1.
Bioorg Med Chem Lett
; 11(13): 1671-3, 2001 Jul 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11425534
RESUMO
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
Assuntos
Aminofenóis/química , Antineoplásicos/farmacologia , Mitose/efeitos dos fármacos , Sulfonamidas/química , Ácidos Sulfônicos/farmacologia , Antineoplásicos/química , Humanos , Ácidos Sulfônicos/química , Células Tumorais Cultivadas
2.
Bioorg Med Chem Lett
; 11(7): 871-4, 2001 Apr 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11294380
RESUMO
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.