The infant-doctor relationship: an examination of infants' distress reactions in the presence of a doctor.

Fear of doctors is a common source of distress among infants; however, the underlying sources of this distress are unknown. To investigate the doctor-infant relationship, the behaviors of 61 healthy infants (176-617 days old) were observed in a simulated examination room. Their behaviors and electrocardiograms were recorded. Two groups of infants were analyzed: those who cried and those who did not. When an experimenter dressed in the doctor's attire entered the room, all 9 infants who were crying (14.8% of all infants) stopped crying, all infants gazed at the experimenter, and their mean heart rate (HR) decreased. After the auscultation started, 29.5% of all infants cried, and the HRs of infants who cried were higher than those of infants who did not cry. During the auscultation, 80.0% of infants who cried averted from the experimenter, while 34.4% of infants who did not cry. Within 5 s of gazing at the stethoscope, the number of infants who cried increased from 3 to 12, and their mean HR also increased. Our findings suggest that the fear of doctors is not due to the appearance of doctors but rather to specific actions performed by doctors, such as auscultation. Infants may regard a doctor's appearance as a source of interest. Furthermore, a stethoscope is a possible trigger for infants' crying. These behavioral observations suggest the potential for patient-centered care for infants.

Brain structure variation and individual differences in theory of mind among older adults.

The theory of mind (ToM) is not substantially influenced by aging, suggesting the emergence of various compensatory mechanisms. To identify brain regions subserving ToM in older adults, we investigated the associations of individual differences in brain structure with performance on the Reading the Mind in the Eyes Test (RMET), a widely used measure of ToM, using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). In contrast to findings obtained from young adults, where multiple cortical regions are implicated in ToM, VBM analysis revealed a significant positive correlation between RMET score and gray matter (GM) volume only in the right middle temporal gyrus, a region implicated in social cognition. Alternatively, TBSS revealed significant positive correlations between RMET score and the fractional anisotropy (FA) values in widespread white matter (WM) tracts, including the bilateral uncinate fasciculus, a region previously linked to RMET performance in young adults. We speculate that individual differences in WM integrity are strong influences on ToM among older adults, whereas the impact of individual differences in GM volumes is relatively limited.

Mealtime conversations between parents and their 2-year-old children in five cultural contexts.

Children all over the world learn language, yet the contexts in which they do so vary substantially. This variation needs to be systematically quantified to build robust and generalizable theories of language acquisition. We compared communicative interactions between parents and their 2-year-old children (N = 99 families) during mealtime across five cultural settings (Brazil, Ecuador, Argentina, Germany, and Japan) and coded the amount of talk and gestures as well as their conversational embedding (interlocutors, function, and themes). We found a comparable pattern of communicative interactions across cultural settings, which were modified in ways that are consistent with local norms and values. These results suggest that children encounter similarly structured communicative environments across diverse cultural contexts and will inform theories of language learning. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Paternal involvement in infant care and developmental milestone outcomes at age 3 years: the Japan Environment and Children's Study (JECS).

BACKGROUND: In developed countries, the time fathers spend on childcare has increased steadily in recent decades. However, studies on the relationship between paternal care and child outcomes remain scarce. Thus, we examined the association between paternal involvement in childcare and children's developmental outcomes. METHODS: We used Japan's largest birth cohort data, the Japan Environment and Children's Study, to examine the relationship between paternal involvement in childcare at the child's age of 6 months and developmental milestone outcomes at the child's age of 3 years (n = 28,050). Developmental delays were assessed with Ages and Stages Questionnaire. Potential mediation by maternal parenting stress at the child's age of 1.5 years was also examined. We used log-binomial regression analyses to estimate risk ratios. RESULTS: Fathers' high involvement in childcare was associated with a lower risk of developmental delay in gross-motor, fine-motor, problem solving, and personal-social domains compared with low involvement, adjusting for potential confounders. For example, the risk ratio with 95% confidence intervals was 0.76 [0.67, 0.86] for the gross-motor domain. We also observed that the associations were partially mediated by maternal parenting stress. CONCLUSIONS: Fathers' active involvement in childcare during infancy may promote young children's development, partially by reducing maternal parenting stress. IMPACT: Using Japan's largest birth cohort data (Japan Environment and Children's Study), we showed that paternal involvement in infant care might benefit young children's development. Fathers' active involvement in infant care was associated with a lower risk of developmental delays in gross-motor, fine-motor, problem solving, and personal-social domains. Maternal parenting stress may mediate the association between paternal involvement in infant care and child development outcomes at 3 years.

Empathic embarrassment towards non-human agents in virtual environments.

