[Rhabdomyolysis due to drug-drug interaction of atorvastatin and cobicistat]. / Rhabdomyolyse durch Arzneimittelinteraktion von Atorvastatin und Cobicistat.

A 53-year-old man presented with rhabdomyolysis and acute kidney injury. The symptoms were presumably caused by a drug-drug interaction between an antiretroviral drug combination and atorvastatin. As a booster, cobicistat can also increase the toxicity of statins via inhibition of the enzyme cytochrome p450 3A4 (CYP3A4). After stopping atorvastatin and after intravenous fluid therapy, the symptoms regressed completely.