RESUMO
Gliosarcomas account for 2% of glioblastomas. We report a case of gliosarcoma in a 65-year-old man, which presented as meningioma, and discuss diagnostic, therapeutic and prognostic aspects of this particular entity.
Assuntos
Neoplasias Encefálicas/cirurgia , Gliossarcoma/cirurgia , Idoso , Neoplasias Encefálicas/diagnóstico por imagem , Gliossarcoma/diagnóstico , Humanos , Masculino , Meningioma/diagnóstico , Meningioma/diagnóstico por imagem , Prognóstico , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
We report a case of a benign temporal meningioma in 1 month old infant. The diagnosis was revealed by atypical seizure. The physical exam was normal. We underline the epidemiological, clinical and prognostic aspects of this condition.
Assuntos
Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Convulsões/etiologia , Humanos , Lactente , Masculino , Neoplasias Meníngeas/complicações , Neoplasias Meníngeas/terapia , Meningioma/complicações , Meningioma/terapia , PrognósticoRESUMO
Pargyline undergoes metabolic N-oxidation in rat and rabbit liver microsomal preparations. The reaction requires oxygen and is NADPH dependent. N-oxidation and N-demethylation are equal in both control and induced rat liver microsomes, while N-oxidation is more dominant in rabbit tissue. Experiments investigating the CO-sensitivity and the effects of metyrapone suggest that cytochrome P-450 systems are involved in both reactions in the rat while an additional enzyme is responsible for the N-oxidation in the rabbit. Pargyline N-oxide is characterized by chemical instability and undergoes two consecutive rearrangements to yield propenal and Schiff bases, the latter undergoing hydrolysis to aldehydes and primary amines. Accordingly, due to the inherent instability of the N-oxide, metabolic N-oxidation of pargyline is, in addition to alpha-carbon oxidation, indicated as a metabolic route to benzaldehyde. Similarly the ease with which pargyline N-oxide generates propenal implicates N-oxidation as a metabolic route to be considered when evaluating the toxicity of pargyline.