[The new chemical preparation arbidol: its prophylactic efficacy during influenza epidemics]. / Novyi khimiopreparat arbidol: profilakticheskaia éffektivnost' vo vremia épidemii grippa.

In four controlled observations on the organized groups of students and industrial workers during the epidemics of influenza A in 1988-1989 Arbidol, a new chemopreparation, was found to be well tolerated and to produce a pronounced prophylactic effect when administered in a dose of 0.2 g (2 tablets of 0.1 g) daily for 10-18 days. After the 18-day prophylactic course of Arbidol the induction of serum interferon was found.

[Assessment of the effectiveness of inactivated influenza vaccines for adults]. / Otsenka éffektivnosti inaktivirovannykh grippoznykh vaktsin dlia vzroslykh.

In 9 controlled epidemiological observations (1977-1984) the effectiveness of modern Soviet whole-virion vaccines was studied in organized groups of adults and at industrial enterprises. During the epidemic outbreaks of influenza of different etiology and intensity morbidity rate in influenza and acute respiratory diseases was shown to decrease 1.1-2.2 times among the vaccinees, depending on the correspondence of epidemic and vaccine influenza strains. The absence of influenza virus B in inactivated influenza vaccines was the reason for their low effectiveness during influenza outbreaks of mixed etiology B + A (H1N1).

[Results of a study of the effectiveness of simultaneous immunization against influenza with live and inactivated vaccines (1980-1983)]. / Itogi izucheniia éffektivnosti odnovremennoi immunizatsii protiv grippa zhivoi i inaktivirovannoi vaktsinami (1980-1983 gg.).

A comparative evaluation of immunological and epidemiological effectiveness of commercial live and killed vaccine preparations used simultaneously or separately was first carried out in simultaneous field trials of various methods of influenza vaccine prevention in a human population of 10,449 subjects. The advantage of simultaneous immunization was confirmed by immunological parameters and protective effect in the period of influenza A epidemic of 1983. The correlation of immunological and epidemiological effectiveness of influenza vaccines in joint or separate administration is discussed.

[Characteristics of the immunological and protective effect in the simultaneous and separate use of live and killed influenza vaccines]. / Osobennosti immunologicheskogo i zashchitnogo éffekta pri odnovremennom i razdel'nom primenenii zhivykh i ubitykh grippoznykh vaktsin.

Simultaneous immunization with inactivated and live influenza vaccines is characterized by a more rapid and intensive formation of local protection and humoral immunity persisting for 5 months at a higher level than after separate administration of inactivated and live vaccines. The live vaccine was found to be the major factor enhancing the immune response and local protection in combined immunization. Administration as components of a live bivaccine of influenza serotype A viruses with a different degree of attenuation was not accompanied by higher reactogenicity but led to a sharp decrease of immunogenic activity that indicated incompatibility of such viruses in a bivaccine.

[Immunological effectiveness of a method for simultaneous immunization against influenza using live and inactivated vaccines]. / Immunologicheskaia éffektivnost' sposoba odnovremennoi immunizatsii protiv grippa zhivoi i inaktivirovannoi vaktsinami.

A significant increase in immunological effectiveness of simultaneous immunization with a killed and live influenza vaccine as compared with separate use of these preparations has been demonstrated. The simultaneous immunization better protected the upper respiratory tracts of the vaccinated volunteers, inhibiting reproduction of the challenge influenza virus with residual virulence. A live vaccine from the "old" influenza A/6/50 (H1N1) was found to produce a protective effect on the current influenza A/1977 (H1N1) virus with residual virulence.