Nano-hydroxyapatite/Polyamide 66 cage in anterior cervical corpectomy and fusion: a comprehensive systematic review and meta-analysis.

OBJECTIVE: This study aimed to conduct a meta-analysis to compare the effectiveness and safety between titanium mesh cage (TMC) and nano-hydroxyapatite/polyamide 66 cage (n-HA/PA66) in the surgical treatment of cervical spondylotic myelopathy (CSM) through anterior cervical corpectomy and fusion (ACCF). MATERIALS AND METHODS: We implemented a comprehensive search strategy across multiple databases, including Wanfang, China Knowledge Network, China Biomedical Literature Database, Wipu, PubMed, Cochran, Embase, and Web of Science. To ensure a thorough examination of available literature, the databases were searched from their inception to January 2023. Two independent researchers evaluated the quality of the included studies by using established criteria. We used RevMan 5.4 (Review Manager Web, The Cochrane Collaboration, Copenhagen, Denmark) to facilitate data extraction and analysis. RESULTS: This analysis included seven controlled clinical studies. The meta-analysis results showed no statistically significant differences between the two groups in terms of operating time, intraoperative bleeding, preoperative Japanese Orthopedic Association (JOA) score, preoperative visual analog scale (VAS) score, preoperative and final follow-up C2-7 Cobb angles, and intervertebral fusion rate (p > 0.05). However, a significant difference was observed between the two groups in terms of the final follow-up JOA [MD = 0.77, 95% CI (0.58, 0.97), p < 0.00001], VAS [MD = -0.50, 95% CI (-0.71, -0.30), p < 0.00001], and sedimentation rate [RR = 0.30, 95% CI (0.18, 0.48), p < 0.00001]. CONCLUSIONS: The use of n-HA/PA66 in ACCF for treating CSM is safe and effective treatment with positive clinical efficacy. In addition, n-HA/PA66 has both effective clinical efficacy and significantly lower fusion settling rates compared to TMC.

Serotonergic serotonin 2 receptor modulation on DOPAC and 5-HIAA levels in rat striatum and nucleus accumbens: microdialysis studies of freely moving rats.

1. In vivo microdialysis with microbore-HPLC/ECD was employed to examine and compare changes of monoaminergic metabolites, dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus accumbens (NuAc) and the neostriatum (Str) of freely moving rats, following systemic administration of the specific 5-HT(2) analogue. 2. The 5-HT(2) agonist decreased DOPAC and 5-HIAA in both the NuAc and Str. However, the effect produced by apomorphine only decreased the DOPAC level in these two areas. 3. This effect did not occur in the rats that had been pretreated with the serotonin (5-HT) depleting agent. However, the effect was found in the rats that the striatal neurons had been damaged. 4. The 5-HT(2) effect regulated the mesencephalic dopamine (DA) synthesis/turnover only when entirely influenced by 5-HT. The striato-nigral feedback loop was not involved in this effect. Additionally, presynaptic relationship probably occurred between the 5-HT and its innervated DA pathways.