg/kg/h <0.48 mg/kg/h) < propofol < remimazolam tosylate (1.00 mg/kg/h), despite the absence of intergroup differences. Propofol was associated with a longer time in PACU versus dexmedetomidine and remimazolam tosylate (1.00 mg/kg/h); those of dexmedetomidine and remimazolam tosylate (1.00 mg/kg/h) were similar. The time in PACU for different anesthetic modalities, in descending order, was dexmedetomidine < remimazolam tosylate (1.00 mg/kg/h) < propofol. Propofol was associated with a longer time in PACU versus dexmedetomidine and remimazolam tosylate. Conclusion: In outpatient hysteroscopic surgery anesthesia, dexmedetomidine was associated with a higher incidence of AEs and respiratory depression and a shorter operative time and time in PACU versus remimazolam tosylate and propofol. Remimazolam tosylate showed safety benefits with a similar duration of PACU stay versus dexmedetomidine. Therefore, the choice of anesthetic drugs in outpatient surgery requires consideration of the patient's conditions and preferences.

Sports entertainment programs from the perspective of College student audience psychology spread excellent traditional Chinese culture / Los programas de entretenimiento deportivo desde la perspectiva de la psicología de la audiencia de los estudiantes universitarios difunden una excelente cultura tradicional china

This research will investigate the diffusion of great traditional Chinese culture through sports entertainment programs from a psychological standpoint. Based on the needs of the study and the actual investigation situation, this article employs the methods of literature, questionnaire, and mathematical statistics to select a total of 800 college students to participate in this survey to determine whether there are significant differences in the participation of college students of different genders and grades in traditional national sports. The survey indicated that college student engagement in traditional national sports is in an unfavorable state. College students pay more attention to traditional national sports, but their understanding is limited, their engagement is limited, and their average participation time is less than thirty minutes. Only when sports entertainment programs have more significant educational impacts from the standpoint of the audience's psychology will sports news be able to disseminate the superb traditional Chinese culture better. This study has significant consequences for the psychology of students.(AU)

Current status of perimesencephalic non-aneurysmal subarachnoid hemorrhage.

Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSAH) is a distinctive disease, representing SAH centered in perimesencephalic cisterns, with negative angiography findings. In recent years, the number of patients with PNSAH has increased significantly; however, the knowledge of PNSAH is insufficient. Therefore, we performed a review of the literature from a PubMed search and recounted our understanding of PNSAH. In this review, we summarized that current high-resolution computed tomography angiography is an acceptable replacement for digital subtraction angiography to rule out aneurysms in PNSAH with strict criteria. The current hypothesis about the etiology of PNSAH is that there is deep vein rupture from aberrant venous anatomy and increased intracranial venous pressure. PNSAH is associated with mild symptoms and lower rates of hydrocephalus and symptomatic vasospasm. For PNSAH, conservative treatment has been the mainstream treatment. PNSAH has a benign clinical course and an excellent prognosis; in long-term follow-up, re-bleeding and death were uncommon.