Humans feel empathic embarrassment by witnessing others go through embarrassing situations. We examined whether we feel such empathic embarrassment even with robot avatars. Participants observed a human avatar and a robot avatar face a series of embarrassing and non-embarrassing scenarios. We collected data for their empathic embarrassment and the cognitive empathy on a 7-point Likert scale. Both empathic embarrassment and cognitive empathy were significantly higher in the embarrassed condition compared to the non-embarrassed condition with both avatars, and the cognitive empathy was significantly higher with the human avatar. There was a tendency of participants showing a higher level of skin conductance while watching the human avatar go through embarrassing situations compared to the robot avatar. A following experiment showed that the average plausibility of the embarrassed condition was significantly higher with the human avatar compared to the robot avatar. However, plausibility scores for emotion were not significantly different among the conditions. These results suggest that humans can feel empathic embarrassment as well as cognitive empathy for robot avatars while cognitive empathy for robot avatars is comparatively lower, and that part of the empathic difference between human and robot avatars might be due to the difference of their plausibility.

Impact of prior bevacizumab therapy on the incidence of ramucirumab-induced proteinuria in colorectal cancer: a multi-institutional cohort study.

BACKGROUND: The association between prior bevacizumab (BEV) therapy and ramucirumab (RAM)-induced proteinuria is not known. We aimed to investigate this association in patients with metastatic colorectal cancer (mCRC). METHODS: mCRC patients who received folinic acid, fluorouracil, and irinotecan (FOLFIRI) plus RAM were divided into with and without prior BEV treatment groups. The cumulative incidence of grade 2-3 proteinuria and rate of RAM discontinuation within 6 months (6M) after RAM initiation were compared between the two groups. RESULTS: We evaluated 245 patients. In the Fine-Gray subdistribution hazard model including prior BEV, age, sex, comorbidities, eGFR, proteinuria ≥ 2 + at baseline, and later line of RAM, prior BEV treatment contributed to proteinuria onset (P < 0.01). A shorter interval between final BEV and initial RAM increased the proteinuria risk; the adjusted odds ratios (95% confidence intervals) for the intervals of < 28 days, 28-55 days, and > 55 days (referring to prior BEV absence) were 2.60 (1.23-5.51), 1.51 (1.01-2.27), and 1.04 (0.76-1.44), respectively. The rate of RAM discontinuation for ≤ 6M due to anti-VEGF toxicities was significantly higher in the prior BEV treatment group compared with that in the no prior BEV treatment group (18% vs. 6%, P = 0.02). Second-line RAM discontinuation for ≤ 6M without progression resulted in shorter overall survival of 132 patients with prior BEV treatment (P < 0.01). CONCLUSION: Sequential FOLFIRI plus RAM after BEV failure, especially within 55 days, may exacerbate proteinuria. Its escalated anti-VEGF toxicity may negatively impact the overall survival.

Exploring role of sleep aids in sleep problems in preschool children.

It is well known that children use sleep aids, such as blankets or soft toys, at bedtime. However, there is a lack of understanding regarding the factors associated with their use and role in addressing sleep problems. This study investigated 96 Japanese children aged 40 to 47 months to examine these associations. We measured children's stress (through a questionnaire and salivary cortisol [cortisol awakening response]), anxiety symptoms, behavioral problems, and temperament, and created a model to predict the status of sleep aid use. Furthermore, we explored the association between sleep aid use and children's sleep problems as evaluated by their caregivers. We found that children who used sleep aids were more likely to experience anxiety symptoms. Moreover, most children used sleep aids even when they co-slept with their caregivers and/or siblings. Their use was not uniquely associated with sleep problems. These findings suggest that sleep aid serves as a defense against anxiety, including that caused by the absence of a caregiver, rather than as a substitute for a caregiver. Our study sheds light on their role and emphasizes the importance of viewing development within the complex interactive processes of humans and objects.

Visual attention across cultures: Similarities and differences in child development and maternal attention styles.

