ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis.

OBJECTIVES: To screen and verify differential genes affecting the prognosis of breast cancer. METHODS: Breast cancer gene expression datasets were downloaded from the GEO database, and original data were analyzed in R. The TIMER database was used to analyze the relationship between ANLN and UBE2T and immune cell infiltration. RESULTS: Ten hub-key genes were identified, and survival analysis showed that UBE2T and ANLN were upregulated in breast cancer and their upregulation was associated with a poor prognosis. ANLN and UBE2T upregulation was associated with the prevalence of Th1 and Th2 cells, shifting the Th1/Th2 balance to Th2 in Basal and Luminal-B breast cancers, which indicates a poor prognosis (P < 0.05). CONCLUSION: ANLN and UBE2T are potential biomarkers for predicting the prognosis of breast cancer.

Catalytically Active Carbon From Cattail Fibers for Electrochemical Reduction Reaction.

Catalytically active carbons derived from plant biomass are conducive to the construction of renewable energy source system and utilization of sustainable resources. In this article, natural cattail fibers are used to fabricate porous nitrogen-doped carbon via direct chemical activation and heteroatom modification treatments. The graphene-like sheets from biomass pyrolysis are assembled into three-dimensional carbon frameworks. The chemical activation of KHCO3 generated unique porous structure and N-containing molecules pyrolysis modification provided nitrogen doping atoms. High surface area up to 2,345 m2·g -1 with simultaneous hierarchical pores (from micro to meso and macro) with abundant edge defects are achieved for these carbon materials. These materials have a very large external surface area up to 1,773 m2·g -1. The above strategy exhibits a significant synergistic effect on the improvement of catalytic properties toward hydrogen evolution reaction and oxygen reduction reaction. The small over potentials and Tafel slopes of these catalytically active carbons demonstrate excellent potential applications in renewable energy conversion and storage systems. This research established a new link among environmental improvement, biomass conversion and renewable energy utilization.