[Analysis of Clinicopathological Characteristics of 88 Cases with Secondary Neoplasms of the Thyroid Gland].

Objective: To analyze the clinicopathological characteristics of secondary neoplasms of the thyroid gland (SNTGs). Methods: SNTG Patients who had pathology diagnosis of SNTGs between January 2010 and December 2019 at West China Hospital, Sichuan University were retrospectively enrolled. The SNTG cases were divided into two groups, a local invasion group and a distant metastasis group, and their clinical features were reviewed. Results: The study involved 88 patients, with a female-to-male (F/M) ratio of 1/3 and an average age of 56 years. The local invasion group consisted of 72 patients (F/M, 1/8) who had the following types of tumors: 65 had squamous cell carcinomas (45 originated from larynx and 10 from laryngopharynx), 4 had adenoid cystic carcinomas, 1 had neuroendocrine carcinoma of esophagus, 1 had giant cell tumor, and 1 had type B3 thymoma. The distant metastasis group consisted of 16 patients (F/M, 7/1), all with previously confirmed history of malignancies of sites distant from the thyroid. Their primary tumor types were as follows, 6 had breast carcinomas, 5 had lung adenocarcinomas, 2 had nasopharyngeal non-keratinizing carcinomas, 1 had clear cell renal carcinoma, 1 had colon adenocarcinoma, and 1 had cervical squamous cell carcinoma. Conclusions: Given that SNTGs are generally rare, the local invasion cases were predominantly squamous cell carcinomas that mainly originated from the larynx and the patients usually had no previous history of malignancy, while the distant metastasis cases often had a corresponding history of malignancies, consisting mainly of breast carcinoma and lung carcinoma.

Effects of parent-child painting and creative crafting therapy on preschool children with autism spectrum disorder and their mothers: a prospective randomized controlled trial. / äº²å­ç»˜ç”»å’Œåˆ›æ„æ‰‹å·¥ç–—æ³•å¯¹å­¦é¾„å‰æœŸå­¤ç‹¬ç—‡è°±ç³»éšœç¢å„¿ç«¥åŠå ¶æ¯äº²æ•ˆæžœè¯„ä»·çš„å‰çž»æ€§éšæœºå¯¹ç §ç ”ç©¶.

OBJECTIVES: To study the effects of parent-child painting and creative crafting therapy on the core symptoms of preschool children with mild-to-moderate autism spectrum disorder (ASD) and the parenting stress and hope level of their mothers. METHODS: A total of 56 preschool children with mild-to-moderate ASD and their mothers were divided into an experimental group and a control group using the block randomization method, with 28 pairs in each group. The subjects in the control group received an applied behavior analytic intervention and those in the experimental group received parent-child painting and creative crafting therapy in addition to the intervention in the control group. The intervention time was 20 weeks for both groups. Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Parenting Stress Index-Short Form (PSI-SF), and Herth Hope Index (HHI) were used to evaluate the core symptoms of children and the parenting stress and hope level of their mothers before and after 20 weeks of intervention. RESULTS: Forty-nine child-mother pairs completed the study (25 pairs in the intervention group and 24 pairs in the control group). The children in the experimental group had significantly lower scores of social interaction, language, social communication, and social motivation and total scores of ABC and SRS compared with those in the control group (P<0.05). The mothers in the experimental group had significantly lower scores of parental distress and parent-child dysfunctional interaction and total score of PSI-SF (P<0.05) and significantly higher total score of HHI and scores of each dimension compared with those in the control group (P<0.05). CONCLUSIONS: The combination of applied behavior analytic intervention with parent-child painting and creative crafting therapy can more effectively improve the core symptoms and social interaction of preschool children with mild-to-moderate ASD, reduce the parenting stress of mothers and improve their hope level.

[Curative effect of progressively integrated sandplay therapy on core symptoms and sleep management in preschool children with mild-to-moderate autism spectrum disorder].

