RESUMO
Surgical resection is recommended for advanced-stage, resectable glottic cancer. However, total laryngectomy results in the loss of vocal function and reduces patients' quality of life. At our institution, patients with cT3N0M0 stage III resectable glottic cancer who wish to preserve their larynx are treated with super-selective cisplatin infusion with concomitant radiotherapy (RADPLAT) to improve local control over systemic chemotherapy. Herein, we present 4 patients with glottic cancer who underwent biweekly intra-arterial infusion chemotherapy combined with radiation therapy 3 times. For intra-arterial infusion chemotherapy, 100 mg cis-diaminodichloroplatinum was infused into the superior thyroid artery, including the superior laryngeal artery branch. Thereafter, intensity-modulated radiation therapy was administered at doses of 70 Gy in 35 fractions for 3 patients and 66 Gy in 33 fractions for 1 patient. These patients showed complete response after chemoradiotherapy with no recurrence or metastases during the follow-up period to date (mean follow-up period: 56 months, range: 39-76 months).
RESUMO
The purpose was to investigate air-kerma area product (PKA) and entrance surface air-kerma rate ([Formula: see text]a,e) on the effect of the shape of automatic dose rate control (ADRC) in the presence of a wedge compensation filter. We compared and evaluated the variability of the X-ray output using a combination of wedge compensation filters and the ADRC. Two ADRC shapes (round and square) and three poly-methyl-methacrylate thicknesses (15, 20, and 25 cm) were used. A wedge compensation filter was inserted 2 cm at a time, up to 6 cm. When the wedge compensation filter was inserted to 6 cm for 20 cm of poly-methyl-methacrylate, the X-ray output fluctuated significantly. The PKA was reduced by 39% when the wedge compensation filter was inserted to 6 cm and by 59% when it was inserted to 4 cm under round-type for 20 cm poly-methyl-methacrylate. The shape of the ADRC affects [Formula: see text]a,e and PKA.
