CATHETER DIRECTED THROMBOLYSIS IN ACUTE LIMB ISCHEMIA PATIENTS. A SINGLE CENTER'S EXPERIENCE.

OBJECTIVE: The aim: This study evaluates catheter-directed thrombolysis (CDT) outcomes in patients with acute lower limb arterial thrombosis and acute limb ischemia. PATIENTS AND METHODS: Materials and methods: 53 patients (17 females, 36 males, aged 53-76) were studied. 57% had femoropopliteal and below-the-knee (BTK) thromboocclusion, 43% had BTK thromboocclusion. Symptoms included pain, pallor, edema, and cyanosis. Exclusions criteria: contracture, recent surgeries, bleeding. RESULTS: Results: In 29 (97%) patients regression of lower-limb ischemia rate by 1-2 stages according to the Rutherford classification were observed. One patient (3%) did not exhibit any regression in the degree of lower-limb ischemia, experiencing increasing pain and decreased sensitivity in the lower limb, leading to the development of contracture in the ankle joint and subsequent lower limb amputation over 7 days. Among 12 (40%) patients, after performing follow-up arteriography of the lower limb, angioplasty was performed on the diagnosed steno-occlusive lesions in the revascularized segment with secondary angioplasty. Within a year, one (3%) patient experienced recurrent thrombosis of the lower limb arteries with subsequent revascularization. CONCLUSION: Conclusions: CDT is recommended for ALI Patients with arterial thrombooclusion.

ENDOVASCULAR DIAGNOSTICS AND TREATMENT OF HEMORRHAGES IN MILITARY AND CIVILIAN PATIENTS FOLLOWING ABDOMINAL SURGERY.

OBJECTIVE: The aim: The retrospective analysis of the angiographic picture and clinical results of endovascular treatment of patients with postoperative abdominal and gastrointestinal bleeding was carried out. PATIENTS AND METHODS: Materials and methods: The results of 447 endovascular diagnostic and therapeutic interventions in 391 patients (46 military and 345 civilians) with postoperative bleeding performed from 2012 to 2022 were studied. According to computer tomography with contrast enhancement, the source of bleeding was identified in 216 (67.7%) cases. RESULTS: Results: In 345 (88.2%) patients, it was possible to reliably identify the source of bleeding on angiography. In 46 (11.8%) patients with an unexplained source of bleeding, the target arterial pool was determined on the basis of localization, volume, and features of surgical intervention and considered as preventive interventions. A total of 447 endovascular hemostatic interventions were performed on 391 patients. A stent graft was installed in 27 patients, 420 embolization were performed in 364 patients. Thus, in 43 (11.0%) patients, embolization was performed repeatedly, in 12 cases - three times, in 1 case - four times. In 16 cases (15 cases of prophylactic embolization), endovascular hemostasis was ineffective and required subsequent surgical intervention. CONCLUSION: Conclusions: Endovascular interventions are an effective method of diagnosis and treatment of postoperative abdominal bleeding. Prophylactic embolization allows you to prevent the recurrence of postoperative bleeding with an instrumentally undiagnosed source, however, you need to be prepared for the multi-stage treatment aimed at sequentially shutting down the collateral blood supply to the damaged area.

FINE-NEEDLE ANGIOGRAPHY IN CHRONIC LIMB-THREATENING ISCHEMIA DIABETIC PATIENTS.

OBJECTIVE: The aim: The features and efficiency of performing fine-needle angiography for Chronic Limb-Threatening Ischemia (CLTI) in Diabetic Patients diagnosis. PATIENTS AND METHODS: Materials and methods: From 2015-2020, a total of 180 angiography procedures were performed in below-the-knee (BTK) arterial disease diabetic patients with CLTI (Rutherford category 4 to 6). Relative contraindications such as severe heart failure, myocardial infarction (MI), arterial hypertension, impaired renal function, allergy to contrast media and intolerance to antiplatelet therapy we carefully evaluated and compared with the major amputation risks. Patients were selected with adequate inflow to the common and popliteal arterys, as defined by presence of normal ipsilateral femoral and popliteal pulse, biphasic or triphasic Doppler waveform. Ultrasound controlled fine-needle angiography, by retrograde puncture of the superficial femoral artery (SFA) was performed with an 18G-70mm angiographic needle in 96 patients (1st group). Antegrade angiography using femoral sheath in 84 patients (2nd group). RESULTS: Results: We have obtained adequate visualization BTK vessels by administering "Omnipak 300" 70% solution 9 mL with a power injector at a 3 mL/sec rate through the needle. Through the sidearm of the femoral sheath a total of contrast 15 mL, administered at 5 mL/sec rate. Fine-needle angiography 2.16 times reduces the injected contrast amount in patients. The hemorrhagic events frequency in the 1st group was significantly lower. CONCLUSION: Conclusions: Fine-needle angiography is recommended for CLTI Diabetic Patients diagnosis.

PERCUTANEOUS TRANSLUMINAL ROTARY ATHERECTOMY IN PATIENTS WITH ATHEROSCLEROTIC LESIONS OF BELOW THE KNEE ARTERIES.

OBJECTIVE: The aim: To determine the effectiveness of the combination of the percutaneous transluminal rotational atherectomy (PTRA) techniques with plain old balloon angioplasty (POBA) and POBA monotherapy (POBA-mono) in endovascular treatment (ET) of patients with occlusive-stenotic lesions below the knee (BTK) arteries. PATIENTS AND METHODS: Materials and methods: We studied two groups, the main included patients (n=9) aged who underwent PTRA and POBA of BTK arteries, and the comparative group (POBA-mono) of patients (n=24) who underwent POBA monotherapy of BTK arteries. RESULTS: Results: Thrombosis of the reconstructed segments in the target arteries after 12 months was diagnosed in 95% of patients of the control and 1 - main groups (Ft, p=0.00001). Healing of trophic ulcers of the foot in the first month after ET was observed in 78% (n=7) of patients of the main group and in 13% (n=3) of the control group (χ2 (1, n=33) = 10.2961; p=0.0013), and after 3 months - in 100% (n=9) and 83% (n=20) of patients in the respective groups. CONCLUSION: Conclusions: The combination of PTRA with POBA reduces the probability of repeated violations of the patency of the target artery. In addition, it increases the healing efficiency of trophic ulcers of the LE compared to POBA monotherapy.