Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline.

An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 µg⋅h/ml and 1435.72893 µg⋅h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels.

[One new truxillic amide compound from Abrus mollis leaves].

The butanol extract part was extracted and isolated with water, alcohol and different organic solvents from Abrus mollis leaves. 6 compounds were isolated and purified using various column chromatographies and identified with the spectral techniques such as UV, MS, TLC, HPLC and NMR. The structures of 6 compounds were trigonelline (1), praline (2), alanine anhydride (3), (Z)-N-(4-hydroxycinnamoyl)tyrosine (4), (E)-N-(4-hydroxycinnamoyl)tyrosine (5), and abrusamide C (6). Compound 6 is a new compound, and compounds 1-4 were isolated from the plant for the first time.

[Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets].

OBJECTIVE: To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets. METHOD: The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not. RESULT: Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h. CONCLUSION: The maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.

[Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].

OBJECTIVE: To analyze and compare the composition of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC. METHODS: The fingerprints of Radix Salviae Miltiorrhizae were detected by HPLC and TLC. RESULTS: Radix Salviae Miltiorrhiza collected from different habitats showed diverse fingerprints of component. The content of tanshinone II A of Radix Salviae Miltiorrhizae in Shandong was the highest, which is 3.5 times higher than Shangluo of Shanxi province. CONCLUSION: The character of two analytical mehods with fingerprint of component is significant, simplicity, and reproducibility is great. The methods can be used to select Radix Salviae Miltiorrhizae for clinical and resarch institution.