Previous cross-cultural research has described two different attention styles: a holistic style, characterized by context-sensitive processing, generally associated with interdependent cultural contexts, and an analytic style, a higher focus on salient objects, generally found in independent cultural contexts. Though a general assumption in the field is that attention styles are gradually socialized in culture-specific interactions in childhood, empirical evidence for the proximal mechanisms underlying this development is scarce. This study aimed to document the emergence of cross-cultural differences in attention styles in three cultural contexts differing in social orientations, namely in urban middle-class families from Münster, Germany (i.e., more independent context), and Kyoto, Japan, and Indigenous-heritage families from Cotacachi, Ecuador (i.e., more interdependent contexts). Furthermore, to test the assumption that caregivers' attention guidance is one of the forces driving differential development, we investigated how caregivers guide children's attention. In total, 270 children between 4 and 9 years of age and their mothers participated in three tasks: an eye-tracking task, a picture description task and a forced-choice recognition task. Results indicate a mixed pattern of findings: While some tasks revealed the expected cultural differences, namely a higher object focus in Münster compared to Kyoto and Cotacachi, others did not. Regarding caregivers' attention guidance, we found that mothers in Münster more strongly emphasized the focal object than mothers in Kyoto and Cotacachi. The results are discussed in terms of culture-specific developmental trajectories and the generalizability of attentional processes across tasks and cultural contexts. RESEARCH HIGHLIGHTS: We investigated visual attention styles in 4- to 9-year-old children and their mothers from urban Germany, urban Japan, and rural Ecuador in three different tasks. Special emphasis lied on mothers' verbal attention guidance toward their children as a proximal mechanism underlying the emergence of culture-specific attention styles. Mothers from urban Germany guided their children's attention in more analytic ways than mothers from urban Japan and rural Ecuador. The relevance of verbal attention guidance in the development of culture-specific attention styles has been demonstrated beyond the East-West dichotomy.

Memory Monitoring and Control in Japanese and German Preschoolers.

Prior studies explored the early development of memory monitoring and control. However, little work has examined cross-cultural similarities and differences in metacognitive development in early childhood. In the present research, we investigated a total of 100 Japanese and German preschool-aged children's memory monitoring and control in a visual perception task. After seeing picture items, some of which were repeated, children were presented with picture pairs, one of which had been presented earlier and the other was a novel item. They then were asked to identify the previously presented picture. Children were also asked to evaluate their confidence about their selection, and to sort the responses to be used for being awarded with a prize at the end of the test. Both groups similarly expressed more confidence in the accurately remembered items than in the inaccurately remembered items, and their sorting decision was based on their subjective confidence. Japanese children's sorting more closely corresponded to memory accuracy than German children's sorting, however. These findings were further confirmed by a hierarchical Bayesian estimation of metacognitive efficiency. The present findings therefore suggest that early memory monitoring and control have both culturally similar and diverse aspects. The findings are discussed in light of broader sociocultural influences on metacognition.

A cross-cultural investigation of people's intuitive beliefs about the origins of cognition.

Nature vs. nurture is an enduring theme of studies of the mind. Past studies on American children and adults have revealed a preference for thinking that even fundamental cognitive abilities documented in human infants and non-human species are late-emerging and reliant on learning and nurture. However, little is known about the generalizability of this "intuitive empiricist" belief and what factors may help explain it. Adult participants (N = 600) reported their beliefs about the emergence of several fundamental cognitive abilities demonstrated by preverbal infants. Studies 1A-1C showed that adults from both Japan and the US similarly estimated an older age of onset for cognitive abilities in human children as compared to the findings of cognitive science and consistently attributed acquisition of these abilities to learning rather than innateness in humans, and they made these learning attributions more so for humans than for non-human species. Study 2 showed that participants' beliefs about biological evolution versus creationism were related to their age onset estimates for fundamental cognitive abilities, and their beliefs about the malleability of intelligence were related to participants' explanations of the origin of fundamental cognitive abilities. These findings suggest generalizable preferences for nurture over nature across both Eastern and Western cultures (Japan and the United States), which may be related to people's beliefs about human origins and the power of learning.

Social reward anticipation in infants as revealed by event-related potentials.

Infants engage in gaze interaction from the early stage of life. Emerging studies suggest that infants may expect social reward of shared attention before looking to the same object with another person. However, it was unknown about the neural responses during the anticipation of social rewards before shared attention in infants. We tested infants' reward anticipations in the gaze cueing situation measured by event-related potentials in the social association learning task. Six- to ten-month-old infants (N = 20) repeatedly observed that a female predictively looked toward the animation position (valid condition) or another female looking away from the animation (invalid condition). It was posited that infants could learn associations between female faces and the event of shared attention. The results showed that the stimulus preceding negativity which reflects reward anticipation before the animation presentation was elicited in the second half of the learning phases in the valid condition. Additionally, after the presentation of the face, N290 was greater in the second half of the learning phase than in the first half in the valid condition. These results suggest that infants can anticipate social reward from gaze cues, and learning the gaze cueing validity may affect not only reward anticipation but face perception.

Physiological arousal explains infant gaze following in various social contexts.

