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1.
Spinal Cord ; 55(6): 618-623, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28418395

RESUMO

STUDY DESIGN: Retrospective analysis of a prospective registry and surgeon survey. OBJECTIVES: To identify surgeon opinion on ideal practice regarding the timing of decompression/stabilization for spinal cord injury and actual practice. Discrepancies in surgical timing and barriers to ideal timing of surgery were explored. SETTING: Canada. METHODS: Patients from the Rick Hansen Spinal Cord Registry (RHSCIR, 2004-2014) were reviewed to determine actual timing of surgical management. Following data collection, a survey was distributed to Canadian surgeons, asking for perceived to be the optimal and actual timings of surgery. Discrepancies between actual data and surgeon survey responses were then compared using χ2 tests and logistic regression. RESULTS: The majority of injury patterns identified in the registry were treated operatively. ASIA Impairment Scale (AIS) C/D injuries were treated surgically less frequently in the RHSCIR data and surgeon survey (odds ratio (OR)= 0.39 and 0.26). Significant disparities between what surgeons identified as ideal, actual current practice and RHSCIR data were demonstrated. A great majority of surgeons (93.0%) believed surgery under 24 h was ideal for cervical AIS A/B injuries and 91.0% for thoracic AIS A/B/C/D injuries. Definitive surgical management within 24 h was actually accomplished in 39.0% of cervical and 45.0% of thoracic cases. CONCLUSION: Ideal surgical timing for traumatic spinal cord injury (tSCI) within 24 h of injury was identified, but not accomplished. Discrepancies between the opinions on the optimal and actual timing of surgery in tSCI patients suggest the need for strategies for knowledge translation and reduction of administrative barriers to early surgery.


Assuntos
Procedimentos Neurocirúrgicos , Traumatismos da Medula Espinal/epidemiologia , Traumatismos da Medula Espinal/cirurgia , Tempo para o Tratamento , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Canadá/epidemiologia , Vértebras Cervicais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurocirurgiões , Estudos Prospectivos , Sistema de Registros , Estudos Retrospectivos , Inquéritos e Questionários , Vértebras Torácicas , Adulto Jovem
2.
Spinal Cord ; 50(1): 22-7, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22042297

RESUMO

STUDY DESIGN: Development of a prospective patient registry. OBJECTIVE: To develop a patient registry for persons with traumatic spinal cord injuries (SCI), which can be used to answer research questions and improve patient outcomes. SETTING: Nine provinces in Canada. METHODS: The Rick Hansen Spinal Cord Injury Registry (RHSCIR) is part of the Translational Research Program of the Rick Hansen Institute. The launch of RHSCIR in 2004 heralded the initiation of the first nation-wide SCI patient registry within Canada. Currently, RHSCIR is being implemented in 14 cities located in 9 provinces, and there are over 1500 individuals who have sustained an acute traumatic SCI registered to date. Data are captured from the pre-hospital, acute and rehabilitation phases of care, and participants are followed in the community at 1, 2, 5 and then every 5 years post-injury. RESULTS: During the development of RHSCIR, there were many challenges that were overcome in selecting data elements, establishing the governance structure, and creating a patient privacy and confidentiality framework across multiple provincial jurisdictions. The benefits of implementing a national registry are now being realized. The collection of an internationally standardized set of clinical information is helping inform clinicians of beneficial interventions and encouraging a shift towards evidence-based practices. Furthermore, through RHSCIR, a network is forming amongst SCI clinicians and researchers, which is fostering new collaborations and the launch of multi-center clinical trials. CONCLUSIONS: For networks that are establishing SCI registries, the experiences and lessons learned in the development of RHSCIR may provide useful insights and guidance.


