[Acute pancreatitis triggered by an impacted minor papillary stone in a patient with pancreas divisum improved after spontaneous evacuation of the pancreatic stone:a case report].

A 56-year-old woman with epigastric pain was admitted to our hospital. Blood tests and abdominal computed tomography (CT) suggested acute pancreatitis. Abdominal CT revealed a pancreas divisum and stone in the minor papilla. Stone impaction was the most likely cause of the acute pancreatitis. The patient's abdominal pain promptly improved after admission. The patient was treated conservatively, and the pancreatitis resolved. Abdominal CT on the 10th day confirmed spontaneous evacuation of the pancreatic stone. This is a rare case of acute pancreatitis in a patient with pancreas divisum triggered by an impacted stone in the minor papilla, which improved after spontaneous evacuation of the pancreatic stone.

Absolute phase retrieval of shiny objects using fringe projection and deep learning with computer-graphics-based images.

Fringe projection profilometry is a high-precision method used to measure the 3D shape of an object by projecting sinusoidal fringes onto an object. However, fringes projected onto a metallic or shiny object are distorted nonlinearly, which causes significant measurement errors. A high-precision measurement method for shiny objects that employs computer graphics (CG) and deep learning is proposed. We trained a deep neural network by projecting fringes on a shiny object in CG space. Our results show that the method can reduce the nonlinear fringe distortion caused by gloss in real space.

1.8 µm band broadband hybrid light source employing a combination of a super luminescent diode and thulium-doped fiber amplifier.

We have proposed a broadband hybrid light source that combines a super luminescent diode (SLD) and thulium-doped fiber amplifier (TDFA) and operates in the 1.8 µm band. This light source can improve the characteristics of the output spectrum by amplifying the output light of the SLD with TDFA. In this study, we investigate the dependence of the output spectral characteristics of the hybrid broadband light source on the thulium-doped fiber (TDF) length used in the TDFA as well as the output spectra of three newly developed SLDs of 1660, 1690, and 1730 nm bands. In the evaluation of the output bandwidth, there are various definitions of output bandwidth, but we adopted the bandwidth with power density of over -40dBm/0.1nm. This is because it is possible to evaluate in this band with a dynamic range of "30 dB/0.1 nm" by using a general optical spectrum analyzer. The hybrid light source achieves the bandwidth of 332 nm, from 1579 to 1911 nm, and a high total output power of over 15 dBm. The maximum ripple was less than ∼0.1dB, which is similar to the maximum value of that of the SLD, without any deterioration in the ripple characteristics owing to the hybrid configuration of the SLD and TDFA.

[Voluntary inoculation of hepatitis B vaccine at pediatric medical institutions].

We conducted a questionnaire survey on voluntary inoculation of hepatitis B (HB) vaccine to children at 79 pediatric clinics. The voluntary vaccination rate was 65.2%, the desired vaccination target was "all infants" at 84.8% of clinics, the recommended method was "only when the patient wishes" at a rate of 80.0%, and "actively recommended" at 20.0%. If there was a request, 71.7% of clinics answered that they would like to recommend it in the future, and 38.9% said that it was difficult to recommend it because of the voluntary nature of vaccination. The requests were "expansion of the scope of regular vaccination" at 60.9% of clinics and "enlightenment activities and information provision" at 54.3%. Since it was suggested that voluntary vaccination is difficult to recommend, it is necessary to proactively provide information and public relations activities regarding its necessity to medical personnel and parents.

[Questionnaire survey on hepatitis B vaccine in clinics].

We conducted a questionnaire survey on the status of implementation of hepatitis B vaccination and HBs antibody testing. It involved medical personnel covering 484 regional medical institutions in the Osaka Province. Results showed that the recognition rate was 30.1%, the hepatitis B vaccination implementation rate was 38.9%, and that of HBs antibody testing was 38.9%. Although 42.5% of the medical institutions had experienced needle-stick injuries, some medical institutions did not respond properly. The low implementation rate of hepatitis B vaccination and HBs antibody test could be explained by lack of recognition for hepatitis B infection control guidelines. Therefore, we can achieve a possible improvement in the control of infection in the Province, if sensitization programs on hepatitis B infection control are organized in the various regional medical institutions in order to provide adequate information and raise awareness on the importance of respecting these guidelines.

[The effect of introducing an on-call system for attending physicians].

Gastroenterologists working in hospitals that have adopted the chief physician system are often required to work overtime during the night and on holidays treating critically ill patients and ordering emergency tests. To help alleviate the attending physician's duties, our hospital initiated an on-call system in October 2019 to replace the existing system. Changes in overtime hours worked and business stress before and after the introduction of the on-call system were verified. After the introduction of the on-call system, both overtime hours and the number of holidays worked decreased and work stress was reduced. We report that the on-call system is a suitable alternative to the attending physician system because it increases the work efficiency and satisfaction of attending physicians.

Familial Mediterranean Fever without Fever.

Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease commonly observed around the Mediterranean basin presenting as recurrent febrile episodes. We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy 34-year-old man presented with frequent episodes of abdominal pain, which resolved spontaneously. During the attacks, the patient was afebrile, but the inflammatory marker levels in his blood were increased. Abdominal CT demonstrated enhancement of the jejunal membrane. After the initiation of colchicine therapy, the patient experienced no attacks for more than one year. The diagnosis of FMF was confirmed by a genetic analysis.

[Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report].

Peripheral neuropathy reportedly develops after a long period of metronidazole administration. Here, we report a case of amoebic colitis in which peripheral neuropathy occurred approximately 24 hours after administering metronidazole. A 76-year-old man presented with mucous and bloody stool. Initially, lower gastrointestinal endoscopy and stool analysis confirmed the occurrence of amoebic colitis, and metronidazole was then intravenously administered. The following day, however, the patient experienced a diminished sensation in a glove-and-stocking distribution in his extremities, followed by bilateral burning foot pain. After the withdrawal of metronidazole, the symptoms improved and finally disappeared 3 months later.

Three-dimensional microscopic imaging through scattering media based on in-line phase-shift digital holography.

Microscopic three-dimensional imaging and phase quantification for objects hidden behind a scattering medium by using in-line phase-shift digital holography are proposed. A spatial resolution of 1.81 µm and highly accurate quantitative phase imaging are demonstrated for objects behind a scatter plate. Three-dimensional imaging was confirmed using objects with a depth difference of 1.32 mm. Further, imaging was performed using rat skin as a demonstration for imaging through a complex multilayer scattering medium, where a spatial resolution close to the theoretically predicted value was achieved by experiment.

Low-cost optical fiber temperature-sensing system employing optical transceivers for Ethernet and long-period fiber grating.

Optical fiber sensors have numerous advantages over electrical sensors. However, in some cases, sensing systems based on optical fiber sensors are inferior to electrical sensors in terms of cost because expensive instruments are required. Therefore, cost-effective options must be developed. Here, inexpensive optical transceivers (OTRs) for Ethernet were used instead of a broadband light source and optical spectrum analyzer, and a CO2 laser-induced long-period fiber grating (LPFG) was used as a temperature sensor. The sensing system was implemented introducing OTRs and LPFG in an experimental internet protocol (IP) over Ethernet. The results showed that a low-cost sensing system can estimate the ambient temperature of the LPFG based on the no-reply rate for the internet control message protocol echo request. Regarding the sensing performance, the measurable range was ∼100°C with ±4.5°C errors.

Optical correlation-based cross-domain image retrieval system.

A novel cross-domain image retrieval system that is based on a high-speed optical correlator with a coaxial holographic system is presented. Our newly designed conversion module for the optical correlator allows various kinds of data to be converted to pagedata with a uniform optical intensity by using an autoencoder, which is difficult with other conventional methods. By using our conversion module, an existing model for deep learning could be utilized as a feature extractor. A sketch-based cross-domain image retrieval system with the goal of discovering similar photos by querying freehand human sketches was experimentally demonstrated using our optical correlator. We believe that this proposed optical correlation-based system helps expand the applications of the optical correlator.

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

Cynomolgus monkeys are used frequently in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug, efavirenz, is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly metabolized by cynomolgus monkey P450 2C9. In this study, plasma concentrations of efavirenz were assessed in six cynomolgus monkeys genotyped for P450 2C9 c.334 A > C (I112L) (three wild-type, one heterozygote and two homozygotes) by high performance liquid chromatography with tandem mass spectrometry. After intravenous administration at a dose of 1.0 mg/kg, biphasic plasma elimination curves of efavirenz were seen in these cynomolgus monkeys. The mean plasma concentration of the primary metabolite 8-hydroxyefavirenz (1 h after treatment, with hydrolysis by ß-glucuronidase) in the wild-type group was significantly higher (4.0-fold) than the combined heterozygous and homozygous group mean. The area under the plasma concentration-time curve value of efavirenz in the homozygous group after oral administration at a dose of 2.0 mg/kg was significantly higher (2.0-fold) than the combined wild-type and heterozygous group. These results collectively indicated that P450 2C9 c.334 A > C (I112L) variation was associated with efavirenz metabolic clearance in vivo. Cynomolgus P450 2C9 polymorphism might account for interindividual variations of efavirenz metabolism in cynomolgus monkeys. Copyright © 2016 John Wiley & Sons, Ltd.

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

1. Pharmacokinetics of human cytochrome P450 probes (caffeine, racemic warfarin, omeprazole, metoprolol and midazolam) were investigated after single intravenous and oral administrations at doses of 0.20 and 1.0 mg kg(-1), respectively, in combination to three young (3-year-old) and three aged (16-year-old) cynomolgus monkeys. 2. The plasma concentrations of caffeine and R-/S-warfarin decreased slowly in a monophasic manner, but those of omeprazole, metoprolol and midazolam decreased rapidly, in a similar manner to those as reported for pharmacokinetics in humans. 3. The mean maximum concentrations of R- and S-warfarin (4.6 and 3.7 µg/mL, respectively) in aged monkeys after oral administration were significantly higher than those in young monkeys (3.3 and 2.7 µg/mL). The mean clearance (CL) values of midazolam in aged monkeys (9.5 mL/min/kg) were significantly lower than those in young monkeys (13 mL/min/kg). 4. Individual intrinsic CL values for omeprazole (r = 0.29) and metoprolol (r = 0.30) of individual monkey livers were inversely correlated with their ages significantly (p < 0.05) in liver microsomes prepared from 55 cynomolgus monkeys. 5. These results suggest that cynomolgus monkeys could be a good model for humans, especially with particular characteristics in reduced CLs of some human P450 substrates by aging.