Gaze following (GF) is fundamental to central aspects of human sociocognitive development, such as acquiring language and cultural learning. Studies have shown that infant GF is not a simple reflexive orientation to an adult's eye movement. By contrast, infants adaptively modulate GF behaviour depending on the social context. However, arguably, the neurophysiological mechanisms underlying contextual modulation of GF remain somewhat unexplored. In this study, we tested the proposition about whether the contextual modulation of infant GF is mediated by the infant's heart rate (HR), which indicates the infant's physiological arousal. Forty-one 6- to 9-month-old infants participated in this study, and infants observed either a reliable face, which looked towards the location of an object, or an unreliable face, which looked away from the location of an object. Thereafter, the infants watched a video of the same model making eye contact or not making any ostensive signals, before shifting their gaze towards one of the two objects. We revealed that reliability and eye contact acted independently to increase HR, which then fully mediates the effects of these social cues on the frequency of GF. Results suggest that each social cue independently enhances physiological arousal, which then accumulatively predicts the likelihood of infant GF behaviour.

Development of a classifier to screen for severe sleep disorders in children.

This study aimed to develop an automatic classifier for the identification of severe sleep disorders that require immediate intervention in children. Our study assessed 7,008 children (age: 0-83 months) in Japan, whose parents and nursery teachers recorded their 14-day sleep patterns. Sleep quality was assessed by pediatricians and scored as 1 (no severe sleep disorder) or 0 (severe sleep disorder). Discriminant analysis was performed for each age group using sleep quality (0 or 1) as the dependent variable and variables in the 14-day sleep log as independent variables. A stepwise method was used to select the independent variables to build the best model. The accuracy of the discriminant analysis for the age groups ranged from 71.3 to 97.3%. In summary, we developed an automatic classifier with sufficient application value to screen for severe sleep disorders in children. In the future, this classifier can be used to rapidly determine the presence or absence of severe sleep disorders in children based on their 14-day sleep logs, thus allowing immediate intervention.

Pupil dilation predicts modulation of direct gaze on action value calculations.

Perceiving direct gaze facilitates social cognition and behaviour. We hypothesized that direct gaze modulates decision-making, particularly calculations of action values. To test our hypothesis, we used the reinforcement learning paradigm in situations with or without direct gaze. Forty adults were recruited and participated in pupil size measurements and a two-armed bandit task. The task was conducted with 70% and 30% reward probabilities for each option. During the task, a female showing the Direct Gaze (DG) or Closed Eyes (CE) condition was presented from the start of each trial. The results showed that behavioural bias to choices with 70% reward probability increased more in the DG condition than in the CE condition and the expected reward value. This bias to choices with 70% reward in the DG condition was predicted by pupil dilation to DG. These results suggest that participants over-evaluated the expected reward value in the DG condition, and this DG effect may be related to subjective expectations of rewarding events indexed by pupil dilations. It is considered that perceiving direct gaze is a driver of reward expectations that modulate action value calculations and then cognitive processing and behaviours are facilitated.

Baby's Online Live Database: An Open Platform for Developmental Science.

Efficient data collection in developmental studies is facing challenges due to the decreased birth rates in many regions, reproducibility problems in psychology research, and the COVID-19 pandemic. Here, we propose a novel platform for online developmental science research, the Baby's Online Live Database (BOLD), which extends the scope of the accessible participant pool, simplifies its management, and enables participant recruitment for longitudinal studies. Through BOLD, researchers can conduct online recruitment of participants preregistered to BOLD simply by specifying their attributes, such as gender and age, and direct the participants to dedicated webpages for each study. Moreover, BOLD handles participant recruitment and reward payment, thereby freeing researchers from the labor of participant management. BOLD also allows researchers the opportunity to access data that were collected from participants in previous research studies. This enables researchers to carry out longitudinal analyses at a relatively low cost. To make BOLD widely accessible, a consortium was formed within the Japan Society of Baby Science, where members from diverse research groups discussed the blueprint of this system. Once in full-scaled operation, BOLD is expected to serve as a platform for various types of online studies and facilitate international collaboration among developmental scientists in the near future.

The role of executive functions in older adults' affective theory of mind.

PURPOSE: Executive function (EF) has three subsystems: inhibition, updating, and shifting. Of these three, only inhibition is considered to be involved in affective theory of mind (ToM). This study investigated whether inhibition remains the sole driver for affective ToM in the three EF subsystems in older adults as well as in young people without functional reorganization via aging within EF. MATERIALS AND METHODS: Through hierarchical multiple regression analysis, we examined how these three subsystems affect older participants' performance in the Reading the Mind in the Eyes Test (RMET), a measure of affective ToM, after determining the effect of domain-specific cognitive (nonverbal and verbal) abilities. RESULTS: We found that only inhibition influenced the participants' performance in the RMET, with effects from nonverbal (fluid) ability but not from verbal ability. CONCLUSIONS: Results showed that inhibition continues to be essential for affective ToM after aging decline, and functional reorganization via aging is less likely to occur within EF.