Assuntos
Bases de Dados Factuais/normas , Sistema de Registros/normas , Traumatismos da Medula Espinal/epidemiologia , Traumatismos da Medula Espinal/terapia , Canadá/epidemiologia , Ensaios Clínicos como Assunto/métodos , Medicina Baseada em Evidências/métodos , Medicina Baseada em Evidências/tendências , Humanos , Estudos Longitudinais/métodos , Estudos Longitudinais/tendências , Avaliação de Resultados em Cuidados de Saúde/métodos , Avaliação de Resultados em Cuidados de Saúde/tendências , Estudos Prospectivos , Traumatismos da Medula Espinal/diagnóstico
3.
J Orthop Trauma ; 20(8): 567-72, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16990729

RESUMO

BACKGROUND: Although numerous systems have been proposed, there is no universally accepted classification or scoring system for thoracolumbar spine injuries. Some have gained popularity, but most systems have never been modified or advanced beyond their initial introductory state. To the authors' knowledge, no thoracolumbar classification system has ever been validated in a systematic and scientific manner. STUDY PURPOSE: To critically review previous thoracolumbar classification systems, to discuss the proposal of the new Thoracolumbar Injury Classification and Severity Score (TLICS), to review the steps taken thus far in assessing the reliability of this system, and to discuss plans for future clinical validation of TLICS. METHODS: The authors performed a comprehensive search and analysis of previously published systems for classifying or scoring thoracolumbar spine injuries. Based on the merits and faults of these systems, among other factors, they have developed TLICS. CONCLUSIONS: Of the three phases of validating a fracture classification system described by Audige et al, TLICS has successfully passed through phase 1 (development) and phase 2 (multicenter agreement studies). With modifications made in response to phase 2 studies, TLICS will be ready to enter into the clinical validation phase. Although TLICS will initially be assessed for its ability to predict type of treatment, it is the authors' hope that, with appropriate analysis, the system will also be predictive of injury severity and clinical outcomes. These qualities remain to be demonstrated through rigorous prospective clinical investigation.


Assuntos
Escala de Gravidade do Ferimento , Traumatismos da Coluna Vertebral/classificação , Humanos , Vértebras Lombares , Vértebras Torácicas
4.
Can J Neurol Sci ; 29(3): 236-9, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12195612

RESUMO

OBJECTIVE: To determine the practice patterns for methylprednisolone administration for patients with acute spinal cord injury (SCI) within the spinal surgery community across Canada, and the reasons behind these patterns. METHODS: Canadian neurological and orthopedic spine surgeons were surveyed at their respective annual meetings with a questionnaire asking seven questions with respect to their practice standards. RESULTS: Sixty surgeons completed the survey representing approximately two-thirds of surgeons treating acute SCI within Canada. The NASCIS III dosing regimen is the most commonly prescribed steroid protocol. However, one-quarter of surgeons do not administer steroids at all. Of those who administer methylprednisolone, most do so because of peer pressure or out of fear of litigation. CONCLUSIONS: The vast majority of spine surgeons in Canada either do not prescribe methylprednisolone for acute SCI, or do so for what might be considered the wrong reasons. These results demonstrate the need for an evidence-based practice guideline. The Canadian Spine Society and the Canadian Neurosurgical Society fully endorse the recommendations of the steroid task force (see preceding paper).


Assuntos
Anti-Inflamatórios/uso terapêutico , Prescrições de Medicamentos/normas , Metilprednisolona/uso terapêutico , Traumatismos da Medula Espinal/tratamento farmacológico , Doença Aguda , Canadá , Humanos , Guias de Prática Clínica como Assunto/normas , Inquéritos e Questionários
5.
J Neurosurg ; 95(2 Suppl): 239-42, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11599844

RESUMO

Transoral decompression of the cervicomedullary junction may be compromised by a narrow corridor in which surgery is performed, and thus the adequacy of surgical decompression/resection may be difficult to determine. This is problematic as the presence of spinal instrumentation may obscure the accuracy of postoperative radiological assessment, or the patient may require reoperation. The authors describe three patients in whom high-field intraoperative magnetic resonance (MR) images were acquired at various stages during the transoral resection of C-2 disease that had caused craniocervical junction compression. All three patients harbored different lesions involving the cervicomedullary junction: one each of plasmacytoma and metastatic breast carcinoma involving the odontoid process and C-2 vertebral body, and basilar invagination with a Chiari I malformation. All patients presented with progressive myelopathy. Surgical planning MR imaging studies performed after the induction of anesthesia demonstrated the lesion and its relationship to the planned surgical corridor. Transoral exposure was achieved through placement of a Crockard retractor system. In one case the soft palate was divided. Interdissection MR imaging revealed that adequate decompression had been achieved in all cases. The two patients with carcinoma required placement of posterior instrumentation for stabilization. Planned suboccipital decompression and placement of instrumentation were averted in the third case as the intraoperative MR images demonstrated that excellent decompression had been achieved. Intraoperatively acquired MR images were instrumental in determining the adequacy of the decompressive surgery. In one of the three cases, examination of the images led the authors to change the planned surgical procedure. Importantly, the acquisition of intraoperative MR images did not adversely affect operating time or neurosurgical techniques, including instrumentation requirements.


