RESUMO
OBJECTIVE: to perform a complex ophthalmological and general examination of patients with retinal vein occlusion (RVO) and to derive classification criteria for retinal ischemia. MATERIALS AND METHODS: A total of 44 patients with RVO and macular edema and 20 controls were enrolled. All patients underwent a thorough ophthalmological and general examination and clinical laboratory testing. RESULTS: Cardinal risk factors of RVO development were derived from among somatic illnesses and laboratory results. Regional hemodynamics assessment helped identify the most significant systolic and diastolic blood flow disturbances in the central retinal vein and central retinal artery circulation systems. Profound changes in electrophysiological parameters were found. Statistical analysis of the collected data allowed to identify 3 stages of retinal ischemia. CONCLUSION: The established risk factors of RVO development, regional blood flow impairment and original classification criteria for retinal ischemia make it possible to predict the course of the disease and treatment effect.
Assuntos
Isquemia , Retina , Oclusão da Veia Retiniana , Vasos Retinianos/diagnóstico por imagem , Idoso , Dislipidemias/epidemiologia , Feminino , Hemodinâmica , Humanos , Hipertensão/epidemiologia , Isquemia/classificação , Isquemia/diagnóstico , Isquemia/epidemiologia , Edema Macular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Gravidade do Paciente , Prognóstico , Análise de Regressão , Retina/patologia , Retina/fisiopatologia , Oclusão da Veia Retiniana/complicações , Oclusão da Veia Retiniana/diagnóstico , Oclusão da Veia Retiniana/fisiopatologia , Medição de Risco , Fatores de Risco , Ultrassonografia Doppler em Cores/métodosRESUMO
Cytokine and growth factors levels were estimated in anterior chamber humor of patients with different diseases manifesting with vascular and neovascular retinal changes and various pathologic process activity. 40 patients with macula edema, retinal and choroid neovascularization were examined. Process activity was determined based on data obtained using high-resolution optical coherence tomography and fluorescent angiography. Quantitative concentration of interleukine 6, 8, vascular endothelium growth factor and monocyte chemoattractive protein-1 in anterior chamber aqueous humor was measured using enzyme immunoassay. Increased level of cytokines studied was found in all forms of the diseases.
