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Saudi Med J ; 35(11): 1331-8, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25399209

RESUMO

OBJECTIVES: To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases. METHODS: This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted. RESULTS: The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity. CONCLUSION: The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations. 


Assuntos
Imunoglobulina A/imunologia , Cadeias kappa de Imunoglobulina/imunologia , Cadeias lambda de Imunoglobulina/imunologia , Nefropatias/epidemiologia , Rim/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Autopsia , Feminino , Patologia Legal , Humanos , Imunoglobulina A/metabolismo , Cadeias kappa de Imunoglobulina/metabolismo , Cadeias lambda de Imunoglobulina/metabolismo , Imuno-Histoquímica , Rim/imunologia , Rim/metabolismo , Nefropatias/imunologia , Nefropatias/patologia , Glomérulos Renais/imunologia , Glomérulos Renais/metabolismo , Glomérulos Renais/patologia , Masculino , Microscopia de Fluorescência , Pessoa de Meia-Idade , Estudos Prospectivos , Turquia , Adulto Jovem
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