RESUMO
Due to the numerous health benefits and therapeutic properties, herbs and plant metabolites/extracts are gaining popularity. This is particularly evident in the current era of drug resistance and the adverse effects of chemical drugs. Ocimum basilicum, also known as basil, has been extensively studied for its pharmacological benefits, including antimicrobial, antifungal, antioxidant, anti-inflammatory, antiviral, and wound healing properties. As a result, this plant has the potential to treat a wide range of diseases in both humans and animals. Ocimum basilicum contains various bioactive chemical compounds, such as neryl acetate, 1,8-cineole, p-allylanisole, geraniol, methyl eugenol, methyl chavicol, and trans-α-bergamotene. The latest advancements in technology can be utilised to enhance the beneficial properties of raw Ocimum basilicum extract. This review compiles and presents the profile of phytocomponents and pharmacological properties of Ocimum basilicum. The findings presented here will contribute to further research on this remarkable herb, aiming to develop effective pharmaceutical solutions for various health issues in humans and animals.
RESUMO
Heavy metal (HMe) pollution in regions with mining and metallurgy activities is known to be a serious environmental problem worldwide. Hydrological processes contribute to the dissemination of HMes (drainage, precipitation, flow rate). The aim of the present study is to investigate the microbial community structure in ten river sediments sampled in different regions of East Kazakhstan, which are contaminated with HMes. The overall degree of sediment contamination with HMes (Cr, Cu, Zn, Pb, and Cd) was assessed using the pollution index Zc, which ranged from 0.43 to 21.6, with the highest in Ridder City (Zc = 21.6) and Ust-Kamenogorsk City, 0.8 km below the dam of the hydroelectric power station (Zc = 19.6). The tested samples considerably differed in organic matter, total carbon, nitrogen, and phosphorus content, as well as in the abundance of HMe-related functional gene families and antibiotic resistance genes. Metagenomic analysis of benthic microorganisms showed the prevalence of Proteobacteria (88.84-97.61%) and Actinobacteria (1.21-5.98%) at the phylum level in all samples. At the class level, Actinobacteria (21.68-57.48%), Betaproteobacteria (19.38-41.17%), and Alphaproteobacteria (10.0-39.78%) were the most common among the classified reads. To the best of our knowledge, this is the first study on the metagenomic characteristics of benthic microbial communities exposed to chronic HMe pressure in different regions of East Kazakhstan.
