Effect of prior anticoagulation therapy on outcomes of traumatic brain injury: A systematic review and meta­analysis.

Anticoagulants are commonly prescribed for multiple conditions. However, their influence on traumatic brain injury (TBI) outcomes, especially mortality, is not clear. The present study aimed to explore the effect of prior anticoagulation treatment on the outcomes of TBI. PubMed, Embase, Cochrane Central Register of Controlled Trials, Scopus and CINAHL databases were systematically searched for studies on individuals diagnosed with TBI, with a subgroup on prior anticoagulation therapy. Outcomes of interest included overall mortality, in-hospital mortality, length of hospital and intensive care unit stay, need for neurosurgical intervention and discharge rate. Cohort and case-control studies, published up to September 2023, were examined. Analysis was performed using STATA version 14.2 software and the Newcastle Ottawa Scale was used for bias assessment. A total of 22 studies (102,036 participants) were included in the analysis. Patients with TBI with prior anticoagulation treatment showed a statistically higher overall mortality risk [odds ratio (OR): 1.967, 95% confidence interval (CI): 1.481-2.613]. Subgroup analyses revealed age-specific and TBI severity-specific variations. Prior anticoagulation treatment was associated with a 1.860-times higher rate of in-hospital mortality and a significantly increased likelihood of requiring neurosurgical intervention (OR: 1.351, 95%CI: 1.068-1.708). However, no significant difference was noted in lengths of hospital or ICU stays. Patients with TBI and prior anticoagulation therapy are at higher risk of overall and in-hospital mortality and have significantly higher likelihood of needing neurosurgical interventions. The results emphasized the need for tailored therapeutic approach and more comprehensive clinical guidelines. Future investigations on specific anticoagulant types and immediate post-TBI interventions could offer further insights.

The first species of Nazeris from Shenzhen City, Guangdong, China (Coleoptera, Staphylinidae, Paederinae).

N/A.

Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes.

Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 µM.

Three new species of Nazeris Fauvel from the Jiuwan Mountain, Guangxi, China (Coleoptera, Staphylinidae, Paederinae).

Three new species of Nazeris Fauvel, 1873 from the Jiuwan Mountain, Guangxi, China, are described and illustrated: N. jiuwanensis, sp. n., N. qingshuius, sp. n. and N. yangmeius sp. n. An identification key to the Nazeris species in Guangxi is provided.

The Nazeris fauna in Xizang, China (Coleoptera, Staphylinidae, Paederinae).

Nine species of Nazeris Fauvel are reported from Xizang, China. Seven of them are described as new: N. mirabilis sp. n., N. dinggyensis sp. n., N. jifuensis sp. n., N. wenxuani sp. n., N. gladius sp. n., N. gyirongensis sp. n. and N. yadongensis sp. n. An identification key to the Nazeris species in Xizang and a map showing their distribution are provided.

Subcellular distribution and chemical forms of manganese in Daucus carota in relation to its tolerance.

Daucus carota is a biennial herb of the Umbelliferae family, which is a candidate plant for the phytoremediation of Mn pollution. To reveal the mechanism of this plant to adapt to Mn stress, plant growth, anatomical structure, Mn accumulation characteristic, Mn subcellular distribution, and chemical forms of D. carota under six Mn2+ concentrations by pot culture experiments were studied. The results showed that with the rising Mn concentrations, the total dry weight and leaf area of D. carota increased firstly and then decreased, while the specific leaf area increased. The thickness of the main vein, upper epidermis, and lower epidermis; the thickness of the palisade tissue; and the thickness of the spongy tissue of the leaves increased firstly and then decreased. The Mn content in the aboveground and underground parts of D. carota increased, and the values of the bioconcentration factor (BCF) and translocation factor (TF) were higher than 1. The Mn existing in the cell wall and soluble components accounted for the largest proportion, and the proportion of Mn in the cell wall increased with increasing concentrations of Mn. In addition, Mn mainly existed in ethanol extraction state, deionized water extraction state, and sodium chloride extraction state. The results showed that D. carota could alleviate the damage caused by high manganese concentration by storing most of manganese in the cell wall and vacuole and existing in the form of low-activity state.

