Update on the diagnosis and treatment of mirizzi syndrome in laparoscopic era: our experience in 7 years.

INTRODUCTION: Mirizzi syndrome (MS) is a rare complication of cholelithiasis. The objective of this study was to assess the current incidence of MS in our area and present our experience in the clinical, diagnostic, and therapeutic management, focussing in laparoscopic approach. MATERIALS AND METHODS: We prospectively analyzed 35 cases of MS between January 2006 and November 2012, collecting information regarding demographics, clinical management, diagnostic methods, surgical procedure, postoperative morbidity, and follow-up. All patients underwent abdominal ultrasonography. In patients with suspected obstructive jaundice, magnetic cholangiography resonance and endoscopic retrograde cholangiopancreatogram were performed preoperatively, detecting MS in 68.5% of patients. RESULTS: The incidence of MS was 2.8% in 1168 cholecystectomies for cholelithiasis. There were 13 men and 22 women, with a mean age of 70.1 years. Nineteen patients had MS type I (54.2%). Fourteen were treated with laparoscopic cholecystectomy (LC) successfully, whereas 3 conversions were performed because of difficult surgical dissection. In the remaining 2, subtotal cholecystectomy was performed. Seven patients had type II MS (20%). In 5 cases cholecystectomy and bile duct repair were performed with T-tube placement (in 4 by laparoscopic approach), in another one subtotal cholecystectomy with primary biliary choledochorrhaphy was performed, because of dilated bile duct. Finally, the remaining patients with type III and IV SM (14.2% and 11.4%, respectively) were treated with Roux-en-Y hepaticojejunostomy.We observed 14.5% morbidity, highlighting 2 cases of postoperative collection and 1 case of biliary fistula. There was no postoperative mortality. The mean follow-up of patients was 13.4±4 months. CONCLUSIONS: Preoperative diagnosis of MS is difficult, but it is essential in the proper management of the disease. Investigations as magnetic cholangiography resonance and endoscopic retrograde cholangiopancreatogram contribute to the success of preoperative identification. LC should be reserved to MS type I and type II highly selected cases. This pathology should be treated by experienced surgeons to decrease the risk of iatrogenia.

Laparoscopic cholecystectomy and liver cirrhosis.

INTRODUCTION: Historically the presence of liver cirrhosis has been an absolute or relative contraindication to laparoscopic cholecystectomy (LC). Accumulating experience in LC has resulted in an increasing number of investigators reporting that LC can be safely performed in cirrhotic patients. The aim of this study was to report the efficacy and safety of LC in the treatment of symptomatic cholelithiasis in cirrhotic patients, and a review of the literature in the matter. METHODS: Between January 2006 and July 2010, from 503 patients under LC, we reviewed 43 cirrhotic patients of Child-Pugh Classification A, B, and C, with symptomatic gallstones. RESULTS: Conversion to an open procedure was necessary in 5 patients due to multiple factors. The mean operative time and length of hospital stay were significantly longer and higher in cirrhotic group (P<0.05). Postoperative complications were observed in 37.2% of patients. Trocar site hematoma (P=0.02), wound complications (P=0.02), and intra-abdominal collection (P=0.01) occurred more frequently in patients with cirrhosis (Child B and C class) than in patients without cirrhosis. One case of continuing hemorrhage from the gallbladder bed required a reoperation for hemostasis. Two patients with Child-Pugh class C and 1 patient with class B cirrhosis developed ascites after surgery; 1 patient with Child-Pugh class A had bile leakage. No deaths occurred. CONCLUSIONS: LC is an effective and safe procedure and should be the treatment of choice for symptomatic cholelithiasis or cholecystitis in patients with compensated cirrhosis.