1.
Chem Commun (Camb)
; 58(66): 9294-9297, 2022 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35904428
RESUMO
Herein, we describe an N-heterocyclic carbene (NHC)-catalyzed deconstructive isomerization of azetidinols via an inert C-C bond cleavage. It provides a direct and supplementary pathway to access α-amino ketone and oxazol-2-one derivatives in moderate to good yields. DFT calculation supports the proposed mechanism in which NHC undergoes a concerted proton transfer and ring-opening process. This reaction features non-metal catalysis, simple reaction operation, excellent regioselectivity and gram-scale synthesis.