OBJECTIVE: To explore the curative effect of progressively integrated sandplay therapy on core symptoms and sleep management in preschool children with mild-to-moderate autism spectrum disorder (ASD). METHODS: A total of 50 mild-to-moderate ASD preschool children were randomly divided into an experimental group (n=25) and a control group (n=25). The control group was treated with structured teaching and auditory integration training (AIT). Based on these, the experimental group was treated with progressively integrated sandplay therapy. The Autism Behavior Checklist (ABC), Children Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), Children's Sleep Habit Questionnaire (CSHQ) and emotion recognition tools were used to evaluate the overall curative effect before treatment and 3 months after treatment. RESULTS: The experimental group had significantly lower scores of feeling, social interaction, somatic motor, language factor, total ABC and total CARS than the control group (P<0.05). The experimental group had also significantly lower scores of social cognition, social communication, social motivation, autistic behavior factor and total SRS than the control group (P<0.05). The experimental group had a significantly higher accurate rate of recognition of the upper facial expression and lower facial expression than the control group (P<0.05). The experimental group had significantly lower scores of bedtime resistance, sleep onset, sleep duration, night waking, daytime sleepiness, and total CSHQ than the control group (P<0.05). The experimental group had significantly reduced themes of wounding and significantly increased themes of healing after sandplay therapy (P<0.05). CONCLUSIONS: Progressively integrated sandplay therapy can effectively improve the core symptoms and sleep quality of preschool children with mild-to-moderate ASD, which can be used as an early rehabilitation measure.

Elucidating the effects of solar panel waste glass substitution on the physical and mechanical characteristics of clay bricks.

This study deals with the effect of solar panel waste glass on fired clay bricks. Brick samples were heated to temperatures which varied from 700-1000 degrees C for 6 h, with a heating rate of 10 degrees C min(-1). The material properties of the resultant material were then determined, including speciation variation, loss on ignition, shrinkage, bulk density, 24-h absorption rate, compressive strength and salt crystallization. The results indicate that increasing the amount of solar panel waste glass resulted in a decrease in the water absorption rate and an increase in the compressive strength of the solar panel waste glass bricks. The 24-h absorption rate and compressive strength of the solar panel waste glass brick made from samples containing 30% solar panel waste glass sintered at 1000 degrees C all met the Chinese National Standard (CNS) building requirements for first-class brick (compressive strengths and water absorption of the bricks were 300 kg cm(-2) and 10% of the brick, respectively). The addition of solar panel waste glass to the mixture reduced the degree of firing shrinkage. The salt crystallization test and wet-dry tests showed that the addition of solar panel waste glass had highly beneficial effects in that it increased the durability of the bricks. This indicates that solar panel waste glass is indeed suitable for the partial replacement of clay in bricks.

[Effect of guizhi plus gegen decoction on ultrastructural changes of intervertebral disc annulus fibrosus cells].

OBJECTIVE: To observe the effect of Guizhi plus Gegen Decoction (GGD) on ultrastructural changes of intervertebral disc annulus fibrosus cells. METHODS: Rats' intervertebral disc annulus fibrosus cells were isolated and cultured using adherence wall screening method. After annulus fibrosus cells were intervened by GGD, the microstructure and ultrastructural features of untreated annulus fibrosus cells and annulus fibrosus cells treated by GGD containing serum at different concentrations were observed under optical microscope and electron microscope. RESULTS: Under optical microscope, most annulus fibrosus cells showed irregular polygons and few in star shape with rich superficial ecphyma. The nuclei were oval, large and complete. Under electron microscope, most cells in the blank group were oval after intervened by GGD containing serum at different concentrations. The nucleus was large, deviated, and irregular, the heterochromatin scattered diffusely, partial mitochondria vacuolized, and rough endoplasmic reticulum dilated. In the low dose GGD group, increased mitochondria and condensed density could be seen. The rough endoplasmic reticulum were expanded, lipid drops or glycogen could be occasionally seen. In the middle dose GGD group, increased endoplasmic reticulum expansion and condensed density could be seen. More medium density protein sediment could be seen. Increased mitochondria with condensed density could be seen, showing irregular cystic form with various sizes nucleus. In the high dose GGD group, increased rough endoplasmic reticulum with obvious expansion could be seen. More high density protein sediment could be seen. The nuclei were deviated. More mitochondria could be seen with secretory granules in them. CONCLUSIONS: After intervened by GGD containing serum at different concentrations, the ultrastructure of annulus fibrosus cells were manifested as follows: (1) The endoplasmic reticulum increased more in the middle and high dose GGD groups than in the blank group and the low dose GGD group. Greater density protein sediment occurred, especially in the high dose GGD group. (2) GGD played an important role in preventing ultrastructural changes induced by the degeneration of annulus fibrosus cells.