[Psychophysiological approaches to assessing patients with painful and painless forms of ischemic heart disease]. / Psikhofiziologicheskie podkhody k otsenke bol'nykh s bolevoi i bezbolevoi formoi IBS.

By the results of bicycle ergometry test 28 coronary heart disease (CHD) patients were divided into 2 groups: with a pronounced anginal syndrome (group 1) and coronary insufficiency evident on ECG (group 2). Vegetative and psychophysiological parameters obtained in the examinees (heart rate, arterial pressure, pain threshold, personality profile) demonstrated that increased pain sensitivity, anxiety, predisposition to neurotic reactions were more typical for patients of group 1. Therapeutic response was achieved after psychophysiological correction by means of creation and activation of artificial stable functional connections of the brain.

[Association of the lipid composition of the blood and other risk factors of ischemic heart disease with tolerance to physical load according to data of repeated random examination of a male population]. / O sopriazhennosti lipidnogo sostava krovi i drugikh faktorov riska ishemicheskoi bolezni serdtsa s tolerantnost'iu k fizicheskoi nagruzke po materialam povtornogo byvorochnogo obsledovaniia muzhskoi populiatsii.

The paper is concerned with the results obtained during repeated examinations (an interval amounts to 7.6 years) of 479 men who were divided into 4 population groups. Of these, groups I and III including persons under and over 55 years were selected according to the tables of random numbers whereas the remaining two groups of the same age were selected during the primary screening with respect to hyperlipidemia signs. Groups I and III showed a significant rise of the share of persons with two or three risk factors (from 25.3 to 39.5 percent and from 40.8 to 51.6 percent, respectively). Groups II and IV, especially group II, demonstrated an opposite time-course of changes. The share of such persons decreased from 67.8 to 56.5 percent, which is most likely to be related with improvement of the nutrition regimen. Group I had an increase in the rate of ischemic responses (from 5.3 to 15.7 percent), while in the remaining groups it was unchanged. Groups II and IV were characterized by two tendencies: a rise of the share of persons with contraindications to the physical load and stabilization of the percentage of adequate responses to the treadmill test.

[Radiation-modifying effect of quinoline derivatives]. / Radiomodifitsiruiushchii éffekt proizvodnykh khinolina.

In experiments with hybrid mice (CBA X C57Bl)F1 and tetrahybrids (CBWA) a study was made of the radio-modifying properties of twelve quinoline derivatives. Among them three preparations, including quipazine [1(2-quinolyl)piperazine], possessed a 50% radioprotective effect. The radioprotective effect of piperazinylcinchonine acid hydrazides was the same as that of mexamine.

[Characteristics of the course of non-fatal ischemic heart disease (data of a prospective study of the open population of men over 40]. / Ob osobennostiiakh techeniia nesmertel'noi ishemicheskoi bolezni serdtsa po dannym prospektivnogo nabliudeniia za otkrytoi populiatsiei muzhchin starshe 40 let.

A total of 2096 males born in 1916-1935, residing by 1976 in the Petrogradsky District of Leningrad, were twice examined (with an interval of 7.6 yrs) using epidemiological methods. This group was equal to 53.6% of the persons subjected to the first screening. Data on the dead and those who had not come to the second screening, were not analyzed. The total frequency of nonfatal CHD from 1976 up to 1984 raised from 12.6 to 19.2%. As was shown by the assessment of a WHO questionnaire with relation to angina of effort and an analysis of ECG at rest, CHD was undetectable during the second screening in some of the examinees with CHD detected during the first screening. Further on the angina syndrome was not reaffirmed in 52.3% of the patients with previously diagnosed angina, "ischemic" ECG changes were not recorded in 37.1% of the persons with previously detected ischemic codes. Positive ECG time course was noted in 52.1% of the persons with ECG changes typical of CHD detected during the first screening. In spite of a marked tendency to an increase in the total CHD frequency a long-term observation demonstrated a possibility of a favorable time course of chronic CHD and remission in this disease.

