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1.
Diagn Microbiol Infect Dis ; 110(1): 116347, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38878341

RESUMO

In this article we report a case of disseminated nocardiosis caused by Nocardia otitidiscaviarum in an immunocompetent patient with chronic obstructive pulmonary disease (COPD) who complained of a cough, followed by skin and intracranial lesions. On metagenomic next-generation sequencing (mNGS) technology of respiratory samples (bronchoalveolar lavage fluid, BALF) Nocardia otitidiscaviarum was identified. The patient was treated with therapy combined with a low dose of TMP-SMX and imipenem cilastatin sodium and had a favorable outcome. The timely diagnosis of Nocardia with the help of mNGS technology and early rational treatment of TMP-SMX can help improve the prognosis.


Assuntos
Antibacterianos , Líquido da Lavagem Broncoalveolar , Nocardiose , Nocardia , Humanos , Nocardiose/diagnóstico , Nocardiose/microbiologia , Nocardiose/tratamento farmacológico , Nocardia/isolamento & purificação , Nocardia/genética , Antibacterianos/uso terapêutico , Líquido da Lavagem Broncoalveolar/microbiologia , Masculino , Sequenciamento de Nucleotídeos em Larga Escala , Idoso , Doença Pulmonar Obstrutiva Crônica/complicações , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Combinação Imipenem e Cilastatina/uso terapêutico , Resultado do Tratamento , Metagenômica
2.
Environ Technol ; 36(5-8): 1008-15, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25323028

RESUMO

The polycyclic aromatic hydrocarbons (PAHs) in crumb tyre rubber were firstly degraded under UV irradiation in the presence of rutile TiO2 and hydrogen peroxide. The effects of light intensity, catalyst amount, oxidant amount, initial pH value, co-solvent content, and reaction time on degradation efficiency of typical PAHs in crumb tyre rubber were studied. The results indicated that UV irradiation, rutile TiO2, and hydrogen peroxide were beneficial to the degradation of PAHs and co-solvent could accelerate the desorption of PAHs from crumb tyre rubber. Up to 90% degradation efficiency of total 16 PAHs could be obtained in the presence of rutile TiO2 (1 wt%) and hydrogen peroxide (1.0 mL) under 1800 µW cm(-2) UV irradiation for 48 h. The high molecular weight PAHs (such as benz(a)pyrene) were more difficult to be degraded than low molecular weight PAHs (such as phenanthrene, chrysene). Moreover, through the characterization of reaction solution and degradation products via GC-MS, it was proved that the PAHs in crumb tyre rubber were successfully degraded.


Assuntos
Fotólise , Hidrocarbonetos Policíclicos Aromáticos/química , Hidrocarbonetos Policíclicos Aromáticos/efeitos da radiação , Borracha , Titânio , Raios Ultravioleta
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