The Nazeris fauna of the Leigong Mountain, Guizhou, China (Coleoptera, Staphylinidae, Paederinae).

Seven species of Nazeris Fauvel, 1873 are reported for Guizhou, China. All of them are described as new: N. ingentis Lin, Yu Hu, sp. n., N. resimus Lin, Yu Hu, sp. n., N. leigongensis Lin, Yu Hu, sp. n., N. yujiei Lin, Yu Hu, sp. n., N. muricatus Lin, Yu Hu, sp. n., N. excertus Lin, Yu Hu, sp. n. and N. serratus Lin, Yu Hu, sp. n.

Caulophyine A, a Rare Azapyrene Alkaloid from the Roots of Caulophyllum robustum.

A novel alkaloid caulophyine A (1) was isolated from the roots of Caulophyllum robustum Maxim., along with six known alkaloids 2-7. The structure of 1 was elucidated by extensive NMR and high resolution-time-of-flight (HR-TOF)-MS analyses, it is a rare nitrogen containing polycyclic aromatic hydrocarbon. The in vitro bioassays revealed that 2 presented remarkable cytotoxicity against A549 with an IC50 value of 3.83 µM in comparison with the positive control etoposide (IC50 = 11.63 µM). Compounds 1 and 2 also displayed weak Acetylcholinesterase (AChE) inhibitory activity with IC50 values of 123.03 and 80.74 µM respectively.

Acrocalyenes A and B, Two New Diterpenoids from Sinomenium acutum Associated Fungus Acrocalymma sp.

We identified two new diterpenoidal acrocalyenes A (1) and B (2) through chemical investigation on Acrocalymma sp., a plant-associated fungus from the tender stem isolates of Sinomenium acutum collected from the Qinling Mountains, along with seven already-recognized compounds (3-9). The HR-ESI-TOF-MS and 1D/2D NMR data were utilized for structural elucidation of these compounds, and the single-crystal X-ray diffraction was employed for absolute configuration clarification of the novel acrocalyenes 1 and 2. Bioassays revealed that the cytotoxicities of compounds 2, 4, 6, 7, and 8 against three human carcinoma cells (RKO, HeLa and HCC-1806) were moderate to strong, with IC50 between 6.70-38.82 µM. These isolates were also evaluated for their fungal resistant potentials against Botrytis cinerea, Fusarium culmorum and Fusarium solani, in which 3 displayed significant inhibitory effects on all three phytopathogenic fungi, showing respective MIC of 50, 25 and 25 µM.

New data of Nazeris Fauvel from the Dayao Mountains, Guangxi, China (Coleoptera, Staphylinidae, Paederinae).

Three new species of Nazeris Fauvel, 1873 from the Dayao Mountains, Guangxi, China, are described and illustrated: N. shengtangus Ma, Miao Hu, sp. n., N. songi Ma, Miao Hu, sp. n., and N. curvilaminatus Ma, Miao Hu, sp. n. An identification key to the Nazeris species in Guangxi, and a map showing their distribution are provided.

New species and records of Anchocerus Fauvel in China (Coleoptera: Staphylinidae: Staphylininae).

Two species of Anchocerus Fauvel are reported from China, one of them described as new: A. wenxuani Lin Hu, sp. n. (Guangxi). Anchocerus giganteus Hu, Li Zhao, 2010 is newly recorded from Shanghai, Jiangxi, Guangxi and Guangdong. A map showing the distribution of all Chinese species is provided.

The Nazeris fauna of the Nanling Mountain Range, China (Coleoptera, Staphylinidae, Paederinae).

Fourteen species of Nazeris Fauvel, 1873 are reported for the Nanling Mountain Range, China. Four of them are described as new: N.xingmini Lin & Hu, sp. nov. (Guangdong, Jiangxi), N.huaiweni Lin & Hu, sp. nov. (Guangdong), N.meihuaae Lin & Hu, sp. nov. (Guangdong, Jiangxi) and N.lichongi Lin & Hu, sp. nov. (Hunan). An identification key to the Nazeris species reported for the Nanling Mountains, and a map showing their distribution are provided.

A new species of Quedius Stephens in Zhejiang, China (Coleoptera, Staphylinidae, Staphylinini).