Assuntos
Vértebra Cervical Áxis/cirurgia , Descompressão Cirúrgica/métodos , Imageamento por Ressonância Magnética , Idoso , Idoso de 80 Anos ou mais , Malformação de Arnold-Chiari , Neoplasias da Mama/patologia , Humanos , Pessoa de Meia-Idade , Monitorização Intraoperatória , Plasmocitoma/secundário , Plasmocitoma/cirurgia
6.
Clin Neuropharmacol ; 24(5): 254-64, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11586110

RESUMO

Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound influences on modern society from physical, psychosocial, and socioeconomic perspectives. Accordingly, the present decade has been labeled the Decade of the Spine to emphasize the importance of SCI and other spinal disorders. Spinal cord injury may be divided into both primary and secondary mechanisms of injury. The primary injury, in large part, determines a given patient's neurologic grade on admission and thereby is the strongest prognostic indicator. However, secondary mechanisms of injury can exacerbate damage and limit restorative processes, and hence, contribute to overall morbidity and mortality. A burgeoning body of evidence has facilitated our understanding of these secondary mechanisms of injury that are amenable to pharmacological interventions, unlike the primary injury itself. Secondary mechanisms of injury encompass an array of perturbances and include neurogenic shock, vascular insults such as hemorrhage and ischemia-reperfusion, excitotoxicity, calcium-mediated secondary injury and fluid-electrolyte disturbances, immunologic injury, apoptosis, disturbances in mitochondrion function, and other miscellaneous processes. Comprehension of secondary mechanisms of injury serves as a basis for the development and application of targeted pharmacological strategies to confer neuroprotection and restoration while mitigating ongoing neural injury. The first article in this series will comprehensively review the pathophysiology of SCI while emphasizing those mechanisms for which pharmacologic therapy has been developed, and the second article reviews the pharmacologic interventions for SCI.


Assuntos
Traumatismos da Medula Espinal/fisiopatologia , Doença Aguda , Animais , Apoptose , Morte Celular , Hemorragia/patologia , Hemorragia/fisiopatologia , Humanos , Isquemia/patologia , Isquemia/fisiopatologia , Traumatismos da Medula Espinal/patologia
7.
Clin Neuropharmacol ; 24(5): 265-79, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11586111

RESUMO

Spinal cord injury (SCI) remains a common and devastating problem of modern society. Through an understanding of underlying pathophysiologic mechanisms involved in the evolution of SCI, treatments aimed at ameliorating neural damage may be developed. The possible pharmacologic treatments for acute spinal cord injury are herein reviewed. Myriad treatment modalities, including corticosteroids, 21-aminosteroids, opioid receptor antagonists, gangliosides, thyrotropin-releasing hormone (TRH) and TRH analogs, antioxidants and free radical scavengers, calcium channel blockers, magnesium replacement therapy, sodium channel blockers, N -methyl-D-aspartate receptor antagonists, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-kainate receptor antagonists, modulators of arachadonic acid metabolism, neurotrophic growth factors, serotonin antagonists, antibodies against inhibitors of axonal regeneration, potassium channel blockers (4-aminopyridine), paclitaxel, clenbuterol, progesterone, gabexate mesylate, activated protein C, caspase inhibitors, tacrolimus, antibodies against adhesion molecules, and other immunomodulatory therapy have been studied to date. Although most of these agents have shown promise, only one agent, methylprednisolone, has been shown to provide benefit in large clinical trials. Given these data, many individuals consider methylprednisolone to be the standard of care for the treatment of acute SCI. However, this has not been established definitively, and questions pertaining to methodology have emerged regarding the National Acute Spinal Cord Injury Study trials that provided these conclusions. Additionally, the clinical significance (in contrast to statistical significance) of recovery after methylprednisolone treatment is unclear and must be considered in light of the potential adverse effects of such treatment. This first decade of the new millennium, now touted as the Decade of the Spine, will hopefully witness the emergence of universal and efficacious pharmacologic therapy and ultimately a cure for SCI.


