[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes]. / Prospektivnaia évoliutsiia kupiruiushchei terapii pri pristupakh mertsiatel'noi aritmii u bol'nykh s sindromom prezhdevremennogo vozbuzhdeniia zheludochkov.

A comparative study of antiarrhythmic drugs was performed in 81 patients with atrial fibrillation attacks in the presence of preexcitation syndrome. The first intravenous administration of cordarone was effective in 84.06%, disopyramide--in 69%, ajmaline in 44.8, verapamil in 42.1, novocaine amide in 39.4 and ethacizin in 38.5% of the patients. The first oral administration of quinidine and kinilentin arrested 80.4% of arrhythmia attacks, disopyramide 66.7% propranolol and mexitil 37.5 and 33.3%, respectively. Prospective evolution of antiarrhythmic therapy manifested with decreased therapeutic efficacy of the drugs from 55.7 to 26.2% in the whole group during the period of 1-5 years.

[The prospective evolution of the efficacy of antiarrhythmia therapy in paroxysmal supraventricular tachycardia in patients with the ventricular pre-excitation syndrome]. / Prospektivnaia évoliutsiia éffektivnosti antiaritmicheskoi terapii pri paroksizmal'noi nadzheludochkovoi takhikardii u bol'nykh s sindromom prezhdevremennogo vozbuzhdeniia zheludochkov.

Evolution of the effectiveness of antiarrhythmic drugs used in 240 patients with preexcitation syndrome to arrest episodes of paroxysmal supraventricular tachycardia was analysed prospectively. The first intravenous administration was effective in 97, 93.3, 80.9, 75, 70.3, 60, 48% of cases for novocainamid, verapamil, cordarone, disopyramide, ajmaline, ethacizine, mexitil and inderal, respectively. When observed in prospective evolution for 10-14 years, overall group efficacy dropped from 81.3% at first administration to 21.4%.

[Clinical aspects and diagnosis of klofelin poisoning]. / O klinike i diagnostike otravleniia klofelinom.

Examination of 15 patients with clofelin poisoning cleared up clinical symptoms of the condition. The impairment was chiefly inflicted to cardiovascular system and neuropsychic status. There appeared arterial hypotonia, long-term orthostatic hypotonia combined with bradycardia and extrasystolic arrhythmia. Early hours of poisoning can be accompanied with high pressure (hypertensive phase). ECG records sinus bradycardia and early ventricular repolarization. Neuropsychic alterations involve drowsiness, stupor++, psychic inhibition, visual and auditory hallucinations, photopsia. The condition was managed symptomatically. All the patients recovered.

[Pulmonary circulation in ischemic heart diseases under bicycle ergometer load and acute strophanthin test conditions (based on data from catheterization of the right heart and pulmonary artery)]. / Sostoianie malogokruga krovobrashcheniia u bol'nykh ishemicheskoi bolezn'iu serdtsa v usloviiakh veloérgometricheskoi nagruzki i ostroi strofantinovoi proby (po dannym kateterizatsii pravykh otdelov serdtsa i legochnoi arterii)

On the basis of monitoring the systolic, diastolic and mean pulmonary artery pressur at rest, during ergometric exercises and under identical conditions following premedicatio with cardiac glycosides (48 measurements in 12 patients with ischaemic heart disease) the authors concluded on the importance of studying this parameter for the diagnosis of initial stage cardiac insufficiency, and on its high informativeness for deciding the indications for initiating therapy with cardiac glycosides.

[Experimental and clinical data on the state of the atria in postinfarct cardiosclerosis]. / Eksperimental'nye i klinicheskie dannye o sostoianii predserdii pri postinfarktnom kardioskleroze

In 16 rabbit experiments with macrofocal postinfarction cardiosclerosis and 8 control intact animals delayed electron microscopy of myocardium portions from the left ventricle and atria was undertaken, and in 76 clinical observations of patients who had survived a myocardial infarction 1 to 10 years before the examination the indices of the haemodynamic and electrical activity of the atria were compared with those of the contractile function of the left ventricular myocardium under bicycle exercise tests of a growing intensity (with the data of the left ventricular ultrastructure--in the experimental cases). The changes in the left atrium were found to be of an adaptational nature, the right atrium entering the pathogenetic chain when the compensatory capacities of the left atrium got exhausted in the course of the disease, this being a prognostically alerting sign.

[Stimulators of beta-adrenergic structures in treatment of ischemic heart disease]. / Stimuliatory beta-adrenergicheskikh struktur v terapii bol'nykh ishemicheskoi bolezn'iu serdtsa

The beneficial effect of stimulators of beta-adrenergic structures (Myophedrin on the haemodynamics and the inotropic function of the myocardium was demonstrated experimentally (in 12 rabbits) and clinically (in 53 patients with ischaemic heart disease). A positive effect of the treatment was noted in 45.5% of those patients in whom ischaemic heart disease manifested itself in angina decubitus and angina of effort.