N/A.

Phylogeny and Density Dynamics of Wolbachia Infection of the Health Pest Paederus fuscipes Curtis (Coleoptera: Staphylinidae).

The maternally inherited obligate intracellular bacteria Wolbachia infects the reproductive tissues of a wide range of arthropods and affects host reproduction. Wolbachia is a credible biocontrol agent for reducing the impact of diseases associated with arthropod vectors. Paederus fuscipes is a small staphylinid beetle that causes dermatitis linearis and conjunctivitis in humans when they come into contact with skin. Wolbachia occur in this beetle, but their relatedness to other Wolbachia, their infection dynamics, and their potential host effects remain unknown. In this study, we report the phylogenetic position and density dynamics of Wolbachia in P. fuscipes. The phylogeny of Wolbachia based on an analysis of MLST genotyping showed that the bacteria from P. fuscipes belong to supergroup B. Quantitative PCR indicated that the infection density in adults was higher than in any other life stage (egg, larva or pupa), and that reproductive tissue in adults had the highest infection densities, with similar densities in the sexes. These findings provide a starting point for understanding the Wolbachia infection dynamics in P. fuscipes, and interactions with other components of the microbiota.

New data of Nazeris Fauvel in Anhui, China (Coleoptera, Staphylinidae, Paederinae).

A new species of Nazeris Fauvel, 1873 from Anhui, China, is described and illustrated: N. yaoluopingus, sp. n. Additional records of N. cultellatus Assing, 2013, an identification key to the Nazeris species in Anhui and a map showing their distribution are provided.

Five new species of Nazeris Fauvel in Guangxi, China (Coleoptera, Staphylinidae, Paederinae).

Six species of Nazeris Fauvel are reported for Guangxi, China. Five of them are described as new: N. maoershanus Hu Qiao, sp. n., N. rugosus Hu Qiao, sp. n., N. yuyimingi Hu Qiao, sp. n., N. biacuminatus Hu Qiao, sp. n., and N. yanzhuqii Hu Qiao, sp. n. Additional records of N. latilobatus Assing, 2016 and an identification key to the Nazeris species in Guangxi are provided.

New species and record of Nazeris Fauvel in southern China (Coleoptera, Staphylinidae, Paederinae).

Four species of Nazeris Fauvel are reported from Guangdong and Hunan, China, with three of them described as new: N. rubidus Hu, Luo Li, sp. n., N. nanlingensis Hu, Luo Li, sp. n., and N. gaoleii Hu, Luo Li, sp. n. Nazeris inaequalis Assing, 2014 is newly recorded from Guangdong Province.

Two new species of Nazeris Fauvel in the Luoxiao Mountain Range, China(Coleoptera, Staphylinidae, Paederinae).

Six species of the genus Nazeris Fauvel, 1873 are recorded in the Luoxiao Mountain Range, China. Two of them are described: N. yipingae sp. n. and N. jiaweii sp. n. Nazeris xiaobini Hu Li, 2015 and N. rufus Hu Li, 2015 are newly recorded from Hubei Province. An identification key to the Nazeris species in this area and a map showing their distribution are given.

Sinopestalotiollides A-D, cytotoxic diphenyl ether derivatives from plant endophytic fungus Pestalotiopsis palmarum.

Four new diphenyl ether derivatives, sinopestalotiollides A-D (1-4), one new natural α-pyrone product (11), as well as twelve known compounds (5-1 7), were obtained from the ethyl acetate extract of the endophytic fungus Pestalotiopsis palmarum isolated from the leaves of medicinal plant Sinomenium acutum (Thunb.) Rehd et Wils. The structures were elucidated by HR-ESI-MS and NMR spectrometry data. Bioassay experiments revealed that compounds 1-4 and 11 exhibited strong to weak cytotoxicities against three human tumor cell lines Hela, HCT116 and A549.

New data of Nazeris Fauvel in Xizang, China (Coleoptera, Staphylinidae, Paederinae).

A new species of Nazeris Fauvel, 1873 from Xizang, China, is described and illustrated: N. zhifeii Hu Pan, sp. n. A key to Nazeris species in Xizang and a map showing their distribution are given.