Assuntos
Tratamento Farmacológico/métodos , Traumatismos da Medula Espinal/tratamento farmacológico , Doença Aguda , Animais , Ensaios Clínicos como Assunto/métodos , Ensaios Clínicos como Assunto/estatística & dados numéricos , Humanos
8.
Can J Neurol Sci ; 28(2): 125-9, 2001 May.
Artigo em Inglês | MEDLINE | ID: mdl-11383936

RESUMO

BACKGROUND: The optimal surgical treatment of atlanto-axial instability remains controversial despite the variety of modifications and supplemental techniques currently available. METHODS: We describe a modification of the Brooks posterior wiring technique supplemented with transarticular screws for C1-C2 instability. RESULTS: This method has been implemented in 30 patients in our institution with no radiological failures. CONCLUSIONS: The modification provides several technical advantages and potentially stronger fixation compared to methods currently in use.


Assuntos
Vértebra Cervical Áxis/cirurgia , Atlas Cervical/cirurgia , Instabilidade Articular/cirurgia , Fusão Vertebral/métodos , Fios Ortopédicos , Humanos , Fusão Vertebral/instrumentação
10.
Spine (Phila Pa 1976) ; 26(24 Suppl): S39-46, 2001 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-11805608

RESUMO

STUDY DESIGN: Literature review. OBJECTIVES: The purpose of this article is to review the available literature and formulate evidence-based recommendations for the use of methylprednisone in the setting of acute spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: Since the early 1990s, methylprednisolone has become widely prescribed for the treatment of acute SCI. Arguably, it has become a standard of care. METHODS: Through an electronic database search strategy and by cross-reference with published literature, appropriate clinical studies were identified. They were reviewed in chronologic order with respect to study design, outcome measures, results, and conclusions. RESULTS: Nine studies were identified that attempted to evaluate the role of steroids in nonpenetrating (blunt) spinal cord injury. Five of these were Class I clinical trials, and four were Class II studies. All of the studies failed to demonstrate improvement because of steroid administration in any of the a priori hypotheses testing. Although post hoc analyses were interesting, they failed to demonstrate consistent significant treatment effects. CONCLUSIONS: From an evidence-based approach, methylprednisolone cannot be recommended for routine use in acute nonpenetrating SCI. Prolonged administration of high-dose steroids (48 hours) may be harmful to the patient. Until more evidence is forthcoming, methylprednisolone should be considered to have investigational (unproven) status only.


Assuntos
Medicina Baseada em Evidências , Metilprednisolona/uso terapêutico , Fármacos Neuroprotetores/uso terapêutico , Traumatismos da Medula Espinal/tratamento farmacológico , Ferimentos não Penetrantes/tratamento farmacológico , Doença Aguda , Humanos , Metilprednisolona/efeitos adversos , Fármacos Neuroprotetores/efeitos adversos
11.
Neurosurg Focus ; 10(2): E4, 2001 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-16749751

RESUMO

OBJECT: Because transoral decompression of the cervicomedullary junction is compromised by a narrow surgical corridor, the adequacy of decompression/resection may be difficult to determine. This is problematic as spinal hardware may obscure postoperative radiological assessment, or the patient may require reoperation. The authors report three patients in whom high-field intraoperative magnetic resonance (MR) images were acquired at various stages during the transoral resection of C-2 lesions causing craniocervical junction compression. METHODS: In all three patients the lesions involved the cervicomedullary junction: one case each of plasmacytoma and metastatic breast carcinoma involving the odontoid process and C-2 vertebral body, and one case of basilar invagination with a Chiari type I malformation. All three patients presented with progressive myelopathy. Surgery-planning MR imaging studies, performed after the induction of anesthesia, demonstrated the lesion and its relationship to the planned surgical corridor. Transoral exposure was achieved through placement of a Crockard retractor system. In one case the soft palate was divided. Interdissection MR imaging revealed that adequate decompression had been achieved in all cases. In the two patients with carcinoma, posterior instrumentation was placed to achieve spinal stabilization. Planned suboccipital decompression and fixation was averted in the third case because MR imaging demonstrated that excellent decompression had been achieved. CONCLUSIONS: Intraoperatively acquired MR images were instrumental in determining the adequacy of surgical decompression. In one patient the MR images changed the planned surgical procedure. Importantly, the acquisition of intraoperative MR images did not adversely affect operative time or neurosurgical techniques, including the instrumentation procedure.


