A multi-lesional analysis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a single-centre analysis.

AIM: To conduct a multi-lesional computed tomography (CT) analysis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) patients to determine volumetric changes in lesions over 5 years. MATERIALS AND METHODS: A retrospective case-note review was undertaken to identify 16 patients with histological and radiological features of DIPNECH between 2012-2021. Area and volume were calculated for 17 sets of lesions identified on high-resolution CT. Clinical data were extracted from electronic patient records, which included demographic data, outpatient clinic letters, histology reports, and imaging reports. RESULTS: One hundred and twenty-eight lesions were identified in 16 patients (one male, 15 female) and followed-up annually over a median 1,985 days (range 1,450-2,290). At year 1 follow-up, lesion area ranged from 1-48 mm2, and lesion volume ranged from 8-18,380 mm3; lesion area ranged from 1-45mm2 and lesion volume ranged from 11-17,800 mm3 and year 5. Half (8/16) of the patients had concomitant typical carcinoid tumours and one patient had an atypical carcinoid tumour. No statistically significant correlation (p<0.05) was found between lesion cross-sectional area or volume and duration of follow-up (years and days). No metastatic spread was observed at the time of analysis. CONCLUSIONS: No significant increase was observed in the size of over 100 lesions in patients with DIPNECH over a 5-year period and no metastasis occurred during the study period affirming the relatively indolent course of the disease.

Large scale three - dimensional laboratory measurements of tsunami inundation

Field survey results from recent tsunamis have substantiated numerous anecdotal reports over the past ten years of substantial differences between the runup predictions of numerical models and field measurements. These differences have led to speculations on whether these differences are due to poor seismological inferences about the tsunami source motions or whether they are due to poor perfomance of the hydrodynamic models. Based on a preliminary data analysis, it is concluded that the runup height normalized with the offshore depth increases almost linearly with the normalized source length, at least for nearshore generation. Also, under identical initial conditions, runup heights in a flume are higher than in a basin (AU)

Benefícios do acesso aberto

Os pesquisadores Chris McManus (University College London), Ewan Birney (European Bioinformatics Institute), Kuan-Teh Leang (National Institutes of Health) e Simon Hughes (King's College London) falam sobre os benefícios do acesso aberto. Arquivo disponível no link ao lado.