Individual recognition of monkey (Macaca fuscata) and human (Homo sapiens) images in primatologists.

How experience affects the flexibility of facial identity recognition in adulthood is not fully understood. Primatologists are an interesting type of participants investigating facial identity recognition ability and flexibility because they can recognize individual primates based on their appearance, including body and facial features, through intense training during adulthood. Consequently, this study investigates the influence of primatological experience on individual recognition ability using eye-tracking techniques and sequential 2-alternative forced-choice matching tasks with images of humans (Homo sapiens) and Japanese macaques (Macaca fuscata). Results indicated that primatologists recognized faces of Japanese macaques more accurately than did control participants, while both primatologists and control participants recognized humans' faces with high accuracy. Primatologists demonstrated better recognition of monkey images when the whole body was presented than when only the face was presented, whereas control participants did not. Compared to the control participants, primatologists looked at areas other than the monkeys' faces for a longer time when whole-body images were presented. Furthermore, primatological experience (including study period and a total number of recognizable subjects in their studies) was related to the extent to which individual recognition of monkeys depended on nonface information. Altogether, our findings indicate that primatological experience improves the viewer's ability to recognize monkeys' faces. In addition, if available, primatologists with more experience studying monkeys use information from other parts of the body to recognize individual monkeys. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Great apes' understanding of biomechanics: eye-tracking experiments using three-dimensional computer-generated animations.

Visual processing of the body movements of other animals is important for adaptive animal behaviors. It is widely known that animals can distinguish articulated animal movements even when they are just represented by points of light such that only information about biological motion is retained. However, the extent to which nonhuman great apes comprehend the underlying structural and physiological constraints affecting each moving body part, i.e., biomechanics, is still unclear. To address this, we examined the understanding of biomechanics in bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), following a previous study on humans (Homo sapiens). Apes underwent eye tracking while viewing three-dimensional computer-generated (CG) animations of biomechanically possible or impossible elbow movements performed by a human, robot, or nonhuman ape. Overall, apes did not differentiate their gaze between possible and impossible movements of elbows. However, some apes looked at elbows for longer when viewing impossible vs. possible robot movements, which indicates that they may have had knowledge of biomechanics and that this knowledge could be extended to a novel agent. These mixed results make it difficult to draw a firm conclusion regarding the extent to which apes understand biomechanics. We discuss some methodological features that may be responsible for the results, as well as implications for future nonhuman animal studies involving the presentation of CG animations or measurement of gaze behaviors.

Source memory and social exchange in young children.

Reciprocal interactions require memories of social exchanges; however, little is known about how we remember social partner actions, especially during childhood when we start forming peer-to-peer relationships. This study examined if the expectation-violation effect, which has been observed in adults' source memory, exists among 5-6-year-old children. Forty participants played a coin collection game where they either received or lost coins after being shown an individual with a smiling or angry expression. This set-up generated congruent (smiling-giver and angry-taker) versus incongruent (smiling-taker and angry-giver) conditions. In the subsequent tasks, the children were asked to recall which actions accompanied each individual. The children considered the person with incongruent conditions as being stranger than the person with congruent conditions, suggesting that the former violated the children's emotion-based expectations. However, no heightened source memory was found for the incongruent condition. Instead, children seem to better recognise the action of angry individuals than smiling individuals, suggesting that angry facial expressions are more salient for children's source memory in a social exchange.

Affective priming enhances gaze cueing effect.

Other's gaze direction triggers a reflexive shift of attention known as the gaze cueing effect. Fearful facial expressions are further reported to enhance the gaze cueing effect, but it remains unclear whether this facilitative effect is specific to gaze cues or the result of more general increase in attentional resources resulting from affective arousal. We examined the effects of affective priming on the cueing effects of gaze and arrow stimuli in the Posner cueing task. Participants were primed with two types of briefly presented affective stimuli (neutral, threatening), and the target location was cued either by an arrow or a gaze cue in a neutral face. Gaze cues were preceded by the same face with its eyes closed or directed to the viewer. Study 1 (n = 26) assessed the cueing effect using manual key press, and Study 2 (n = 30) employed gaze-contingent eye tracking techniques to assess the cueing effect using time to first fixate the cued target location. Both studies found that threatening priming significantly enhanced the cueing effects of eye gaze but not arrow stimuli. The results therefore suggest that affective priming does not facilitate general attentional orienting, but the facilitation is more specific to social cues such as eye gaze. (PsycInfo Database Record (c) 2021 APA, all rights reserved).