RESUMO
Twenty cases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC
Assuntos
Carcinoma Basocelular , Linfócitos B , Linfócitos T , Imuno-Histoquímica , Anticorpos Monoclonais , Neoplasias de Cabeça e PescoçoRESUMO
Condensation of 5-acetyl-6-methoxy- (I) and 6-acetyl-5-methoxy-2,3-diphenylbenzofuran (II) with aromatic aldehydes gave the chalcones IIIa--f and IVa--f, respectively. Reaction of the chalcones IIIa--f and IVa--f with hydrazine hydrate-acetic acid mixture yielded the corresponding N-acetyl pyrazolines Va--f and VIa--f. The chalcones IIIa--f and IVa--f reacted with phenylhydrazine in ethanol to yield the corresponding phenylhydrazones VIIa--f and VIIIa--f. The latter hydrazones cyclize easily with boiling glacial acetic acid to the corresponding pyrazoline derivatives (IXa--f and Xa--f). The antibacterial activity of the chalcones and pyrazolines was investigated.
Assuntos
Benzofuranos/síntese química , Chalcona/síntese química , Hidrazonas/síntese química , Propiofenonas/síntese química , Pirazóis/síntese química , Bactérias/efeitos dos fármacos , Benzofuranos/farmacologia , Chalcona/análogos & derivados , Chalcona/farmacologia , Hidrazonas/farmacologia , Pirazóis/farmacologiaRESUMO
Reduction of 5-methoxy-6-formyl(Ia)- and 5-formyl-6-methoxy-2,3-diphenylbenzofuran (IVa) yielded 6- and 5-methyl derivatives Ib and IVb, respectively. Oxidation, hydrolysis and demethylation of Ib and IVb gave 2,2-dihydroxy-4-methyl-)IIc)-and2,4-dihydroxy-5-methylbenzofuran )Vc). The carboxamides Ie and IVe were obtained from the oximes Ic and IVc via the cyano derivatives Id and IVd. By condensation of the aldehydes If, IVf and VII with primary amines the corresponding Schiff bases (IIIa--c, VI and VIIIa--f) were obtained. The antibacterial activity of the Schiff bases and previously prepared benzofuran derivatives were investigated.