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2.
Philos Trans A Math Phys Eng Sci ; 377(2151): 20180418, 2019 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-31230571

RESUMO

In this article, we briefly summarize the experiments performed during the first run of the Advanced Wakefield Experiment, AWAKE, at CERN (European Organization for Nuclear Research). The final goal of AWAKE Run 1 (2013-2018) was to demonstrate that 10-20 MeV electrons can be accelerated to GeV energies in a plasma wakefield driven by a highly relativistic self-modulated proton bunch. We describe the experiment, outline the measurement concept and present first results. Last, we outline our plans for the future. This article is part of the Theo Murphy meeting issue 'Directions in particle beam-driven plasma wakefield acceleration'.

3.
Nature ; 561(7723): 363-367, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30188496

RESUMO

High-energy particle accelerators have been crucial in providing a deeper understanding of fundamental particles and the forces that govern their interactions. To increase the energy of the particles or to reduce the size of the accelerator, new acceleration schemes need to be developed. Plasma wakefield acceleration1-5, in which the electrons in a plasma are excited, leading to strong electric fields (so called 'wakefields'), is one such promising acceleration technique. Experiments have shown that an intense laser pulse6-9 or electron bunch10,11 traversing a plasma can drive electric fields of tens of gigavolts per metre and above-well beyond those achieved in conventional radio-frequency accelerators (about 0.1 gigavolt per metre). However, the low stored energy of laser pulses and electron bunches means that multiple acceleration stages are needed to reach very high particle energies5,12. The use of proton bunches is compelling because they have the potential to drive wakefields and to accelerate electrons to high energy in a single acceleration stage13. Long, thin proton bunches can be used because they undergo a process called self-modulation14-16, a particle-plasma interaction that splits the bunch longitudinally into a series of high-density microbunches, which then act resonantly to create large wakefields. The Advanced Wakefield (AWAKE) experiment at CERN17-19 uses high-intensity proton bunches-in which each proton has an energy of 400 gigaelectronvolts, resulting in a total bunch energy of 19 kilojoules-to drive a wakefield in a ten-metre-long plasma. Electron bunches are then injected into this wakefield. Here we present measurements of electrons accelerated up to two gigaelectronvolts at the AWAKE experiment, in a demonstration of proton-driven plasma wakefield acceleration. Measurements were conducted under various plasma conditions and the acceleration was found to be consistent and reliable. The potential for this scheme to produce very high-energy electron bunches in a single accelerating stage20 means that our results are an important step towards the development of future high-energy particle accelerators21,22.

4.
Appl Opt ; 56(29): 8201-8206, 2017 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-29047697

RESUMO

This paper investigates numerically dual-grating dielectric laser-driven accelerators driven by a pulse-front-tilted (PFT) laser, which extends the interaction length and boosts the electrons' energy gain. The optical system necessary to generate PFT laser beams with an ultrashort pulse duration of 100 fs is also studied in detail. Through two-dimensional particle-in-cell simulations, we show that such a PFT laser effectively increases the energy gain by (91±25) % compared to that of a normally incident laser with a waist radius of 50 µm for a 100-period dual-grating structure.

5.
J Microsc ; 241(1): 69-82, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21118206

RESUMO

There are many cases where it is desirable to reconstruct at high resolution a small volume from a larger sample. Here we describe the outcomes of a reconstruction trial based on real samples aimed at delineating the practical limits to which a small region of interest can be viewed from a large sample. Our approach has been to artificially truncate the sinograms of whole sample scans to simulate region of interest tomography. A simple filtered back projection algorithm has been applied, with the sinograms extended laterally in a simple manner to make up for the truncated portions. The impact of the degree of truncation (from 0% down to 99%), the number of projections used, as well as the position of the region of interest, on the faithfulness of the reconstruction is evaluated for a range of sample types. We have assessed the nature of, and extent to which, artefacts are introduced and the degree to which simple strategies can minimize them to an acceptable level without the need for complex reconstruction algorithms, projection stitching strategies or very large detectors. It is found that for a wide range of objects the effect of truncation on feature detection is negligible and that excellent images can be reconstructed if the number of projections is calculated not on the basis of the number of pixels on the camera, but on the number of pixels that would be required to scan the whole sample at the chosen pixel resolution. This paper demonstrates that in many cases more sophisticated reconstruction strategies are not necessary.


Assuntos
Tomografia com Microscopia Eletrônica/métodos , Processamento de Imagem Assistida por Computador/métodos , Animais , Chifres de Veado/ultraestrutura , Cervos , Camundongos , Crânio/ultraestrutura
6.
Appl Radiat Isot ; 67(6): 1033-41, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19249215

RESUMO

Even though the potential of phase contrast (PC) imaging has been demonstrated in a number of biological tissue samples, the availability of free-space propagation phase contrast images of real breast tumours is still limited. The aim of this study was to obtain phase contrast images of two different pathological breast specimens containing tumours of differing morphological type at two synchrotron radiation (SR) facilities, and to assess any qualitative improvements in the evaluation and characterisation of the masses through the use of phase contrast imaging. A second aim was to assess the effects of parameters such as detector resolution, beam energy and sample-to-detector distance on image quality using the same breast specimens, as to date these effects have been modelled and discussed only for geometric phantoms. At each synchrotron radiation facility a range of images was acquired with different detectors and by varying the above parameters. Images of the same samples were also acquired with the absorption-based approach to allow a direct comparison and estimation of the advantages specifically ascribable to the PC technique.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Interpretação de Imagem Radiográfica Assistida por Computador , Síncrotrons , Neoplasias da Mama/patologia , Feminino , Humanos
7.
Phys Rev A ; 54(4): 2737-2744, 1996 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9913785
8.
Acupunct Electrother Res ; 15(2): 85-94, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-1978506

RESUMO

In measuring the output of light from the human skin, we estimated the total photon rates to be of the order of 170-600 photons/s/cm2, depending on anatomical location. The light was strongest at the red end of the spectrum, but fell below detectable levels in the ultraviolet. Significant variations were observed between individuals in both photon rate and spectral profile. The photon rate also varied significantly with time for a single individual. The possible source of this light and its significance are discussed.


Assuntos
Medições Luminescentes , Fenômenos Fisiológicos da Pele , Desenho de Equipamento , Mãos , Humanos , Radiação , Pele/irrigação sanguínea , Temperatura Cutânea/fisiologia , Análise Espectral
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