Results of a real-world study on vortioxetine in patients with major depressive disorder in South East Asia (REVIDA).

OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from August 2016 to April 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months. Depression severity was assessed using the PHQ-9 questionnaire (patient assessed) and CGI-S scale (physician assessed); cognitive function was assessed with the PDQ-D questionnaire; work productivity and activity impairment (WPAI) was assessed with the WPAI questionnaire. RESULTS: At baseline, 89.9% of patients were moderately to severely depressed (PHQ-9 score ≥10). During the 3 month treatment period, mean ± SD PHQ-9 score decreased from 18.7 ± 5.7 to 5.0 ± 5.3, mean ± SD CGI-S score decreased from 4.4 ± 0.7 to 2.2 ± 1.1 and mean ± SD PDQ-D score decreased from 42.1 ± 18.8 to 13.4 ± 13.0. By Month 3, response and remission rates reached 80.8% and 59.0%, respectively. Work productivity loss decreased from 73.6% to 30.5%, while activity impairment decreased from 71.5% to 24.6%. Positive correlations were observed between PHQ-9, PDQ-D, and WPAI work productivity loss and activity impairment. By Month 3, 82.0% of patients were either not depressed or only mildly depressed (PHQ-9 score ≤9). CONCLUSION: In real-world clinical settings, vortioxetine was effective in reducing depression severity and improving cognitive function and work productivity in SEA patients with major depression.

Knowledge, attitudes and practices vis-a-vis cervical cancer among registered nurses at the Faculty of Medicine, Khon Kaen University, Thailand.

BACKGROUND: Cervical cancer is the most common cause of death from cancer among women in Thailand and in almost all patients, human papillomavirus (HPV) has been found. Various international studies indicate that the knowledge level vis-à-vis cervical cancer and HPV in the general population as well as healthcare professionals is low, but no such study has yet been done in Thailand. OBJECTIVES: Our study's aim was to ascertain the level of knowledge, the attitudes and practices regarding cervical cancer among registered nurses working in Srinagarind (university) Hospital in an urban setting in Northeast Thailand. MATERIALS AND METHODS: Systematic sampling was used and self-administered questionnaires were sent to 149 registered nurses; 133 (89.3%) of whom responded. Data were processed using descriptive statistics including frequency, percentages and the 95% CIs. RESULTS: The respondents' averaged 34.6 years of age (median, 33; range, 21-56) while 54.6% had sexual partners and 61.4% had had normal deliveries. The respective median knowledge score, interquartile range and mean knowledge score and range for cervical cancer vs. HPV vs. cervical cancer prevention were: 11.00, 5.0, 10.14 (95%CI 9.6, 10.7), 0-15 vs. 4.00, 2.0, 3.58 (95%CI 3.5-4.2), 0-7 vs. 8, 3.00, 7.5 (95%CI 7.1-7.9), 1-11. 66.2% would like to have prophylactic HPV vaccines because they thought that it would prevent HPV infection (77.3%) or prevent cervical cancer (39.1%), which are major misunderstandings. CONCLUSION: Almost all of the registered nurses working at Srinagarind Hospital have a moderate level of knowledge regarding cervical cancer and HPV but there are still some major misunderstandings; thus, educational pamphlets, notices and hospital announcements would be useful in increasing their knowledge.