Assuntos
Malformação de Arnold-Chiari/cirurgia , Descompressão Cirúrgica/métodos , Plasmocitoma/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/patologia , Vértebras Cervicais/patologia , Vértebras Cervicais/cirurgia , Humanos , Período Intraoperatório , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Boca/cirurgia , Neoplasias da Coluna Vertebral/secundário
12.
Can J Neurol Sci ; 27(4): 297-301, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11097519

RESUMO

BACKGROUND: Traditionally, odontoid fractures have been treated with different bracing techniques resulting in variable degrees of successful healing. Surgical intervention is becoming more widely practiced as a primary intervention. The purpose of this report was to survey our recent experience in southern Alberta to determine potential outcome differences in management strategies. METHODS: We retrospectively reviewed the charts of 520 patients diagnosed with cervical spine fractures over a six-year period from January 1990, through December 1996. Patients were identified through the medical records database of the two Level 1 trauma facilities, on the basis of ICD-9 diagnostic coding. RESULTS: Ninety-three fractures of the odontoid process were identified, of which 85 were acute and eight were chronic. There were 57 Type II (67%) and 27 Type III (32%) acute odontoid fractures. Of these, 64 were managed conservatively (bracing), whereas 20 were treated surgically. Thirteen patients underwent anterior screw fixation, seven patients had posterior cervical fusion. Eleven patients died in the acute phase, two as a result of their high cervical cord injury and nine from unrelated medical causes. Fifty-six of the remaining 82 patients (68%) were located with a minimum of three months follow-up (range three months to eight years). Satisfactory results were obtained in 76% of all acute patients treated by bracing, but only 50% in those over the age of 65. In the surgically managed group, all patients (100%) went on to develop stable fusions. CONCLUSIONS: Our results indicate that while conservative management of odontoid fractures with external bracing results in fracture healing in most cases, surgical fusion may provide superior rates of bony union with acceptable morbidity. This difference in outcome lends itself to formal investigation through a prospective randomized trial.


Assuntos
Fixadores Externos , Processo Odontoide/cirurgia , Fraturas da Coluna Vertebral/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Vértebras Cervicais/lesões , Vértebras Cervicais/cirurgia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Processo Odontoide/lesões , Estudos Retrospectivos , Fusão Vertebral/métodos
13.
J Pharmacol Toxicol Methods ; 43(1): 31-9, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11091128

RESUMO

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is ubiquitous in contemporary medical practice and these agents are efficacious in a number of clinical contexts. In particular, NSAIDs have proven to be highly effective adjuncts in the amelioration of postoperative pain in the subset of patients undergoing spinal surgery requiring fusion. NSAIDs act through inhibition of cyclooxygenase enzymes and therefore diminish prostaglandin production. However, prostaglandins are intimately involved in the modulation of bone metabolism and the balance of data, from both clinical and laboratory contexts, indicate that prostaglandins preferentially favor bone anabolism. Most recently, limited emerging evidence suggests that NSAID administration in patients undergoing spinal fusion surgery may increase nonunion rates, which in turn, has important ramifications to the patient, their family and the entire medical system. Hence, disparate views have evolved regarding the use of NSAIDs in postoperative pain control in patients undergoing spinal surgery requiring fusion. NSAIDs have proven efficacy in the management of postoperative pain in these patients, however, this must be weighed against the risk of nonunion and its associated consequences. In this review, the role of prostaglandins in bone metabolism, the pharmacology of NSAIDs and the modulation of bone metabolism by NSAIDs are discussed. Additionally, the current evidence examining the use of NSAIDs in spinal surgery is presented. As rates of spinal surgery continue to rise, it is imperative that the apparent pharmacological quandary surrounding the administration of NSAIDs in patients undergoing spinal surgery requiring fusion be addressed, both to guide present clinical practice and to outline further directions for investigation.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Osso e Ossos/metabolismo , Fusão Vertebral , Animais , Osso e Ossos/efeitos dos fármacos , Contraindicações , Inibidores de Ciclo-Oxigenase/uso terapêutico , Humanos , Dor Pós-Operatória/tratamento farmacológico , Prostaglandinas/biossíntese , Prostaglandinas/metabolismo
14.
J Neurosurg ; 93(1 Suppl): 1-7, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10879751

