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Exp Aging Res ; 25(3): 255-65, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10467515

RESUMO

Previous research has shown that forced expiratory volume (FEV) is a useful predictor of remaining life in older adults. The present analyses are an attempt to replicate results from a study of Swedish twins which demonstrated substantial heritability of FEV with a sample of middle-aged Russian adult twins. Data were collected from 116 pairs of Russian twins (monozygote = 71, dizygotic = 45, mean age = 40.9 years). Phenotypic correlations between FEV, age, gender, height, and cigarette consumption (in pack years) were all significant, ranging from -.72 to .31. After the effects of age, gender, height, and smoking were partialled out of FEV, quantitative genetic analyses were conducted. Shared environmental effects were significant, accounting for 47% of the variance in FEV. Genetic effects, which accounted for about 28% of the variance, could be dropped from the model without a significant decrease in the fit. These results are discussed in relation to previous research conducted in other countries.


Assuntos
Envelhecimento/genética , Envelhecimento/fisiologia , Volume Expiratório Forçado/genética , Volume Expiratório Forçado/fisiologia , Adulto , Comparação Transcultural , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Federação Russa , Suécia , Gêmeos Dizigóticos , Gêmeos Monozigóticos
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