RESUMO
With the help of Integral-2MT cytoanalyzer, the average area of nuclei and the percentage of epitheliocytes with small, medium and large nuclei at the site of dysplasia of serous cysts and serous ovarian carcinomas have been evaluated. An increase in the degree of dysplasia of tumorous epithelium is associated with an increase in the average area of nuclei and the number of cells with medium nuclei. A decrease in the degree of differentiation of serous ovarian carcinomas is accompanied by increasing percentage of cells with large nuclei. Preoperative chemotherapy does not affect this regularity.
Assuntos
Cistadenoma Papilar/ultraestrutura , Cistadenoma Seroso/ultraestrutura , Cistos Ovarianos/ultraestrutura , Neoplasias Ovarianas/ultraestrutura , Biópsia , Diagnóstico Diferencial , Epitélio/ultraestrutura , Feminino , Humanos , Cariometria/instrumentação , Cariometria/estatística & dados numéricos , Ovário/ultraestrutura , PrognósticoRESUMO
Morphofunctional state of nucleolar organizers in epithelial cells of benign, and malignant serous ovarian tumours has been studied. A rise in the activity of nucleolar organizers depending upon an increase of the level of malignancy has been revealed.
Assuntos
Cistadenocarcinoma Seroso/ultraestrutura , Cistadenoma Papilar/ultraestrutura , Cistadenoma Seroso/ultraestrutura , Região Organizadora do Nucléolo/ultraestrutura , Neoplasias Ovarianas/ultraestrutura , Epitélio/ultraestrutura , Feminino , Humanos , Prognóstico , Coloração pela PrataRESUMO
Dynamic cytologic examinations of puncture biopsy specimens of ovarian carcinoma and of serous cavity fluid in metastases of the carcinoma over the course of chemotherapy help assess the treatment efficacy and timely correct it. Carcinoma metastases to the pleural and abdominal cavity are more sensitive to chemotherapy than the primary tumor. Chemotherapy efficacy improves if a greater number of courses of therapy are administered.