RESUMO

OBJECT: Since publication in 1990, results from the National Acute Spinal Cord Injury Study II (NASCIS II) trial have changed the way patients suffering an acute spinal cord injury (SCI) are treated. More recently, recommendations from NASCIS III are being adopted by institutions around the world. The purpose of this paper is to reevaluate carefully the results and conclusions of these studies to determine the role they should play in influencing decisions about care of the acutely spinal cord-injured patient. METHODS: Published results from NASCIS II and III were reviewed in the context of the original study design, including primary outcomes compared with post-hoc comparisons. Data were retroconverted from tabular form back to raw form to allow direct inspection of changes in treatment groups. These findings were further analyzed with respect to justification of practice standards. Although well-designed and well-executed, both NASCIS II and III failed to demonstrate improvement in primary outcome measures as a result of the administration of methylprednisolone. Post-hoc comparisons, although interesting, did not provide compelling data to establish a new standard of care in the treatment of patients with acute SCI. CONCLUSIONS: The use of methylprednisolone administration in the treatment of acute SCI is not proven as a standard of care, nor can it be considered a recommended treatment. Evidence of the drug's efficacy and impact is weak and may only represent random events. In the strictest sense, 24-hour administration of methylprednisolone must still be considered experimental for use in clinical SCI. Forty-eight-hour therapy is not recommended. These conclusions are important to consider in the design of future trials and in the medicolegal arena.


Assuntos
Metilprednisolona/uso terapêutico , Fármacos Neuroprotetores/uso terapêutico , Traumatismos da Medula Espinal/tratamento farmacológico , Doença Aguda , Tomada de Decisões , Seguimentos , Humanos , Metilprednisolona/efeitos adversos , Atividade Motora/fisiologia , Fármacos Neuroprotetores/efeitos adversos , Dor/fisiopatologia , Guias de Prática Clínica como Assunto , Pressão , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Reprodutibilidade dos Testes , Projetos de Pesquisa , Tato/fisiologia , Resultado do Tratamento
16.
Spine (Phila Pa 1976) ; 24(18): 1894-902, 1999 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-10515013

RESUMO

STUDY DESIGN: An in vitro study compared the biomechanics of the upper cervical spine among three groups of cadaveric specimens, each with a different source of instability: transverse-alar-apical ligament disruptions, odontoid fractures, or odontoidectomies. The responses of the three groups were again compared after a uniform posterior cable and graft fixation was applied to the specimens. OBJECTIVES: To quantify and compare the effects of different injuries on atlantoaxial stability and to determine whether a single fixation technique effectively treats each injury. SUMMARY OF BACKGROUND DATA: Previous biomechanical studies of atlantoaxial instability have been focused on mechanisms of injury or on comparison among fixation types. METHODS: Cables and pulleys applied torques to human cadaveric C0-C6 specimens quasistatically while an optical system tracked three-dimensional angular and translational motion at C0-C1 and C1-C2. Specimens were tested immediately after injury, after posterior cable and graft fixation, and after 6000 cycles of fatigue. RESULTS: Odontoidectomies increased C1-C2 angular and translational range of motion significantly more than odontoid fractures or ligament disruptions, especially during flexion-extension. Odontoid fractures produced a slightly larger increase in C1-C2 angular range of motion than ligament disruptions but a smaller increase in C0-C1 range of motion. The different injuries affected the lax zone and the position of C1-C2 axis of rotation differently. Restabilization by posterior cable and graft reduced motion only moderately for each injury type. All three fixated injuries were susceptible to loosening from fatigue. CONCLUSION: The three different injuries produce different spinal biomechanical responses. To best promote fusion, posterior cable and graft fixation should be used with an adjunctive stabilizing technique to treat all three injuries.


