RESUMO
OBJECTIVE: Aim: The goal is to discover QSAR of Lomefloxacin as antibacterial activity. PATIENTS AND METHODS: Materials and Methods: A number of lomefloxacins analogs activities were studied by program Windows Chem SW. The analogues were obtained and energy minimization was carried out through Molecular Modeling Program, the calculations were performed using General Atomic and Molecular Electronic Structure System (GAMESS) software. RESULTS: Results: There were six descriptions (N-quinoline more (-) ev charge, Kinetic Energy, Potential Energy, Log p, Log S, F6 charge) results have highly compatible of physicochemical properties with lomefloxacin analogs activities. It can be used to estimate the activities depending on QSAR equation of lomefloxacin analogs. CONCLUSION: Conclusions: The parameters used for calculation were depending on the quantum chemical was employed in deriving from computational study of properties and can used to predict the activities of certain analogs of Lomefloxacins as antibacterial compounds.
Assuntos
Fluoroquinolonas , Relação Quantitativa Estrutura-Atividade , Humanos , Fluoroquinolonas/farmacologia , Modelos Moleculares , Antibacterianos/farmacologiaRESUMO
BACKGROUND: Stevia rebaudiana Bertoni leaves are well-known for their sweetness and have been used as a non-caloric sweetener in several countries. It has numerous therapeutic properties which have been proven safe and effective over hundreds of years. In the present study, we aimed to evaluate the possible antioxidant effects of stevia extracts and their role in regulating AMPK in type-1 diabetic rats. METHODS: Fifty male Sprague Dawely rats were divided into: (1) normal control (NC) group; normal rats receiving 0.5 ml normal saline, (2) DM group; diabetic rats receiving 0.5 ml normal saline, (3) DM + MSE group; DM rats receiving 200 mg/kg of methanolic extract of stevia, (4) DM + S group; DM rats receiving 2 mg/kg of pure stevioside, and (5) DM + CGA group; DM rats receiving 10 mg/kg of pure chlorogenic acid. Four weeks after treatment, AMPK activity, GLUT4 mRNA and oxidative stress markers were measured in frozen muscles. Also, fasting blood glucose in serum, insulin and HbA1c were measured at the end of experiment. RESULTS: DM caused a significant increase in serum fasting glucose, HbA1c and muscle MDA with significant reduction in serum insulin, muscle SOD, catalase, GPx, AMPK activity and GLUT4 expression (p < 0.05). Treatment with stevia extract, pure stevioside and chlorogenic acid caused significant improvements in the studied parameters (p < 0.05). CONCLUSIONS: We concluded that stevia extracts and derivatives may improve metabolic dysfunction in skel- etal muscles via upregulation of AMPK and GLUT4 and suppression of oxidative stress.
Assuntos
Proteínas Quinases Ativadas por AMP/metabolismo , Antioxidantes/farmacologia , Diabetes Mellitus Tipo 1/metabolismo , Músculo Esquelético/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Stevia , Animais , Antioxidantes/metabolismo , Diabetes Mellitus Tipo 1/tratamento farmacológico , Transportador de Glucose Tipo 4/metabolismo , Masculino , Músculo Esquelético/metabolismo , Fitoterapia , Extratos Vegetais/uso terapêutico , Folhas de Planta , Ratos Sprague-Dawley , Regulação para CimaRESUMO
Leaves of Eugenia edulis contain the new polyoxygenated flavonoid derivatives, gossypetin-3,8-dimethyl ether-5-O-beta-glucoside; gossypetin-3,5-dimethyl ether, and myricetin-3,5,3'-trimethyl ether. In addition, ten known polyphenolics were also isolated and identified. All structures were established on the basis of chemical and spectral evidence, including ESI-MS and 13C NMR.
Assuntos
Flavonoides/química , Flavonoides/isolamento & purificação , Syzygium/química , Flavonoides/metabolismo , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Oxigênio/metabolismo , Fenóis/química , Fenóis/isolamento & purificação , Folhas de Planta/química , Folhas de Planta/metabolismo , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta , Syzygium/metabolismoRESUMO
The new natural caffeoyl esters, 3,6-di-O-caffeoyl-(alpha/beta)-glucose and 1-O-caffeoyl-beta-xylose, together with the hitherto unknown natural tannin, 2,3-O-hexahydroxydiphenoyl-4,6-O-sanguisorboyl-(alpha/beta)-glucose, have been isolated from the aqueous alcohol aerial part extract of Rubus sanctus. Establishment of all structures was based on the chemical and spectral evidence, including ESI-MS and 2D NMR.
Assuntos
Ácidos Cafeicos/química , Ésteres/química , Taninos Hidrolisáveis , Rosaceae/química , Taninos/química , Configuração de Carboidratos , Ésteres/isolamento & purificação , Glucose/análogos & derivados , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Plantas Medicinais/química , Espectrofotometria Ultravioleta , Taninos/isolamento & purificação , Xilose/análogos & derivadosRESUMO
Three acylated flavonol diglucosides, kaempferol 3-O-beta-(6"-O-E-p-coumaroylglucoside)-7-O-beta-glucoside; quercetin 3-O-beta-(6"-O-E-p-coumaroylglucoside)-7-O-beta-glucoside; isorhamnetin 3-O-beta-(6"-O-E-p-coumaroylglucoside)-7-O-beta-glucoside were isolated from the whole plant aqueous alcohol extract of Lotus polyphyllos. The known 3,7-di-O-glucosides of the aglycones kaempferol, quercetin and isorhamnetin were also characterized. All structures were established on the basis of chemical and spectral evidence.