[Dynamics of the leading risk factors of ischemic heart disease in a male population over 40-years-old according to the results of a prospective epidemiologic study]. / O dinamike vedushchikh faktorov riska ishemicheskoi bolezni serdtsa v populiatsii muzhchin starshe 40 let po dannym prospektivnogo épidemiologicheskogo nabliudeniia.

The purpose of the survey was to study the time course of the leading CHD risk factors in an open population of men born in 1916-1935 during a prolonged prospective study and to specify CHD interrelationship with new cases of disease and a course of nonfatal CHD. A population of 5000 males from one of the Leningrad districts was examined with an interval of 7.6 yrs. The first screening included 3907 persons, the repeated screening 2096. In the period of observation the number of persons with the absence of leading risk factors decreased (from 11.5 to 9.6%), the frequency of arterial hypertension (AH) increased (from 32.9 to 42.3%), the proportion of examinees with atherogenic dyslipoproteinemia (DLP) remained the same. By the results of the first screening in 50% of the persons with atherogenic DLP the blood lipid composition in 7.6 yrs returned to normal; AH persisted in 80% of the examinees. The presence of the 3 leading risk factors during the first and second screenings was accompanied by the highest frequency of stable CHD and the highest index of new cases of disease.

[Characteristics of the adequate and pathological reactions to the standard treadmill test in a female population 20 to 69 years old]. / Kharakteristika adekvatnykh i patologicheskikh reaktsii na standartnyi tredmilovyi test v populiatsii zhenshchin 20--69 let.

Treadmill exercise tests were carried out in 397 women, aged 20 to 69, who were selected at random from an unorganized population. Four types of response were identified: ischemia, reduced stress tolerance due to excessively elevated systolic arterial blood pressure or other causes; reduced stress tolerance due to premature muscular fatigue or dyspnea (in less than 9 minutes of exercise) and the adequate type. The parameters of adequate response to physical stress were established. The incidence of ischemic response was relatively small in women, as compared to men. Ischemic response was only seen in women between 50 and 69 years of age, making a 4.5% rate.

[Arterial tonus in men 40 to 59 with hypercholesterolemia, arterial hypertension and ischemic heart disease]. / O tonuse arterii u muzhchin v vozraste 40--59 let pri giperkholesterinemii, arterial'noi gipertenzii i ishemicheskoi bolezni serdtsa.

A study was made of the rate of pulse wave spreading (RPWS) in the elastic type vessels (the aorta, femoral artery) and in the muscular type vessels (the radial artery) at rest and in treadmill exercise in 363 men aged 40 to 59 residing in the Petrogradsky District of Leningrad and in 62 patients with previous transmural myocardial infarction (TMI). A distinct rise of RPWS in the elastic type vessels was established in persons with hypercholesterolemia without CHD and in CHD irrespective of a cholesterol level in the blood. In the patients after TMI, RPWS did not differ from that in healthy men indicating correlation between RPWS values and myocardial contractility.

[Type of response reaction to the exercise test and mortality over a 6-year follow-up period in a male population over 40]. / Tip otvetnoi reaktsii na probu s fizicheskoi na probu s fizicheskoi nagruzkoi i smertnost' za 6-letnyi period nabliudeniia v populiatsionnoi gruppe muzhchin starshe 40 let.

Cardiologic investigation and the treadmill test were conducted in two population samples of men aged 40-59: a randomly selected group of 498 men and a "hyperlipidemic" group of 391. Four categories of subjects were identified: 1) subjects to whom physical stress is contraindicated; 2) subjects with ischemic response; 3) subjects with reduced stress tolerance in the absence of typical ischemia; and 4) those with an adequate response to treadmill exercise. Population mortality figures analysed by the groups over a 6-year follow-up period demonstrated the highest mortality in groups 1 and 2 (188.9 and 127 per 1000) and the lowest rate in group 4 (27.8 per 1000).