Assuntos
Articulação Atlantoaxial/fisiopatologia , Fios Ortopédicos , Vértebras Cervicais/fisiopatologia , Traumatismos da Coluna Vertebral/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Articulação Atlantoaxial/cirurgia , Vértebras Cervicais/lesões , Feminino , Fraturas de Estresse/fisiopatologia , Humanos , Técnicas In Vitro , Instabilidade Articular/fisiopatologia , Instabilidade Articular/cirurgia , Ligamentos Articulares/lesões , Ligamentos Articulares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Processo Odontoide/lesões , Processo Odontoide/fisiopatologia , Processo Odontoide/cirurgia , Amplitude de Movimento Articular/fisiologia , Rotação , Traumatismos da Coluna Vertebral/cirurgia , Estresse Mecânico
17.
J Neurosurg ; 90(1 Suppl): 84-90, 1999 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10413131

RESUMO

OBJECT: The purpose of this study was to compare cable techniques used in occipitocervical fixation with two types of screw fixation. The authors hypothesized that screw fixation would provide superior immobilization compared with cable methods. METHODS: Ten cadaveric specimens were prepared for biomechanical analyses by using standard techniques. Angular and linear displacement data were recorded from the occiput to C-6 with infrared optical sensors after conditioning runs. Specimens underwent retesting after fatiguing. Six methods of fixation were analyzed: Steinmann pin with and without C-1 incorporation; Cotrel-Dubousett horseshoe with and without C-1 incorporation; Mayfield loop with C1-2 transarticular screw fixation; and a custom-designed occipitocervical transarticular screw-plate system. Sublaminar techniques were extended to include C-3 in the fusion construct, whereas transarticular techniques incorporated the occiput, C-1, and C-2 only. All methods of fixation provided significant immobilization in all specimens compared with the nonconstrained destabilized state. Despite incorporation of an additional vertebral segment, sublaminar techniques performed worse as a function of applied load than screw fixation techniques. Following fatiguing, these differences were more pronounced. The sublaminar techniques failed most prominently in flexion-extension and in axial rotation. On gross inspection, increased angular displacement associated with loosening of the sublaminar cables was observed. CONCLUSION: Occipitocervical fixation can be performed using a variety of techniques; all bestow significant immobilization compared with the destabilized spine. All methods tested in this study were susceptible to fatigue and loss of reduction and were weakest in resisting vertical settling. Screw fixation of the occiput-C2 reduces the number of vertebral segments that are necessary to incorporate into the fusion construct while providing superior immobilization and resistance to fatigue and vertical settling compared with sublaminar methods.


Assuntos
Articulação Atlantoccipital/cirurgia , Parafusos Ósseos , Fios Ortopédicos , Vértebras Cervicais/cirurgia , Instabilidade Articular/cirurgia , Osso Occipital/cirurgia , Análise de Variância , Fenômenos Biomecânicos , Cadáver , Humanos , Resultado do Tratamento
18.
J Neurosurg ; 90(2 Suppl): 191-7, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10199248

RESUMO

OBJECT: Pain control can often be improved by local (as opposed to systemic) application of analgesic and/or anesthetic medication. The purpose of this study was to evaluate the efficacy of a single-dose epidural analgesic "paste" in the control of postoperative pain in patients who have undergone lumbar decompressive surgery. METHODS: Sixty patients undergoing routine elective lumbar decompressive surgery were randomized in a double-blind fashion to one of two groups: those receiving active paste or placebo paste. The paste was applied to the exposed dura at the time of surgery, just prior to wound closure. Patients received follow-up care in the hospital and at home for 3 months postsurgery. Several outcome measures were studied to ascertain differences in pain control and to ensure comparability between groups. Patients who received active paste demonstrated significantly lower pain scores compared with those who received placebo paste for up to 6 weeks postoperatively. General health perception indexed by the Short Form 36 was also significantly better in patients who received active paste for up to 6 weeks. In-hospital and outpatient oral narcotic consumption was significantly lower in the active paste-treated group. Inpatient straight leg raising scores were improved in those patients who received active compared with control paste. CONCLUSIONS: Application of an analgesic paste directly to the epidural space during lumbar decompressive surgery significantly improves postoperative pain control, reduces prescribed analgesic drug consumption, and improves overall health perception for up to 6 weeks following surgery. The authors conclude that this postoperative pain control strategy is both effective and safe and may provide a new standard of pain management in patients undergoing lumbar discectomy or laminectomy.


Assuntos
Analgesia Epidural/métodos , Descompressão Cirúrgica , Vértebras Lombares/cirurgia , Analgesia Epidural/normas , Discotomia , Método Duplo-Cego , Estudos de Avaliação como Assunto , Feminino , Humanos , Laminectomia , Masculino , Pessoa de Meia-Idade , Pomadas , Cuidados Paliativos/normas , Complicações Pós-Operatórias , Estudos Prospectivos , Resultado do Tratamento
19.
J Neurosurg ; 89(1): 133-8, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9647184

RESUMO

This 44-year-old man presented with a 4-year history of progressive spastic weakness of his legs. He was found to have epidural lipomatosis behind the thoracic spinal cord, and the nerve roots exited from the posterior and anterior midline planes of the dura, indicating a 90 degree rotation of the thoracic cord. Magnetic resonance images clearly demonstrated the segmental thoracic nerve roots exiting from the dorsal midline of the dura, a finding confirmed at surgery. The authors found only one previously published case of rotation of the spinal cord. Directed mechanical stress caused by deformation of the rotated spinal cord, rather than compression from adipose tissue, is proposed as the mechanism of the myelopathy. The extent, location, and thickness of the associated extradural adipose tissue is suggestive of epidural lipomatosis. The lipomatous tissue might have been an epiphenomenon and cord rotation an isolated congenital anomaly. Alternatively, asymmetrical growth of epidural fat may have exerted torque, rotating the thecal sac.


Assuntos
Doenças da Medula Espinal/diagnóstico , Tecido Adiposo/patologia , Adulto , Espaço Epidural , Seguimentos , Humanos , Perna (Membro) , Lipomatose/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Debilidade Muscular/diagnóstico , Doenças do Sistema Nervoso Periférico/diagnóstico , Rotação , Espasmo/diagnóstico , Raízes Nervosas Espinhais/patologia , Estresse Mecânico , Vértebras Torácicas
20.
Can J Anaesth ; 45(2): 170-4, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9512854

RESUMO

PURPOSE: To report the successful perioperative anaesthetic and analgesic management of a spinal trauma patient with a surgically placed epidural catheter. CLINICAL FEATURES: A 15-yr-old adolescent woman sustained an unstable spinal column injury with an incomplete neurological deficit following a high speed motor vehicle accident. She was scheduled for spinal decompression and stabilisation through a left thoracoabdominal approach. Balanced general anaesthesia was undertaken. Prior to closure, a multi-orifice epidural catheter was surgically placed under direct vision 5 cm into the anterior epidural space. The catheter was then tunnelled out through the psoas muscle and secured in place. Combined epidural-general anaesthesia was then initiated for the duration of the case using 5 ml bupivacaine 0.25% after an initial test dose of 3 ml lidocaine 1.5% with epinephrine. An infusion of bupivacaine 0.10% and fentanyl 5 micrograms.ml-1 at 8 ml.hr-1 using patient controlled epidural analgesia (PCEA) provided excellent postoperative pain control for four days. She had an uncomplicated postoperative course. CONCLUSION: A surgically placed epidural catheter provided excellent, safe, perioperative anaesthesia and analgesia in this patient with unstable spinal trauma.


Assuntos
Analgesia Epidural/métodos , Anestesia Epidural/métodos , Cateterismo/métodos , Dor/tratamento farmacológico , Compressão da Medula Espinal/complicações , Acidentes de Trânsito , Adolescente , Anestesia Geral , Anestésicos Locais/administração & dosagem , Anestésicos Locais/uso terapêutico , Bupivacaína/administração & dosagem , Bupivacaína/uso terapêutico , Cateterismo/instrumentação , Feminino , Humanos , Lidocaína/administração & dosagem , Lidocaína/uso terapêutico , Dor Pós-Operatória/tratamento farmacológico , Compressão da Medula Espinal/cirurgia
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