[Physical loading tolerance in male population groups 20 to 69 years of age without the angina syndrome and normal and altered resting ECGs]. / Tolerantnost' k fizicheskoinagruzke v populiatsionnykh gruppakh 20--69 let bez anginoznogo sindroma s normal'noi i izmenennoi EKG pokoia.

The authors analyse the results of the treadmill test, obtained in a male population (868 persons) representing three groups aged 20 to 39, 40 to 59 and 60 to 69 years. Persons with angina pectoris of effort were excluded from the population of the three groups. The rate of the ischemic reactions was minimal in the youngest group (0.8%), drastically rising in the second group (up to 7.1%). The highest rate of the reactions was observed in the third group. The presence of changes common to coronary heart disease on the initial ECG deteriorated exercise tolerance and increased the rate of the ischemic reactions (up to 25.5% in the second group). Submaximal exercise is one of the most available and efficacious methods for recognizing latent CHD under the conditions of the epidemiological surveys of men over 40 years of age.

[Mortality rate among men aged 40-59 based on the data of intravital screening]. / Smertnost' populiatsii muzhchin 40-59 let po dannym prizhiznennogo tselevogo skrininga.

The article compares the results of the screening of 3820 males aged 40 to 59 years, representative of the open population, and the mortality rate over a 6-year-follow-up. Mortality was the highest in males in whom angina pectoris was combined with "ischemic" codes on the ECG and the lowest in subjects without CHD symptoms and without codes of left ventricular hypertrophy. The study showed a fairly high prognostic value of the epidemiologic method of CHD diagnosis.

[Partial and combined effect of arterial hypertension and atherogenic shifts in blood lipid fractions on the incidence of ischemic heart disease]. / Partsial'noe i sochetannoe vliianie arterial'noi gipertenzii i aterogennogo sdviga lipidnykh fraktsii krovi na chastotu ishemicheskoi bolezni serdtsa (populiatsionnoe issledovanie).

The results of a purposeful epidemiologic study involving 3896 men and 1502 women aged 40-69 years from the same city district are presented. To correlate the prevalence of coronary heart disease (CHD) and the level of arterial pressure (AP), subjects with a low coefficient of atherogenicity (a ratio of pre-beta-and beta-lipoproteins to alpha-lipoproteins) from the first quartil (1360) and the fourth quartil (1325) were selected. The statistical distribution series was plotted for each decade of age in males and females differentially. The atherogenic composition of blood lipids was found to be the risk factor determining CHD incidence in males aged 40-59 and 50-59 and in females aged 50-59, whereas in subjects over 60 years of both sexes it was elevated AP levels. The presence of two leading CHD risk factors was associated with a considerable increase in CHD prevalence in all age groups of both sexes.

[Clinico-epidemiological characteristics of ischemic heart disease in men of different age groups from the data of a single screening of a random population]. / Kliniko-épidemiologicheskie osobennosti ishemicheskoi bolezni serdtsa u muzhchin raznykh vozrastnykh grupp po dannym odnomomentnogo obsledovaniia neorganizovannoi populiatsii.

A total of 742 men, aged 20-69 and representative of a random male population from a Leningrad district, were investigated. The incidence of coronary disease was 3.2% in subjects aged 20-29, and 33.3% in those aged 60-69. In 40-49-year-olds, coronary disease was mostly manifested in angina of effort (57.9%), whereas painless forms reflected in ECG at rest prevailed (55-58.5% in men above 50 years of age. The frequency of ischemic response to the treadmill test increases with advancing age (8.3% in subjects aged 40-49 and 28.2% at age 60-69). The results of the WHO Questionnaire on Angina of Effort demonstrate that ECG at rest and exercise tests are mutually complementary procedures for epidemiologic diagnosis of coronary disease, their combination ensuring the fullest possible identification of coronary disease in population screenings.